The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Follow-up of Solitary Autonomous Thyroid Nodules Treated with 131I
Abstract
We studied the long-term effects of 131I therapy for solitary autonomous thyroid nodules on the size of the nodule and on thyroid function. Twenty-three patients with autonomous thyroid adenomas that had been treated with 131I from 4 to 16.5 years earlier (mean, 8.5) were examined, and their thyroid function was tested. In 12 patients (54 per cent), the nodules were still palpable, and in 2 they had increased in size. Eight patients (36 per cent) had become hypothyroid. The incidence of hypothyroidism was not related to nodule size or the level of thyroid function before therapy with 131I or to the total dose of 131I that had been given. We conclude that 131I therapy for autonomous thyroid adenoma often causes hypothyroidism and in many cases does not eradicate the offending nodule.
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“The prevalence of hypothyroidism after RAI is progressive and hastened by the presence of antithyroid antibodies or a nonsuppressed TSH at the time of treatment (257,259,260).”
From 2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis (2016) · cites this paper as [260]
In the citing paper
“The nodule is rarely eradicated in patients with TA undergoing RAI therapy, which can lead to the need for continued surveillance (225,257,260).”
From 2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis (2016) · cites this paper as [260]
Citations
Cites
Solitary autonomously functioning thyroid lesions
Hamburger, J. I. (1975) · The American Journal of Medicine · doi:10.1016/0002-9343(75)90630-0 · Cited by 113
THE STUDY AND TREATMENT OF 119 CASES OF CARCINOMA OF THE THYROID WITH RADIOACTIVE IODINE*†
DOBYNS, B. M., & Maloof, F. (1951) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-11-11-1323 · Cited by 92
Miller, J. M., & Hamburger, J. I. (1965) · Radiology · doi:10.1148/84.1.66 · Cited by 91
Horst, W., Rösler, H., Schneider, C. G., & Labhart, A. (1967) · PubMed · Cited by 79
The autonomous nodule of the thyroid: correlation of patient age, nodule size and functional status
Blum, M., SHENKMAN, L., & Hollander, C. S. (1975) · The American Journal of the Medical Sciences · doi:10.1097/00000441-197501000-00006 · Cited by 69
Radiation Dose in the Selection of 131I or Surgical Treatment for Toxic Thyroid Adenoma
Gorman, C. A., & ROBERTSON, J. S. (1978) · Annals of Internal Medicine · doi:10.7326/0003-4819-89-1-85 · Cited by 65
ON THE HYPERFUNCTIONING SOLITARY THYROID NODULE
Molnar, G. D., Wilber, R. D., Lee, R. E., Woolner, L. B., & KEATING, F. R. (1965) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(25)14212-2 · Cited by 58
THE CLINICAL AND PATHOLOGIC RELATIONSHIPS OF HYPERPLASTIC AND NONHYPERPLASTIC GOITER
Plummer, H. S. (1913) · JAMA · doi:10.1001/jama.1913.04350090018006 · Cited by 55
The Natural History of the Autonomous Hyperfunctioning Thyroid Nodule
Silverstein, G. E., BURKE, G., & COGAN, R. (1967) · Annals of Internal Medicine · doi:10.7326/0003-4819-67-3-539 · Cited by 52
Radioiodine in Diagnosis and Therapy of Hyperthyroidism
Skillern, P. G. (1962) · Archives of Internal Medicine · doi:10.1001/archinte.1962.03620240070011 · Cited by 43
Research works printed but not linked: 4
- McCormack, 1967, J Nucl Med, 8, 701
- Molnar, 1975, Mayo Clin Proc, 40, 665
- Horst, 1967, J Nucl Med, 8, 515
- Fontana, 1980, J Nucl Med Allied Sci, 24, 85
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Ross, D. S., Burch, H. B., Cooper, D. S., Greenlee, M. C., Laurberg, P., Maia, A. L., Rivkees, S. A., Samuels, M., Sosa, J. A., Stan, M. N., et al. (2016) · Thyroid® · doi:10.1089/thy.2016.0229 · Cited by 2,938
“The prevalence of hypothyroidism after RAI is progressive and hastened by the presence of antithyroid antibodies or a nonsuppressed TSH at the time of treatment (257,259,260).”
BackgroundBahn, R. S., Burch, H. B., Cooper, D. S., Garber, J. R., Greenlee, M. C., Klein, I., Laurberg, P., McDougall, I. R., Montori, V. M., Rivkees, S. A., et al. (2011) · Endocrine Practice · doi:10.4158/ep.17.3.456 · Cited by 1,098
The American Thyroid Association and American Association of Clinical Endocrinologists Taskforce on Hyperthyroidism and Other Causes of Thyrotoxicosis, Bahn, R. S., Burch, H. B., Cooper, D. S., Garber, J. R., Greenlee, M. C., Klein, I., Laurberg, P., McDougall, I. R., Montori, V. M., et al. (2011) · Thyroid · doi:10.1089/thy.2010.0417 · Cited by 898
Management of Simple Nodular Goiter: Current Status and Future Perspectives
Hegedűs, L. D., Bonnema, S. J., & Bennedbæk, F. N. (2003) · Endocrine Reviews · doi:10.1210/er.2002-0016 · Cited by 704
Iodide transport in the thyroid gland
Carrasco, N. (1993) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/0304-4157(93)90017-i · Cited by 365
Metadata
- Authors
- Goldstein, R., & Hart, I. R.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1983-12-15
- Volume
- 309
- Issue
- 24
- Pages
- 1473-1476
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2341027997
- Cited by
- 104
- References
- 14
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 2 · 2015: 2 · 2013: 1 · 2012: 1
- FWCI
- 2.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
- Keywords
- autonomously functioning thyroid nodules, iodine-131 therapy, long-term follow-up, hypothyroidism, nodule size, thyroid function, radioiodine therapy
- MeSH terms
- Adenoma, Adult, Evaluation Studies as Topic, Female, Follow-Up Studies, Humans, Hypothyroidism, Iodine Radioisotopes, Male, Middle Aged, Radiotherapy Dosage, Thyroid Diseases, Thyroid Gland, Thyroid Neoplasms
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