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Multiple Sclerosis
Abstract
(First of Two Parts)The lesions of multiple sclerosis were probably described as early as 1838,1 but it was Charcot in 18682 who recognized the characteristic clinical and pathologic features of the disease. Since that time, the disorder has been studied extensively. Numerous distinguished, even renowned physicians and scientists have investigated various aspects of multiple sclerosis. Although much has been learned and many theories have emerged, the cause and pathogenesis of this disease remains unknown. No preventive measures or definitive therapies exist. The purpose of this article is to review the classic clinical and pathologic aspects of the disease and . . .
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Citations
Cited by
Immunology of multiple sclerosis
Sospedra, M., & Martin, R. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115707 · Cited by 2,149
T-cell recognition of an immuno-dominant myelin basic protein epitope in multiple sclerosis
Ota, K., Matsui, M., Milford, E. L., Mackin, G. A., Weiner, H. L., & Hafler, D. A. (1990) · Nature · doi:10.1038/346183a0 · Cited by 912
Cellular immune reactivity within the CNS
Wekerle, H., Linington, C., Lassmann, H., & Meyermann, R. (1986) · Trends in Neurosciences · doi:10.1016/0166-2236(86)90077-9 · Cited by 768
Fukaura, H., Kent, S. C., Pietrusewicz, M. J., Khoury, S. J., Weiner, H. L., & Hafler, D. A. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118779 · Cited by 473
Shared Human T Cell Receptor V β Usage to Immunodominant Regions of Myelin Basic Protein
Wucherpfennig, K. W., Ota, K., Endo, N., Seidman, J. G., Rosenzweig, A., Weiner, H. L., & Hafler, D. A. (1990) · Science · doi:10.1126/science.1693015 · Cited by 386
Metadata
- Authors
- McFarlin, D. E., & McFarland, H. F.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1982-11-04
- Volume
- 307
- Issue
- 19
- Pages
- 1183-1188
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2413496808
- Cited by
- 416
- References
- 0
- FWCI
- 16.02
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Multiple Sclerosis. https://app.cochat.ai/papers/10.1056/nejm198211043071905
- The paper
- McFarlin, D. E., & McFarland, H. F. (1982). Multiple Sclerosis. New England Journal of Medicine. https://doi.org/10.1056/nejm198211043071905
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
