The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Shared Human T Cell Receptor V β Usage to Immunodominant Regions of Myelin Basic Protein
Abstract
Multiple sclerosis (MS) may be an autoimmune disease mediated by T cells specific for a myelin protein. Investigations have demonstrated myelin basic protein (MBP)-reactive T cells that were activated in vivo in MS patients, suggesting that MBP may be a target antigen in MS. The variable (V) region of the T cell receptor (TCR) β chain was examined among 83 T cell lines from both MS patients and healthy subjects that were reactive with the immunodominant region of human MBP (residues 84 to 102) or with a second immunodominant region of MBP (143 to 168). V β 17 and to a lesser extent V β 12 were frequently used in recognition of MBP(84-102) among different individuals. In contrast, V β 17 was very infrequent among lines reactive with MBP (143-168). These data demonstrate shared TCR V β gene usage for the recognition of immunodominant regions of the human autoantigen MBP. Such TCR structures may be used as targets for specific immunotherapy in MS.
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HLA and Disease 1982 ‐ A Survey
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Cited by
Immunology of multiple sclerosis
Sospedra, M., & Martin, R. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115707 · Cited by 2,149
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Autoimmunity, microbial immunity and the immunological homunculus
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Immunological aspects of experimental allergic encephalomyelitis and multiple sclerosis
Martin, R., McFarland, H. F., & Boggs, J. M. (1995) · Critical Reviews in Clinical Laboratory Sciences · doi:10.3109/10408369509084683 · Cited by 376
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Metadata
- Authors
- Wucherpfennig, K. W., Ota, K., Endo, N., Seidman, J. G., Rosenzweig, A., Weiner, H. L., & Hafler, D. A.
- Venue
- Science
- Published
- 1990-05-25
- Volume
- 248
- Issue
- 4958
- Pages
- 1016-1019
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2124626123
- Cited by
- 386
- References
- 25
- FWCI
- 53.80
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Shared Human T Cell Receptor V β Usage to Immunodominant Regions of Myelin Basic Protein. https://app.cochat.ai/papers/10.1126/science.1693015
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- Wucherpfennig, K. W., Ota, K., Endo, N., Seidman, J. G., Rosenzweig, A., Weiner, H. L., & Hafler, D. A. (1990). Shared Human T Cell Receptor V β Usage to Immunodominant Regions of Myelin Basic Protein. Science. https://doi.org/10.1126/science.1693015
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
