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The Pharmacology and Clinical Use of Methotrexate
Abstract
METHOTREXATE, the most widely used antimetabolite in cancer chemotherapy, has an essential role in the treatment of such diverse diseases as acute lymphocytic leukemia, non-Hodgkin's lymphoma, osteosarcoma, choriocarcinoma, head and neck cancer, and breast cancer.1 It has also become an important therapeutic alternative in the treatment of severe psoriasis2 and in the suppression of graft-versus-host disease after bone-marrow transplantation,3 as well as in the experimental treatment of various rheumatic diseases after primary therapy has failed.4 Through pharmacologic research we have gained an understanding of the basic steps in the action of methotrexate, including its transport across cell membranes, its intracellular . . .
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Cited by
Effect of a Glutamine‐Supplemented Enteral Diet on Methotrexate‐Induced Enterocolitis
Fox, A. D., Kripke, S. A., De Paula, J., Berman, J. M., Settle, R. G., & Rombeau, J. L. (1988) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607188012004325 · Cited by 317
Drug-induced kidney stones and crystalline nephropathy: pathophysiology, prevention and treatment
Daudon, M., Frochot, V., Bazin, D., & Jungers, P. (2018) · Drugs · doi:10.1007/s40265-017-0853-7 · Cited by 191
Effect of aged garlic extract against methotrexate-induced damage to the small intestine in rats
Yüncü, M., Eralp, A., & Celõk, A. (2006) · Phytotherapy Research · doi:10.1002/ptr.1896 · Cited by 28
Metadata
- Authors
- Jolivet, J., Cowan, K. H., Curt, G. A., Clendeninn, N. J., & Chabner, B. A.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1983-11-03
- Volume
- 309
- Issue
- 18
- Pages
- 1094-1104
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W1971035689
- Cited by
- 786
- References
- 0
- FWCI
- 9.51
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: The Pharmacology and Clinical Use of Methotrexate. https://app.cochat.ai/papers/10.1056/nejm198311033091805
- The paper
- Jolivet, J., Cowan, K. H., Curt, G. A., Clendeninn, N. J., & Chabner, B. A. (1983). The Pharmacology and Clinical Use of Methotrexate. New England Journal of Medicine. https://doi.org/10.1056/nejm198311033091805
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
