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Deficient Red-Cell Spectrin in Severe, Recessively Inherited Spherocytosis
Abstract
RED-CELL-membrane architecture has been extensively studied in recent years.1 , 2 When the cells are hypotonically lysed and washed free of hemoglobin, the resulting membrane ghosts consist of the lipid bilayer and associated proteins. When ghosts are extracted with non-ionic detergents, lipid and integral membrane proteins are removed, leaving a cytoskeleton3 that is thought to be responsible for the shape, strength, and reversible deformability of the cell. The cytoskeleton consists of an assembly of polypeptides: spectrin (the largest and most abundant protein of the membrane), band 4.1, and actin. The cytoskeleton is attached to the membrane by the association of spectrin with . . .
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Cited by
Spectrin and Ankyrin-Based Pathways: Metazoan Inventions for Integrating Cells Into Tissues
Bennett, V., & Baines, A. J. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.3.1353 · Cited by 930
Self-citationThe spectrin-actin junction of erythrocyte membrane skeletons
Bennett, V. (1989) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/0304-4157(89)90006-3 · Cited by 295
Self-citationSprenkeler, E. G. G., Webbers, S. D. S., & Kuijpers, T. W. (2021) · Journal of Innate Immunity · doi:10.1159/000509717 · Cited by 54
Metadata
- Authors
- Agre, P., Orringer, E. P., & Bennett, V.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1982-05-13
- Volume
- 306
- Issue
- 19
- Pages
- 1155-1161
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W1986783431
- Cited by
- 171
- References
- 0
- FWCI
- 12.70
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Deficient Red-Cell Spectrin in Severe, Recessively Inherited Spherocytosis. https://app.cochat.ai/papers/10.1056/nejm198205133061906
- The paper
- Agre, P., Orringer, E. P., & Bennett, V. (1982). Deficient Red-Cell Spectrin in Severe, Recessively Inherited Spherocytosis. New England Journal of Medicine. https://doi.org/10.1056/nejm198205133061906
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
