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Increased Plasma Histamine Concentrations after Food Challenges in Children with Atopic Dermatitis
Abstract
Thirty-three patients with atopic dermatitis underwent double-blind placebo-controlled food challenges for evaluation of the role of histamine in hypersensitivity to food. After suspect foods were eliminated for 10 days, oral challenges were performed with up to 8 g of dehydrated food. A total of 35 positive challenges elicited symptoms that were cutaneous (31), gastrointestinal (17), nasal (8), and respiratory (6) within 10 to 90 minutes. Forty-one food challenges were negative, and all 60 placebo challenges were negative. Only the group of patients with positive food challenges had a significant mean (+/- S.E.M.) rise in the plasma histamine concentration, from 296 +/- 80 pg per milliliter before challenge to 1055 +/- 356 after challenge (P less than 0.001). Rises in plasma histamine that were seen after these positive oral food challenges implicate mast-cell or basophil mediators in the pathogenesis of food allergy, including cutaneous changes in patients with atopic dermatitis.
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Cited by
Boyce, J. A., Assa'ad, A., Burks, A. W., Jones, S. M., Sampson, H. A., Wood, R. A., Plaut, M., Cooper, S. F., Fenton, M. J., Arshad, S. H., et al. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.10.008 · Cited by 2,350
Self-citationLeiferman, K. M., Ackerman, S. J., Sampson, H. A., Haugen, H. S., Venencie, P. Y., & Gleich, G. J. (1985) · New England Journal of Medicine · doi:10.1056/nejm198508013130502 · Cited by 408
Self-citationPathogenesis of atopic dermatitis
Leung, D. Y. M. (1999) · Journal of Allergy and Clinical Immunology · doi:10.1016/s0091-6749(99)70051-5 · Cited by 306
Systemic effects of local allergic disease
Togias, A. (2004) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2003.09.051 · Cited by 102
Psychological aspects of food allergy
Kelsay, K. (2003) · Current Allergy and Asthma Reports · doi:10.1007/s11882-003-0011-z · Cited by 31
Metadata
- Authors
- Sampson, H. A., & Jolie, P. L.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1984-08-09
- Volume
- 311
- Issue
- 6
- Pages
- 372-376
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2341229871
- Cited by
- 242
- References
- 0
- FWCI
- 7.13
- Type
- journal article
- Language
- en
- Open access
- closed
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- Sampson, H. A., & Jolie, P. L. (1984). Increased Plasma Histamine Concentrations after Food Challenges in Children with Atopic Dermatitis. New England Journal of Medicine. https://doi.org/10.1056/nejm198408093110605
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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