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Peptide Leukotriene Release after Antigen Challenge in Patients Sensitive to Ragweed
Abstract
Slow-reacting substance of anaphylaxis (composed of leukotrienes C, D, and E) is released in vitro by the interaction of antigen and IgE antibody on human mast cells and basophils. When we challenged ragweed-sensitive patients intranasally with pollen grains, their clinical response was significantly correlated with the release of the peptide leukotrienes (P less than 0.001). Nonallergic subjects had neither symptoms nor leukotriene release. The leukotrienes were released in a dose-dependent fashion, with a peak mean level of 827 +/- 234 pg per 0.1 ml of a 10-ml nasal wash. High-performance liquid chromatography revealed the presence of leukotrienes C, D, and E, suggesting that nasal cells or fluids had the ability to degrade leukotriene C enzymatically. The in vivo release of these potent inflammatory mediators after exposure to pollen suggests that leukotrienes may have an important role in human allergic reactions.
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Citations
Cited by
Allergic Rhinitis and Its Impact on Asthma
Bousquet, J., van Cauwenberge, P., & Khaltaev, N. (2001) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2001.118891 · Cited by 3,588
Lewis (1990) · doi:10.1056/nejm199009063231006 · Cited by 1,200
Lipoxygenase and leukotriene pathways: biochemistry, biology, and roles in disease
Haeggström, J. Z., & Funk, C. D. (2011) · Chemical Reviews · doi:10.1021/cr200246d · Cited by 875
Galli, S. J. (2000) · Current Opinion in Hematology · doi:10.1097/00062752-200001000-00007 · Cited by 521
Grossman, J. (1997) · Chest · doi:10.1378/chest.111.2_supplement.11s · Cited by 447
Metadata
- Authors
- Creticos, P. S., Peters, S. P., Adkinson, N. F., Naclerio, R. M., Hayes, E. C., Norman, P. S., & Lichtenstein, L. M.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1984-06-21
- Volume
- 310
- Issue
- 25
- Pages
- 1626-1630
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2327878210
- Cited by
- 394
- References
- 0
- FWCI
- 12.91
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Peptide Leukotriene Release after Antigen Challenge in Patients Sensitive to Ragweed. https://app.cochat.ai/papers/10.1056/nejm198406213102502
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- Creticos, P. S., Peters, S. P., Adkinson, N. F., Naclerio, R. M., Hayes, E. C., Norman, P. S., & Lichtenstein, L. M. (1984). Peptide Leukotriene Release after Antigen Challenge in Patients Sensitive to Ragweed. New England Journal of Medicine. https://doi.org/10.1056/nejm198406213102502
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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