The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Cutaneous Squamous-Cell Carcinoma in Patients Treated with PUVA
Abstract
A 5.7-year prospective study of 1380 patients treated for psoriasis with oral methoxsalen (8-methoxypsoralen) and ultraviolet A photochemotherapy (PUVA) revealed that after adjustment for exposures to ionizing radiation and topical tar preparations, the risk that cutaneous squamous-cell carcinoma would develop at least 22 months after the first exposure to PUVA was 12.8 times higher in patients exposed to a high dose than in those exposed to a low dose (95 per cent confidence interval, 5.8 to 28.5). No substantial dose-related increase was noted for basal-cell carcinoma. The dose-dependent risk of cutaneous squamous-cell carcinoma suggests that PUVA can act as an independent carcinogen. In our study, morbidity associated with these tumors has been limited, but further follow-up is needed. Meanwhile, patients treated with PUVA should be followed closely for the possible development of cutaneous squamous-cell carcinoma.
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Citations
Cites
Photochemotherapy of Psoriasis with Oral Methoxsalen and Longwave Ultraviolet Light
Parrish, J. A., Fitzpatrick, T. B., Tanenbaum, L., & Pathak, M. A. (1974) · New England Journal of Medicine · doi:10.1056/nejm197412052912301 · Cited by 1,376
Self-citation
Cited by
Cutaneous Squamous-Cell Carcinoma
Alam, M., & Ratner, D. (2001) · New England Journal of Medicine · doi:10.1056/nejm200103293441306 · Cited by 1,305
Kabat-Zinn, J., Wheeler, E., Light, T., Skillings, A., Scharf, M. J., Cropley, T. G., Hosmer, D., & Bernhard, J. D. (1998) · Psychosomatic Medicine · doi:10.1097/00006842-199809000-00020 · Cited by 826
Existing and potential applications of ultraviolet light in the food industry - a critical review
Bintsis, T., Litopoulou-Tzanetaki, E., & Robinson, R. K. (2000) · Journal of the Science of Food and Agriculture · doi:10.1002/(sici)1097-0010(20000501)80:6<637::aid-jsfa603>3.0.co;2-1 · Cited by 788
Greaves, M. W., & Weinstein, G. D. (1995) · New England Journal of Medicine · doi:10.1056/nejm199503023320907 · Cited by 512
Squamous cell carcinoma of the skin (excluding lip and oral mucosa)
Johnson, T. M., Rowe, D. E., Nelson, B. R., & Swanson, N. A. (1992) · Journal of the American Academy of Dermatology · doi:10.1016/0190-9622(92)70074-p · Cited by 414
Metadata
- Authors
- Stern, R. S., Laird, N., Melski, J., Parrish, J. A., Fitzpatrick, T. B., & Bleich, H. L.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1984-05-03
- Volume
- 310
- Issue
- 18
- Pages
- 1156-1161
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W1969186806
- Cited by
- 452
- References
- 1
- FWCI
- 19.49
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Cutaneous Squamous-Cell Carcinoma in Patients Treated with PUVA. https://app.cochat.ai/papers/10.1056/nejm198405033101805
- The paper
- Stern, R. S., Laird, N., Melski, J., Parrish, J. A., Fitzpatrick, T. B., & Bleich, H. L. (1984). Cutaneous Squamous-Cell Carcinoma in Patients Treated with PUVA. New England Journal of Medicine. https://doi.org/10.1056/nejm198405033101805
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
