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D-Lactic Acidosis Due to Abnormal Gut Flora: Diagnosis and Treatment of Two Cases
Abstract
METABOLIC acidosis caused by D-lactic acid, the optical isomer of L-lactic acid, was recently described by Oh et al. in a patient with a short-bowel syndrome.1 We encountered a similar condition in two patients with prior gut surgery. One patient had undergone an extensive small-bowel resection after mesenteric infarction, and the other had had a jejunoileal bypass for obesity. These patients presented with repeated episodes of stupor or coma, metabolic acidosis with an increased anion gap, normal plasma levels of L-lactate, and elevated plasma levels of D-lactate. Treatment with oral vancomycin resulted in normalization of the neurologic and metabolic status. . . .
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Cited by
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Bacteria, Colonic Fermentation, and Gastrointestinal Health
Macfarlane, G. T., & Macfarlane, S. (2012) · Journal of AOAC INTERNATIONAL · doi:10.5740/jaoacint.sge_macfarlane · Cited by 970
Short-Term Benefit From Oral Vancomycin Treatment of Regressive-Onset Autism
Sandler, R. H., Finegold, S. M., Bolte, E. R., Buchanan, C. P., Maxwell, A. P., Väisänen, M.-L., Nelson, M. N., & Wexler, H. M. (2000) · Journal of Child Neurology · doi:10.1177/088307380001500701 · Cited by 614
Self-citationSafety assessment of polylactide (PLA) for use as a food-contact polymer
Conn, R. E., Kolstad, J. J., Borzelleca, J. F., Dixler, D. S., Filer, L. J., Ladu, B. N., & Pariza, M. W. (1995) · Food and Chemical Toxicology · doi:10.1016/0278-6915(94)00145-e · Cited by 344
Uribarri, J., Oh, M. S., & Carroll, H. J. (1998) · Medicine · doi:10.1097/00005792-199803000-00001 · Cited by 326
Metadata
- Authors
- Stolberg, L., Rolfe, R., Gitlin, N., Merritt, J., Mann, L., Linder, J., & Finegold, S.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1982-06-03
- Volume
- 306
- Issue
- 22
- Pages
- 1344-1348
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2025895460
- Cited by
- 161
- References
- 0
- FWCI
- 10.48
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: D-Lactic Acidosis Due to Abnormal Gut Flora: Diagnosis and Treatment of Two Cases. https://app.cochat.ai/papers/10.1056/nejm198206033062207
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- Stolberg, L., Rolfe, R., Gitlin, N., Merritt, J., Mann, L., Linder, J., & Finegold, S. (1982). D-Lactic Acidosis Due to Abnormal Gut Flora: Diagnosis and Treatment of Two Cases. New England Journal of Medicine. https://doi.org/10.1056/nejm198206033062207
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
