The DOI matches its Crossref record.
Oxidation Phenotype — A Major Determinant of Metoprolol Metabolism and Response
Abstract
GENETIC polymorphism in the oxidative metabolism of debrisoquine1 is largely responsible for individual differences in its plasma concentration and antihypertensive effect.2 Poor hydroxylators have urinary debrisoquine:4-hydroxydebrisoquine ratios that are higher than 20, whereas extensive hydroxylators have ratios that are less than 12.5.3 , 4 The prevalence of the poor hydroxylator phenotype is about 9 per cent in the United Kingdom3 but it varies widely among ethnic groups, from 1 per cent in Arabs to 30 per cent in Hong Kong Chinese.5 The prevalence of this phenotype in the United States has not been reported, but among whites in Canada it appears to . . .
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Citations
Cited by
Pharmacogenetics, Drug-Metabolizing Enzymes, and Clinical Practice
Gardiner, S. J., & Begg, E. J. (2006) · Pharmacological Reviews · doi:10.1124/pr.58.3.6 · Cited by 406
Cardiovascular pharmacogenomics and individualized drug therapy
Pereira, N. L., & Weinshilboum, R. M. (2009) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2009.154 · Cited by 72
Metadata
- Authors
- Lennard, M. S., Silas, J. H., Freestone, S., Ramsay, L. E., Tucker, G. T., & Woods, H. F.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1982-12-16
- Volume
- 307
- Issue
- 25
- Pages
- 1558-1560
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2092510009
- Cited by
- 279
- References
- 0
- FWCI
- 13.84
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Oxidation Phenotype — A Major Determinant of Metoprolol Metabolism and Response. https://app.cochat.ai/papers/10.1056/nejm198212163072505
- The paper
- Lennard, M. S., Silas, J. H., Freestone, S., Ramsay, L. E., Tucker, G. T., & Woods, H. F. (1982). Oxidation Phenotype — A Major Determinant of Metoprolol Metabolism and Response. New England Journal of Medicine. https://doi.org/10.1056/nejm198212163072505
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
