The DOI matches its Crossref record; 132 of the 132 references it cites were found in a registry or an index.
Pathophysiology of Portal Hypertension
Open accessAbstract
Portal hypertension is a major complication of liver disease, which results from a variety of pathological conditions that increase the resistance to the portal blood flow into the liver. The primary cause of portal hypertension in cirrhosis is an increase in intrahepatic vascular resistance due to massive structural changes associated with fibrosis and increased vascular tone in the hepatic microcirculation. As portal hypertension develops, the formation of collateral vessels and arterial vasodilation progress, which results in increased blood flow to the portal circulation. Eventually the hyperdynamic circulatory syndrome develops, leading to esophageal varices or ascites. This review article will summarize the factors that increase 1) intrahepatic vascular resistance and 2) the blood flow in the splanchnic and systemic circulations in liver cirrhosis. Finally, the future directions of basic/clinical research in portal hypertension will be discussed.
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Cited by
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Cellular Mechanisms of Liver Fibrosis
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Metadata
- Authors
- Iwakiri, Y.
- Venue
- Clinics in Liver Disease
- Publisher
- Elsevier BV
- Published
- 2014-05
- Volume
- 18
- Issue
- 2
- Pages
- 281-291
- ISSN
- 1089-3261 (ISSN-L)
- OpenAlex
- W2048951077
- Cited by
- 337
- References
- 132
- FWCI
- 6.40
- Type
- journal article
- Language
- en
- Open access
- green
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