Pheochromocytoma: Diagnosis, Localization and Management
Abstract
THE early diagnosis of pheochromocytoma is important, not only because it offers the possibility of curing hypertension but also because unrecognized pheochromocytoma is a potentially lethal condition. Hypertensive crisis or shock or both leading to death have been precipitated by drugs, anesthetic agents, parturition, or surgery for an unrelated condition. Moreover, 8 to 10 per cent of the tumors are malignant.The detection of pheochromocytoma requires a high degree of clinical alertness. Although rare cases have been reported in which the tumor was not associated with hypertension, especially in patients with familial tumors, elevation of blood pressure, either continuous or . . .
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A sensation of palpitation may stem from sinus tachycardia and/or increased cardiac contractility, both of which may have various causes: fever, anaemia, orthostatic hypotension, hyperthyroidism/thyreotoxicosis, postmenopausal syndrome, pregnancy, hypoglycaemia, hypovolaemia, pheochromocytoma, arteriovenous fistula, postural orthostatic tachycardia syndrome, among others.
“A sensation of palpitation may stem from sinus tachycardia and/or increased cardiac contractility, both of which may have various causes: fever, anaemia, orthostatic hypotension, hyperthyroidism/ thyreotoxicosis, postmenopausal syndrome, pregnancy, hypoglycaemia, hypovolaemia, pheochromocytoma, arteriovenous fistula, postural orthostatic tachycardia syndrome, among others.31 -39”
From Management of patients with palpitations: a position paper from the European Heart Rhythm Association (2011) · cites this paper as [33]
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References 24 · Cited by 471
- Authors
- Bravo, E. L., & Gifford, R. W.
- Affiliations
- Cleveland Clinic (US)
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1984-11-15
- Volume
- 311
- Issue
- 20
- Pages
- 1298-1303
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2038050785
- Cited by
- 471
- References
- 24
- Citations by year
- 2026: 1 · 2025: 1 · 2023: 3 · 2022: 1 · 2021: 7 · 2020: 7 · 2019: 6 · 2018: 4 · 2017: 3 · 2016: 2 · 2015: 3 · 2014: 5 · 2013: 9 · 2012: 9
- FWCI
- 29.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
- Health Sciences › Medicine › Epidemiology › Neuroendocrine Tumor Research Advances
- Keywords
- pheochromocytoma, hypertension, hypertensive crisis, tumor localization, diagnosis, malignant pheochromocytoma, familial pheochromocytoma, surgical complications, anesthesia complications
- MeSH terms
- Adrenal Gland Neoplasms, Adrenergic beta-Antagonists, Blood Pressure, Catecholamines, Clonidine, Glucagon, Humans, Hypotension, Metanephrine, Pheochromocytoma, Tomography, X-Ray Computed, Vanilmandelic Acid
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