The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Some Speculations about Prions, Amyloid, and Alzheimer's Disease
Abstract
The causes of most degenerative diseases are unknown; however, the causes of three degenerative disorders of the central nervous system have been defined by their transmissibility to animals. These diseases are kuru, Creutzfeldt–Jakob disease, and the Gerstmann-Straüssler syndrome.1 , 2 The slow infectious agents that cause these diseases appear to be different from viruses but similar to the agent that causes scrapie, a neurologic disorder of sheep and goats.1 , 3 The term "prion" has been introduced to denote this slow infectious agent, with its unusual properties.3 Studies of the molecular structure of scrapie prions in highly purified preparations indicate that they contain one . . .
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“Pathologic similarities with prion disease suggest that the formation and spread of these proteinaceous lesions might involve a common molecular mechanism – corruptive protein templating.”
From Pathogenic protein seeding in Alzheimer disease and other neurodegenerative disorders (2011) · cites this paper as [2]
Citations
Cites
Novel Proteinaceous Infectious Particles Cause Scrapie
Prusiner, S. B. (1982) · Science · doi:10.1126/science.6801762 · Cited by 5,221
Self-citationAlzheimer's Disease: A Disorder of Cortical Cholinergic Innervation
Coyle, J. T., Price, D. L., & DeLong, M. R. (1983) · Science · doi:10.1126/science.6338589 · Cited by 3,055
Amyloid Deposits and Amyloidosis
Glenner, G. G. (1980) · New England Journal of Medicine · doi:10.1056/nejm198006053022305 · Cited by 1,780
Scrapie prions aggregate to form amyloid-like birefringent rods
Prusiner, S. B., McKinley, M. P., Bowman, K. A., Bolton, D. C., Bendheim, P. E., Groth, D., & Glenner, G. G. (1983) · Cell · doi:10.1016/0092-8674(83)90168-x · Cited by 1,052
Self-citationA protease-resistant protein is a structural component of the Scrapie prion
McKinley, M. P., Bolton, D. C., & Prusiner, S. B. (1983) · Cell · doi:10.1016/0092-8674(83)90207-6 · Cited by 925
Self-citationUnconventional Viruses and the Origin and Disappearance of Kuru
Gajdusek, D. C. (1977) · Science · doi:10.1126/science.142303 · Cited by 671
CREUTZFELDT-JAKOB DISEASE VIRUS ISOLATIONS FROM THE GERSTMANN-STRÄUSSLER SYNDROME
Masters, C. L., Gajdusek, D. C., & Gibbs, C. J. (1981) · Brain · doi:10.1093/brain/104.3.559 · Cited by 527
Abnormal fibrils from scrapie-infected brain
MERZ, P. A., Somerville, R. A., Wı́sniewski, H. M., & Iqbal, K. (1981) · Acta Neuropathologica · doi:10.1007/bf00691333 · Cited by 468
Further purification and characterization of scrapie prions
Prusiner, S. B., Bolton, D. C., Groth, D., Bowman, K. A., Cochran, S. P., & McKinley, M. P. (1982) · Biochemistry · doi:10.1021/bi00269a050 · Cited by 463
Self-citationScrapie infectivity, fibrils and low molecular weight protein
Diringer, H., Gelderblom, H., Hilmert, H., Özel, M., Edelbluth, C., & Kimberlin, R. H. (1983) · Nature · doi:10.1038/306476a0 · Cited by 340
Research works printed but not linked: 1
- Beck E, Daniel FM. Kuru and Creutzfeldt-Jakob disease; neuropathological lesions and their significance. In: Prusiner SB, Hadlow WJ. eds. Slow transmissible diseases of the nervous system. Vol. 1. New York: Academic Press, 1979:253–70.
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Jarrett, J. T., & Lansbury, P. T. (1993) · Cell · doi:10.1016/0092-8674(93)90635-4 · Cited by 2,178
The hubs of the human connectome are generally implicated in the anatomy of brain disorders
Crossley, N. A., Mechelli, A., Scott, J., Carletti, F., Fox, P. T., McGuire, P., & Bullmore, E. T. (2014) · Brain · doi:10.1093/brain/awu132 · Cited by 1,166
Distinct Tau Prion Strains Propagate in Cells and Mice and Define Different Tauopathies
Sanders, D. W., Kaufman, S. K., DeVos, S. L., Sharma, A. M., Mirbaha, H., Li, A., Barker, S. J., Foley, A. C., Thorpe, J. R., Serpell, L. C., et al. (2014) · Neuron · doi:10.1016/j.neuron.2014.04.047 · Cited by 986
Proteopathic tau seeding predicts tauopathy in vivo
Holmes, B. B., Furman, J. L., Mahan, T. E., Yamasaki, T. R., Mirbaha, H., Eades, W. C., Belaygorod, L., Cairns, N. J., Holtzman, D. M., & Diamond, M. I. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1411649111 · Cited by 696
Neurodegenerative Diseases and Prions
Prusiner, S. B. (2001) · New England Journal of Medicine · doi:10.1056/nejm200105173442006 · Cited by 783
Self-citation
Metadata
- Authors
- Prusiner, S. B.
- Corresponding author
- Prusiner, Stanley B.
- ORCID
- Prusiner, Stanley B.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1984-03-08
- Volume
- 310
- Issue
- 10
- Pages
- 661-663
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2014908349
- Cited by
- 213
- References
- 19
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 9 · 2023: 5 · 2022: 1 · 2021: 10 · 2020: 4 · 2019: 11 · 2018: 4 · 2017: 11 · 2016: 6 · 2015: 9 · 2014: 4 · 2013: 9 · 2012: 10
- FWCI
- 9.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Prion Diseases and Protein Misfolding
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Internal Medicine › Amyloidosis: Diagnosis, Treatment, Outcomes
- Keywords
- prions, amyloid, Alzheimer's disease, prion disease, Creutzfeldt-Jakob disease, kuru, Gerstmann-Sträussler-Scheinker disease, scrapie
- MeSH terms
- Aged, Alzheimer Disease, Amyloid, Animals, Brain, Humans, Creutzfeldt-Jakob Syndrome, Prions, Slow Virus Diseases, Viral Proteins
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