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The Gasping Syndrome and Benzyl Alcohol Poisoning
Abstract
Benzyl alcohol is commonly used as an antibacterial agent in a variety of formulations, including bacteriostatic sodium chloride and bacteriostatic water, that are intended for intravenous administration. Although benzyl alcohol toxicity has been recognized, the concentration that is necessary for antibacterial action appears to be much lower than the concentration that would be dangerous to adults.1 , 2 Little, if anything, is known about the possible toxic effects of benzyl alcohol in neonates.Ten premature infants in our neonatal intensivecare unit developed similar clinical syndromes characterized by the deterioration of multiple organ systems and eventual death, which we believe were the result . . .
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Citations
Cited by
Final Report on the Safety Assessment of Benzyl Alcohol, Benzoic Acid, and Sodium Benzoate
(2001) · International Journal of Toxicology · doi:10.1080/10915810152630729 · Cited by 367
Committee on Drugs (1998) · PEDIATRICS · doi:10.1542/peds.101.6.1079 · Cited by 234
Drug-Induced Liver Injury in Children: Clinical Observations, Animal Models, and Regulatory Status
Shi, Q., Yang, X., Greenhaw, J. J., Salminen, A. T., Russotti, G. M., & Salminen, W. F. (2017) · International Journal of Toxicology · doi:10.1177/1091581817721675 · Cited by 37
Metadata
- Authors
- Gershanik, J., Boecler, B., Ensley, H., McCloskey, S., & George, W.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1982-11-25
- Volume
- 307
- Issue
- 22
- Pages
- 1384-1388
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2067658642
- Cited by
- 263
- References
- 0
- FWCI
- 5.44
- Type
- journal article
- Language
- en
- Open access
- closed
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How to cite
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- CoChat. (2026). Citation check: The Gasping Syndrome and Benzyl Alcohol Poisoning. https://app.cochat.ai/papers/10.1056/nejm198211253072206
- The paper
- Gershanik, J., Boecler, B., Ensley, H., McCloskey, S., & George, W. (1982). The Gasping Syndrome and Benzyl Alcohol Poisoning. New England Journal of Medicine. https://doi.org/10.1056/nejm198211253072206
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
