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Cited by 1,454Cancer, Hypoxia, and MetabolismMetabolism, Diabetes, and CancerMicrobial metabolism and enzyme function

Lactate metabolism in human health and disease

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Li, Xiaolu, Yang, Yanyan, Zhang, Bei, Lin, Xiaotong, Fu, Xiuxiu, An, Yi, Zou, Yulin, Wang, Jian-Xun +2 more·2022·Signal Transduction and Targeted Therapy
DOI 10.1038/s41392-022-01151-3PMC PMC9434547
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Abstract

The current understanding of lactate extends from its origins as a byproduct of glycolysis to its role in tumor metabolism, as identified by studies on the Warburg effect. The lactate shuttle hypothesis suggests that lactate plays an important role as a bridging signaling molecule that coordinates signaling among different cells, organs and tissues. Lactylation is a posttranslational modification initially reported by Professor Yingming Zhao’s research group in 2019. Subsequent studies confirmed that lactylation is a vital component of lactate function and is involved in tumor proliferation, neural excitation, inflammation and other biological processes. An indispensable substance for various physiological cellular functions, lactate plays a regulatory role in different aspects of energy metabolism and signal transduction. Therefore, a comprehensive review and summary of lactate is presented to clarify the role of lactate in disease and to provide a reference and direction for future research. This review offers a systematic overview of lactate homeostasis and its roles in physiological and pathological processes, as well as a comprehensive overview of the effects of lactylation in various diseases, particularly inflammation and cancer.

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Cited by

Sorted by citations

Authors
Li, X., Yang, Y., Zhang, B., Lin, X., Fu, X., An, Y., Zou, Y., Wang, J.-X., Wang, Z., & Yu, T.
Affiliations
  • Affiliated Hospital of Qingdao University (CN)
  • Qingdao University (CN)
  • Qingdao Municipal Hospital (CN)
Corresponding author
  • Wang, Zhibin
  • Yu, Tao
ORCID
Venue
Signal Transduction and Targeted Therapy
Publisher
Springer Science and Business Media LLC
Published
2022-09-01
Volume
7
Issue
1
Pages
305-305
ISSN
2059-3635 (ISSN-L)
DOI
10.1038/s41392-022-01151-3
PMC
PMC9434547
OpenAlex
W4294031309
Cited by
1,454
References
18
Citations by year
2026: 405 · 2025: 538 · 2024: 354 · 2023: 147 · 2022: 9
FWCI
31.71
Type
journal article
Language
en
Update notices
correction (2022-10-31)
Open access
Licence
Locations
  • Signal Transduction and Targeted Therapy (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Natural Science Foundation of China (81870331)
  • Qingdao Municipal Science and Technology Bureau (21-1-4-rkjk-12-nsh)
  • Natural Science Foundation of Shandong Province (ZR2020MH045)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial metabolism and enzyme function
Keywords
lactate metabolism, Warburg effect, cancer metabolism, lactylation, post-translational modification, energy metabolism, signal transduction, inflammation, cancer
MeSH terms
Glycolysis, Homeostasis, Humans, Inflammation, Neoplasms, Lactic Acid

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