The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Potential Role of Increased Sympathetic Activity in Impaired Sodium and Water Excretion in Cirrhosis
Abstract
In a study of 26 patients with cirrhosis, plasma norepinephrine concentrations were significantly higher in 19 patients who abnormally excreted an acute water load than in seven who excreted the load normally (8324 +/- 116 vs. 306 +/- 33 pg per milliliter; P less than 0.001). There was also a significant positive correlation between plasma levels of norepinephrine and arginine vasopressin after the water load, as well as a negative correlation between plasma norepinephrine and the percentage of the load excreted. A positive correlation between plasma norepinephrine and plasma renin activity, as well as between norepinephrine and aldosterone, was observed. In addition, there was a negative correlation between plasma norepinephrine and urinary sodium excretion. These findings indicate that increased sympathetic activity, as assessed by plasma levels of norepinephrine, correlates closely with sodium and water retention in cirrhotic patients and thus may be of pathogenetic importance.
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Citations
Cites
Enzymatic O-methylation of epinephrine and other catechols
Axelrod, J., & Tomchick, R. (1958) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)64731-3 · Cited by 1,283
Cited by
Lebrec, D., Giuily, N., Hadengue, A., Vilgrain, V., Moreau, R., Poynard, T., Gadano, A., Lassen, C., Benhamou, J.-P., & Erlinger, S. (1996) · Journal of Hepatology · doi:10.1016/s0168-8278(96)80065-1 · Cited by 447
Schrier, R. W. (1988) · New England Journal of Medicine · doi:10.1056/nejm198810203191606 · Cited by 348
Self-citationPathophysiology of Portal Hypertension
Iwakiri, Y. (2014) · Clinics in Liver Disease · doi:10.1016/j.cld.2013.12.001 · Cited by 337
Nature and quantity of fuels consumed in patients with alcoholic cirrhosis.
Owen, O. E., Trapp, V. E., Reichard, G. A., Mozzoli, M. A., Moctezuma, J., Paul, P., Skutches, C. L., & Boden, G. (1983) · Journal of Clinical Investigation · doi:10.1172/jci111142 · Cited by 332
Hepatorenal Syndrome: Pathophysiology and Management
Wadei, H. M., Mai, M. L., Ahsan, N., & Gonwa, T. A. (2006) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.01340406 · Cited by 275
Metadata
- Authors
- Bichet, D. G., Putten, V. J. V., & Schrier, R. W.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1982-12-16
- Volume
- 307
- Issue
- 25
- Pages
- 1552-1557
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2036487592
- Cited by
- 355
- References
- 1
- FWCI
- 19.95
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Potential Role of Increased Sympathetic Activity in Impaired Sodium and Water Excretion in Cirrhosis. https://app.cochat.ai/papers/10.1056/nejm198212163072504
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- Bichet, D. G., Putten, V. J. V., & Schrier, R. W. (1982). Potential Role of Increased Sympathetic Activity in Impaired Sodium and Water Excretion in Cirrhosis. New England Journal of Medicine. https://doi.org/10.1056/nejm198212163072504
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
