The DOI matches its Crossref record.
Resistance to Antiviral Drugs of Herpes Simplex Virus Isolated from a Patient Treated with Acyclovir
Abstract
SEVERAL drugs that inhibit the replication of herpesvirus in vitro are now being evaluated for the prevention or treatment of infections with herpes simplex virus and varicella zoster virus.1 2 3 Two of these drugs, acyclovir or 9-[(2-hydroxyethoxy)-methyl]guanine and the thymidine analogue E-5-(2-bromovinyl)-2′deoxyuridine (BVDU), are the most efficient inhibitors of herpes simplex virus Type 1 plaque formation yet described.4 5 6 To inhibit the growth of herpes simplex virus and presumably that of varicella zoster virus, acyclovir and BVDU must first be phosphorylated to the respective monophosphates by virus-specified thymidine kinase and must then be converted by cellular enzymes to the respective triphosphates, . . .
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Cited by
Vidarabine versus Acyclovir Therapy in Herpes Simplex Encephalitis
Whitley, R. J., Alford, C. A., Hirsch, M. S., Schooley, R. T., Luby, J. P., Aoki, F. Y., Hanley, D., Nahmias, A. J., Soong, S.-J., & The NIAID Collaborative Antiviral Study Group* (1986) · New England Journal of Medicine · doi:10.1056/nejm198601163140303 · Cited by 896
Herpes simplex virus resistance to antiviral drugs
Morfin, F., & Thouvenot, D. (2003) · Journal of Clinical Virology · doi:10.1016/s1386-6532(02)00263-9 · Cited by 438
Metadata
- Authors
- Crumpacker, C. S., Schnipper, L. E., Marlowe, S. I., Kowalsky, P. N., Hershey, B. J., & Levin, M. J.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1982-02-11
- Volume
- 306
- Issue
- 6
- Pages
- 343-346
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2052460032
- Cited by
- 345
- References
- 0
- FWCI
- 41.26
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Resistance to Antiviral Drugs of Herpes Simplex Virus Isolated from a Patient Treated with Acyclovir. https://app.cochat.ai/papers/10.1056/nejm198202113060606
- The paper
- Crumpacker, C. S., Schnipper, L. E., Marlowe, S. I., Kowalsky, P. N., Hershey, B. J., & Levin, M. J. (1982). Resistance to Antiviral Drugs of Herpes Simplex Virus Isolated from a Patient Treated with Acyclovir. New England Journal of Medicine. https://doi.org/10.1056/nejm198202113060606
Data sources
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
