The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Dermal Deposition of Eosinophil-Granule Major Basic Protein in Atopic Dermatitis: Comparison with Onchocerciasis
Abstract
Although blood eosinophilia is commonly present in atopic dermatitis, accumulation of tissue eosinophils is not prominent. To determine whether eosinophil degranulation occurs in lesions of atopic dermatitis, we analyzed tissues by immunofluorescence for the presence of the eosinophil-granule major basic protein. Twenty biopsy specimens from 18 patients with atopic dermatitis were studied, and all showed major basic protein staining outside eosinophils. In 18 specimens, the staining was fibrillar, was located in the upper half of the dermis, and was similar to the distribution of elastic fibers. Twelve specimens with fibrillar staining also showed major basic protein staining in the form of extracellular granules. One specimen from unaffected skin showed minimal faint, fine, fluorescing fibrils, but there was marked deposition of the protein in affected skin. The fibrillar pattern of major basic protein staining in atopic dermatitis was very similar to that seen in lichenified lesions of untreated onchocerciasis. These results suggest that eosinophils commonly release granule proteins in the dermis and that assessment of eosinophil involvement in disease cannot be based simply on numbers of eosinophils in tissue.
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Citations
Cites
Diagnostic features of atopic dermatitis
Hanifin, J. M., & Rajka, G. (1980) · Acta Dermato-Venereologica · doi:10.2340/00015555924447 · Cited by 5,086
Cytotoxic Properties of the Eosinophil Major Basic Protein
Gleich, G. J., Frigas, E., Loegering, D. A., Wassom, D. L., & Steinmuller, D. (1979) · The Journal of Immunology · doi:10.4049/jimmunol.123.6.2925 · Cited by 596
Self-citationThe late phase of the immediate wheal and flare skin reaction. Its dependence upon IgE antibodies.
Solley, G. O., Gleich, G. J., Jordon, R. E., & Schroeter, A. L. (1976) · Journal of Clinical Investigation · doi:10.1172/jci108485 · Cited by 542
Self-citationFilley, W. V., Kephart, G. M., Holley, K. E., & Gleich, G. J. (1982) · The Lancet · doi:10.1016/s0140-6736(82)91152-7 · Cited by 521
Self-citationCytotoxic effects of the guinea pig eosinophil major basic protein on tracheal epithelium.
Frigas, E., Loegering, D. A., & Gleich, G. J. (1980) · PubMed · Cited by 436
Self-citationBASOPHILS IN ALLERGEN-INDUCED PATCH TEST SITES IN ATOPIC DERMATITIS
Mitchell, E. B., Chapman, M., Pope, F. M., Crow, J., Jouhal, S., & Platts-Mills, T. E. (1982) · The Lancet · doi:10.1016/s0140-6736(82)90379-8 · Cited by 416
The Structure Of Normal Skin And The Morphology Of Atopic Eczema
Mihm, M. C., Soter, N. A., Dvorak, H. F., & Austen, K. F. (1976) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12514346 · Cited by 382
Damage to Schistosomula of Schistosoma Mansoni Induced Directly by Eosinophil Major Basic Protein
Butterworth, A. E., Wassom, D. L., Gleich, G. J., Loegering, D. A., & David, J. R. (1979) · The Journal of Immunology · doi:10.4049/jimmunol.122.1.221 · Cited by 370
Self-citationEpisodic Angioedema Associated with Eosinophilia
Gleich, G. J., Schroeter, A. L., Marcoux, J. P., Sachs, M. I., O'Connell, E. J., & Kohler, P. F. (1984) · New England Journal of Medicine · doi:10.1056/nejm198406213102501 · Cited by 363
Self-citationRole of immediate food hypersensitivity in the pathogenesis of atopic dermatitis
Sampson, H. A. (1983) · Journal of Allergy and Clinical Immunology · doi:10.1016/0091-6749(83)90464-5 · Cited by 351
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Cited by
Spergel, J. M., Mizoguchi, E., Brewer, J. P., Martin, T. R., Bhan, A. K., & Geha, R. S. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1647 · Cited by 640
Cellular and molecular immunologic mechanisms in patients with atopic dermatitis
Werfel, T., Allam, J.-P., Biedermann, T., Eyerich, K., Gilles, S., Guttman-Yassky, E., Hoetzenecker, W., Knol, E., Simon, H.-U., Wollenberg, A., et al. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2016.06.010 · Cited by 594
Atopic dermatitis: Clinical relevance of food hypersensitivity reactions
Burks, A. W., Mallory, S. B., Williams, L. W., & Shirrell, M. A. (1988) · The Journal of Pediatrics · doi:10.1016/s0022-3476(88)80626-7 · Cited by 323
Pathogenesis of atopic dermatitis
Leung, D. Y. M. (1999) · Journal of Allergy and Clinical Immunology · doi:10.1016/s0091-6749(99)70051-5 · Cited by 306
Kim, H. S., Kim, J. H., Seo, Y. M., Chun, Y. H., Yoon, J.-S., Kim, H. H., Lee, J. S., & Kim, J. T. (2017) · Annals of Allergy, Asthma & Immunology · doi:10.1016/j.anai.2017.06.022 · Cited by 37
Metadata
- Authors
- Leiferman, K. M., Ackerman, S. J., Sampson, H. A., Haugen, H. S., Venencie, P. Y., & Gleich, G. J.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1985-08
- Volume
- 313
- Issue
- 5
- Pages
- 282-285
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W1964102602
- Cited by
- 408
- References
- 29
- FWCI
- 17.84
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Dermal Deposition of Eosinophil-Granule Major Basic Protein in Atopic Dermatitis: Comparison with Onchocerciasis. https://app.cochat.ai/papers/10.1056/nejm198508013130502
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- Leiferman, K. M., Ackerman, S. J., Sampson, H. A., Haugen, H. S., Venencie, P. Y., & Gleich, G. J. (1985). Dermal Deposition of Eosinophil-Granule Major Basic Protein in Atopic Dermatitis: Comparison with Onchocerciasis. New England Journal of Medicine. https://doi.org/10.1056/nejm198508013130502
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