Photochemotherapy of Psoriasis with Oral Methoxsalen and Longwave Ultraviolet Light
Abstract
Oral administration of a photoactive drug, 8-methoxypsoralen (methoxsalen), followed by exposure to a high-intensity, longwave ultraviolet-light system resulted in complete clearing of generalized psoriasis in 21 patients. In 16 of these cases, a paired comparison showed methoxsalen followed by longwave ultraviolet light to be more effective than conventional ultraviolet light. 8-Methoxypsoralen followed by exposure to longwave ultraviolet light has previously been shown to inhibit epidermal DNA synthesis; this may be its mechanism of action in psoriasis, a disorder characterized by an accelerated cell cycle and rate of DNA synthesis. The term photochemotherapy is used to emphasize the point that the effect on epidermal proliferation and the therapeutic response require the interaction of light and drug. (N Engl J Med 291:1207–1211, 1974)
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8-Methoxypsoralen and 5-methoxypsoralen are used in PUVA therapy for hyperproliferative skin diseases including psoriasis and vitiligo.
“Furocoumarins including bifunctional 8-methoxypsoralen (8-MOP) and 5-methoxypsoralen (5-MOP) are still used in the so-called ''psoralen plus UVA (PUVA)'' therapy of rather frequent hyperproliferative skin diseases, including psoriasis and vitiligo (153-155).”
From Photoinduced Damage to Cellular DNA: Direct and Photosensitized Reactions<sup>†</sup> (2012) · cites this paper as [153]
Cites
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- Authors
- Parrish, J. A., Fitzpatrick, T. B., Tanenbaum, L., & Pathak, M. A.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1974-12-05
- Volume
- 291
- Issue
- 23
- Pages
- 1207-1211
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2336000290
- Cited by
- 1,376
- References
- 26
- Citations by year
- 2026: 8 · 2025: 13 · 2024: 14 · 2023: 12 · 2022: 12 · 2021: 11 · 2020: 20 · 2019: 14 · 2018: 15 · 2017: 17 · 2016: 22 · 2015: 13 · 2014: 21 · 2013: 21 · 2012: 25
- FWCI
- 18.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Health Sciences › Medicine › Dermatology › Cutaneous lymphoproliferative disorders research
- Keywords
- psoriasis, photochemotherapy, 8-methoxypsoralen, PUVA, epidermal DNA synthesis, epidermal proliferation, oral psoralen
- MeSH terms
- Administration, Oral, Adult, Cell Division, Depression, Chemical, DNA, Humans, Methoxsalen, Psoriasis, Radiation Effects, Skin, Ultraviolet Therapy
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