Management of patients with palpitations: a position paper from the European Heart Rhythm Association
Open accessAbstract
### Aim of the document Palpitations are among the most common symptoms that prompt patients to consult general practitioners, cardiologists, or emergency healthcare services.1–4 Very often, however, the diagnostic and therapeutic management of this symptom proves to be poorly efficacious and somewhat frustrating for both the patient and the physician. Indeed, in many cases a definitive, or at least probable, diagnosis of the cause of palpitations is not reached and no specific therapy is initiated.5,6 This means that many patients continue to suffer recurrences of their symptoms, which impair their quality of life and mental balance, lead to the potential risk of adverse clinical events, and induce continual recourse to healthcare facilities. These difficulties stem from the fact that palpitations are generally a transitory symptom. Indeed, at the moment of clinical evaluation, the patient is often asymptomatic and the diagnostic evaluation focuses on the search for pathological conditions that may be responsible for the symptom. This gives rise to some uncertainty in establishing a cause–effect relationship between any anomalies that may be detected and the palpitations themselves. Moreover, as palpitations may be caused by a wide range of different physiological and pathological conditions, clinicians tend to apply a number of instrumental investigations, laboratory tests, and specialist examinations, which are both time-consuming and costly. Comparable, for example, to syncope, such an approach is warranted in selected patients, whereas other patients with palpitations may not require such careful follow-up. The initial clinical assessment should, therefore, include an educated estimation of the likelihood of a relevant underlying arrhythmia in a patient with palpitations (‘gatekeeper' function). The current management of patients with palpitations is guided chiefly by the clinical experience of the physician. Indeed, the literature lacks specific policy documents or recommendations regarding the most appropriate diagnostic work-up to be adopted in individual …
Verified 2026-10-09 · 1 reference not checked yet
AI snapshot
Written from the paper’s full text.
TL;DR
This European Heart Rhythm Association position paper provides expert advice for diagnosing and managing palpitations, emphasizing initial history, physical examination, and 12-lead ECG, with targeted second-level monitoring when arrhythmic cause is suspected. It synthesizes available evidence and clinical experience, noting that many recommendations lack strong scientific documentation.
Key findings
- Palpitations are very common: in primary care they account for 16% of symptoms prompting a general practitioner visit and are second only to chest pain as the presenting complaint for specialist cardiologic evaluation.
- In a prospective study of 190 patients by Weber and Kapoor, palpitations were due to arrhythmias in 41% (16% atrial fibrillation/flutter, 10% supraventricular tachycardia, 2% ventricular tachycardia), structural heart disease in 3%, psychosomatic disorders in 31%, systemic causes in 4%, and medication/illicit substances/stimulants in 6%; no specific cause was identified in 16%, 1-year mortality was 1.6%, and 77% had at least one recurrence.
- Recurrence affects quality of life: one-third reported impaired ability to attend to household chores, 19% reported diminished working capacity, and 12% had taken days off work.
- Diagnostic yield varies by monitoring: Holter sensitivity was 33–35% in patients with palpitations of unknown origin and 22% in a meta-analysis of seven studies; external loop/event recorders showed 66–83% diagnostic value; the RUP study found implantable loop recorders superior to conventional strategy (73% vs. 21%) with better cost/effectiveness.
Methods
- This is an EHRA position paper offering expert advice for diagnostic evaluation and management of palpitations, not a primary study or systematic review.
- It narratively synthesizes literature and clinical experience, includes a diagnostic flow-chart and tables, and cites studies such as Weber and Kapoor (190 patients), Barsky et al. (145 patients), and the RUP study.
- Main analysis is consensus-based narrative synthesis; no formal meta-analysis, systematic search, or evidence-grading method is described.
Limitations
- The paper states that the literature lacks specific policy documents or recommendations for the diagnostic work-up of palpitations, that many suggestions are based on clinical experience without scientific documentation, and that data on long-term prognosis, age/gender distribution, and clinical features are scarce or from small samples.
- It also notes limitations of ambulatory ECG monitoring: single-lead devices may not allow precise arrhythmia diagnosis, reflex bradyarrhythmias cannot always be distinguished from conduction-system disorders, and monitoring requires symptom recurrence.
- Evident from the text: as a position paper, recommendations reflect expert consensus rather than a systematic, graded evidence review.
Model-written summary. Check it against the paper before relying on it.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
0 of 157 cited sources checked · 0 supported · 0 flagged
- Premisecitation
Palpitations are among the most common symptoms that prompt patients to consult general practitioners, cardiologists, or emergency healthcare services.
“Palpitations are among the most common symptoms that prompt patients to consult general practitioners, cardiologists, or emergency healthcare services.1 -4”
Quote in the paperNot a substantial claim0 of 4 sources checked- cites [1] Mayou, 1998, Chest pain, palpitations and panic, J Psychosom Res source
Not checked in the free run.
- cites [2] Messineo, 1989, Ventricular ectopic activity: prevalence and risk, Am J Cardiol source
Not checked in the free run.
- cites [3] Kroenke, 1990, The prevalence of symptoms in medical outpatients and the adequacy of therapy, Arch Intern Med source
Not checked in the free run.
- cites [4] Knudson, 1987, The natural history of palpitations in a family practice, J Fam Pract
Not checked in the free run.
- Premisecitation
The causes of palpitations can be subdivided into five main groups: cardiac arrhythmias, structural heart diseases, psychosomatic disorders, systemic diseases, and effects of medical and recreational drugs.
“From the aetiological point of view, the causes of palpitations can be subdivided into five main groups (Table 1): cardiac arrhythmias, structural heart diseases, psychosomatic disorders, systemic diseases, and effects of medical and recreational drugs.3 -9”
Quote in the paperSubstantial claim0 of 7 sources checked- cites [3] Kroenke, 1990, The prevalence of symptoms in medical outpatients and the adequacy of therapy, Arch Intern Med source
Not checked in the free run.
- cites [4] Knudson, 1987, The natural history of palpitations in a family practice, J Fam Pract
Not checked in the free run.
- cites [5] Zimetbaum, 1998, Evaluation of patients with palpitations, New Engl J Med source
Not checked in the free run.
- cites [6] Giada, 2004, Diagnostic management of patients with palpitations of unknown origin, Ital Heart J
Not checked in the free run.
- cites [7] Brugada, 1993, Investigation of palpitations, Lancet source
Not checked in the free run.
- cites [8] Pickett, 2005, Palpitations: a proper evaluation and approach to effective medical therapy, Curr Cardiol Rep source
Not checked in the free run.
- cites [9] Abbott, 2005, Diagnostic approach to palpitations, Am Fam Physician
Not checked in the free run.
- Interpretationcitation
In patients with asymptomatic arrhythmias, relevant arrhythmias might not be adequately diagnosed and managed.
“Thus, in such patients, relevant arrhythmias might not be adequately diagnosed and managed.15”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [15] Flaker, 2005, Asymptomatic atrial fibrillation: demographic features and prognostic information from the Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) study, Am Heart J source
Not checked in the free run.
- Premisecitation
Some structural heart diseases can give rise to palpitations in the absence of true rhythm disorders, including mitral valve prolapse, severe mitral and aortic regurgitation, congenital heart disease with significant shunt, hypertrophic cardiomyopathy, and mechanical prosthetic valves.
“Some structural heart diseases can give rise to palpitations in the absence of true rhythm disorders.These include, among others, mitral valve prolapse, severe mitral and aortic regurgitation, congenital heart disease with significant shunt, hypertrophic cardiomyopathy, and mechanical prosthetic valves.18,19”
Quote in the paperNot a substantial claim0 of 2 sources checked- cites [18] Braunwald, 1992, Valvular heart disease
Not checked in the free run.
- cites [19] Deveraux, 1989, Mitral valve prolapse: causes, clinical manifestations, and management, Ann Int Med source
Not checked in the free run.
- Premisereasoning
When it is not possible to document the cardiac rhythm during palpitations, non-arrhythmic causes are regarded as probable, but not definitive.
“When it is not possible to document the cardiac rhythm during palpitations, non-arrhythmic causes are regarded as probable, but not definitive.”
Quote in the paperSubstantial claim
- Premisenone given
Bradyarrhythmias are more rarely perceived as palpitations: sinus pauses and severe sinus bradycardia in sick sinus syndrome, sudden onset of high-degree AV block, or intermittent left-bundle branch block.
“By contrast, bradyarrhythmias are more rarely perceived as palpitations: these arrhythmias comprise sinus pauses and severe sinus bradycardia seen in sick sinus syndrome, sudden onset of high-degree atrioventricular block, or of intermittent left-bundle branch block.”
Quote in the paperNot a substantial claim - Premisecitation
Any type of tachyarrhythmia, regardless of whether or not there is an underlying structural or arrhythmogenic heart disease, can give rise to palpitations.
“Any type of tachyarrhythmia, regardless of whether or not there is an underlying structural or arrhythmogenic heart disease, can give rise to palpitations: atrial extrasystole, ventricular extrasystole, tachycardias with regular ventricular activity (sinus tachycardia, atrioventricular node reentrant tachycardia, atrioventricular reentrant tachycardia, atrial flutter, atrial tachycardias), and”
Quote in the paperSubstantial claim0 of 2 sources checked- cites [16] Blomström-Lundqvist, 2003, ACC/AHA/ESC Guidelines for the management of patients with supraventricular arrhythmias—executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Develop Guidelines for the Management of Patients With Supraventricular Arrhythmias), Circulation source
Not checked in the free run.
- cites [17] Zipes, 2006, ACC/AHA/ESC 2006 Guidelines for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: a report of the American College of Cardiology/American Heart Association Task Force and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Develop Guidelines for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death): developed in collaboration with the European Heart Rhythm Association and the Heart Rhythm Society, Circulation source
Not checked in the free run.
- Premisecitation
According to the aetiological hierarchy, non-arrhythmic causes of palpitations emerge as definitive diagnoses only in cases in which the symptom-ECG correlation excludes the presence of rhythm disorders.
“Thus, according to this aetiological hierarchy, non-arrhythmic causes of palpitations emerge as definitive diagnoses only in cases in which the symptom-electrocardiogram (ECG) correlation excludes the presence of rhythm disorders.8”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [8] Pickett, 2005, Palpitations: a proper evaluation and approach to effective medical therapy, Curr Cardiol Rep source
Not checked in the free run.
- Premisecitation
The adrenergic hyperactivation connected with intense emotions and anxiety can, in itself, predispose the patient to supraventricular and/or ventricular arrhythmias.
“In addition, the adrenergic hyperactivation connected with intense emotions and anxiety can, in itself, predispose the patient to supraventricular and/or ventricular arrhythmias.25 -27”
Quote in the paperNot a substantial claim0 of 3 sources checked- cites [25] Lampert, 2002, Emotional and physical precipitants of ventricular arrhythmia, Circulation source
Not checked in the free run.
- cites [26] Ziegelstein, 2007, Acute emotional stress and cardiac arrhythmias, JAMA source
Not checked in the free run.
- cites [27] Eaker, 2004, Anger and hostility predict the development of atrial fibrillation in men in the Framingham offspring study, Circulation source
Not checked in the free run.
- Premisecitation
Cardiac arrhythmias and psychosomatic disorders are not mutually exclusive.
“It must be borne in mind, however, that cardiac arrhythmias and psychosomatic disorders are not mutually exclusive.5,24”
Quote in the paperSubstantial claim0 of 2 sources checked - Premisecitation
Stimulants such as caffeine and nicotine, or the use of illicit drugs (cocaine, heroin, amphetamines, LSD, synthetic drugs, cannabis, etc.) can lead to sympathetic hyperactivation and sinus tachycardia, even in young subjects without heart disease.
“Likewise, stimulants such as caffeine and nicotine, or the use of illicit drugs (cocaine, heroin, amphetamines, LSD, synthetic drugs, cannabis, etc.) can lead to sympathetic hyperactivation and sinus tachycardia, even in young subjects without heart disease.41,42”
Quote in the paperNot a substantial claim0 of 2 sources checked - Premisecitation
Drugs that prolong QT and predispose patients to torsades de pointes and other tachyarrhythmias, such as antidepressive drugs, besides provoking dizziness or syncope, may also induce arrhythmia-related palpitations.
“Drugs that prolong QT and predispose patients to torsades de pointes and other tachyarrhythmias, such as antidepressive drugs, besides provoking dizziness or syncope, may also induce arrhythmia-related palpitations.43,44”
Quote in the paperNot a substantial claim0 of 2 sources checked - Premisecitation
No specific cause of palpitations could be identified in 16% of the patients despite a thorough evaluation including the use of loop recorders.
“No specific cause of palpitations could be identified in 16% of the patients despite a thorough evaluation including the use of loop recorders.”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [47] Weber, 1996, Evaluations and outcomes of patients with palpitations, Am J Med source
Not checked in the free run.
- Premisecitation
Clinically significant arrhythmias such as atrial fibrillation/flutter or paroxysmal supraventricular tachycardias are also a frequent finding in patients with palpitations.
“Nevertheless, clinically significant arrhythmias such as atrial fibrillation/flutter or paroxysmal supraventricular tachycardias are also a frequent finding.45,46”
Quote in the paperNot a substantial claim0 of 2 sources checked- cites [45] Zimetbaum, 1997, Utility of patient-activated cardiac event recorders in general clinical practice, Am J Cardiol source
Not checked in the free run.
- cites [46] Wu, 2003, Utility of patient-activated cardiac event recorders in the detection of cardiac arrhythmias, Interv Card Electrophysiol source
Not checked in the free run.
- Premisecitation
In the study by Weber and Kapoor, male sex, description of an irregular heartbeat, history of heart disease, and event duration >5 min were found to be independent predictors of a cardiac aetiology.
“In the study by Weber and Kapoor, 47 male sex, description of an irregular heartbeat, history of heart disease, and event duration .5 min were found to be independent predictors of a cardiac aetiology.”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [47] Weber, 1996, Evaluations and outcomes of patients with palpitations, Am J Med source
Not checked in the free run.
- Premisecitation
According to case records, the prevalence of anxiety syndrome and panic attacks in patients with palpitations ranges from 15% to 31%.
“According to the case records, the prevalence of anxiety syndrome and panic attacks in patients with palpitations ranges from 15% to 31%.20 -22”
Quote in the paperNot a substantial claim0 of 3 sources checked- cites [20] Chignon, 1993, Panic disorder in cardiac outpatients, Am J Psychiatry source
Not checked in the free run.
- cites [21] Barsky, 1994, Psychiatric disorders in medical outpatients complaining of palpitations, J Gen Intern Med source
Not checked in the free run.
- cites [22] Barsky, 1994, Panic disorder, palpitations and awareness of cardiac activity, J Nerv Ment Dis source
Not checked in the free run.
- Premisecitation
Clinical characteristics of the patient, such as age, presence of heart disease, and ECG abnormalities, do not always allow the physician to identify a priori those cases in which palpitations are caused by clinically significant rhythm disorders.
“Moreover, clinical characteristics of the patient, such as age, presence of heart disease, and ECG abnormalities, do not always allow the physician to identify a priori those cases in which palpitations are caused by clinically significant rhythm disorders.8,47,48,52 -54”
Quote in the paperSubstantial claim0 of 6 sources checked- cites [8] Pickett, 2005, Palpitations: a proper evaluation and approach to effective medical therapy, Curr Cardiol Rep source
Not checked in the free run.
- cites [47] Weber, 1996, Evaluations and outcomes of patients with palpitations, Am J Med source
Not checked in the free run.
- cites [48] Thavendiranathan, 2009, Does this patient with palpitations have a cardiac arrhythmia?, JAMA source
Not checked in the free run.
- cites [52] Giada, 2007, Recurrent unexplained palpitations (RUP) study: comparison of implantable loop recorder versus conventional diagnostic strategy, J Am Coll Cardiol source
Not checked in the free run.
- cites [53] Fogel, 1997, Utility and cost of event recorders in the diagnosis of palpitations, presyncope and syncope, Am J Cardiol source
Not checked in the free run.
- cites [54] Krahn, 1998, Final results from a pilot study with an implantable loop recorder to determine the etiology of syncope in patients with negative noninvasive and invasive testing, Am J Cardiol source
Not checked in the free run.
- Premisecitation
Palpitations due to arrhythmias, in particular of ventricular origin, but also atrial fibrillation, are associated with different prognostic implications.
“On the one hand, depending on the clinical characteristics of the patient, palpitations due to arrhythmias, in particular of ventricular origin, but also atrial fibrillation, are associated with different prognostic implications.15 -17”
Quote in the paperSubstantial claim0 of 3 sources checked- cites [15] Flaker, 2005, Asymptomatic atrial fibrillation: demographic features and prognostic information from the Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) study, Am Heart J source
Not checked in the free run.
- cites [16] Blomström-Lundqvist, 2003, ACC/AHA/ESC Guidelines for the management of patients with supraventricular arrhythmias—executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Develop Guidelines for the Management of Patients With Supraventricular Arrhythmias), Circulation source
Not checked in the free run.
- cites [17] Zipes, 2006, ACC/AHA/ESC 2006 Guidelines for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: a report of the American College of Cardiology/American Heart Association Task Force and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Develop Guidelines for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death): developed in collaboration with the European Heart Rhythm Association and the Heart Rhythm Society, Circulation source
Not checked in the free run.
- Premisecitation
In patients without relevant heart disease, palpitations (especially if anxiety-related or extrasystolic) generally have a benign prognosis.
“On the other hand, in patients without relevant heart disease, palpitations (especially if anxiety-related or extrasystolic) generally have a benign prognosis.”
Quote in the paperSubstantial claim - Premisecitation
Palpitations are generally associated with low rates of mortality.
“Although palpitations are generally associated with low rates of mortality, 4,47”
Quote in the paperNot a substantial claim0 of 2 sources checked- cites [4] Knudson, 1987, The natural history of palpitations in a family practice, J Fam Pract
Not checked in the free run.
- cites [47] Weber, 1996, Evaluations and outcomes of patients with palpitations, Am J Med source
Not checked in the free run.
- Premisereasoning
The prognostic implications of palpitations are dependent on the underlying aetiology as well as clinical characteristics of the patient.
“The prognostic implications of palpitations are dependent on the underlying aetiology as well as clinical characteristics of the patient.”
Quote in the paperSubstantial claim - Premisecitation
A retrospective American study found no difference in 5-year mortality and morbidity between patients with palpitations and a group of asymptomatic control subjects.
“A retrospective American study that analysed case records obtained from general practitioners found no difference in 5-year mortality and morbidity between patients with palpitations and a group of asymptomatic control subjects.4”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [4] Knudson, 1987, The natural history of palpitations in a family practice, J Fam Pract
Not checked in the free run.
- Premisecitation
Even supraventricular arrhythmias, such as rapidly conducted preexcited atrial fibrillation during exertion, can have potentially life-threatening haemodynamic consequences.
“because of potentially life-threatening haemodynamic consequences of even supraventricular arrhythmias, such as rapidly conducted preexcited atrial fibrillation during exertion”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [57] Pelliccia, 2008, Bethesda Conference #36 and the European Society of Cardiology consensus recommendations revisited: a comparison of U.S. and European criteria for eligibility and disqualification of competitive athletes with cardiovascular abnormalities, J Am Coll Cardiol source
Not checked in the free run.
- Premisenone given
Extrasystolic palpitations, due to ectopic beats, generally produce feelings of 'missing/skipping a beat' and/or a 'sinking of the heart' interspersed with periods during which the heart beats normally.
“Extrasystolic palpitations, due to ectopic beats, generally produce feelings of 'missing/skipping a beat' and/or a 'sinking of the heart' interspersed with periods during which the heart beats normally; patients report that the heart seems to stop and then start again, causing an unpleasant, almost painful, sensation of a blow to the chest.”
Quote in the paperNot a substantial claim - Premisecitation
The most common descriptions, and those most useful in clinical practice in differential diagnoses among the various causes of palpitations, enable palpitations to be classified according to the rate, rhythm, and intensity of heartbeat: extrasystolic palpitations, tachycardiac palpitations, anxiety-related palpitations, and pulsation palpitations.
“The most common descriptions, and those most useful in clinical practice in differential diagnoses among the various causes of palpitations, enable palpitations to be classified according to the rate, rhythm, and intensity of heartbeat 5 -9,59,60 : extrasystolic palpitations, tachycardiac palpitations, anxiety-related palpitations, and pulsation palpitations (Table 2).”
Quote in the paperNot a substantial claim0 of 7 sources checked- cites [5] Zimetbaum, 1998, Evaluation of patients with palpitations, New Engl J Med source
Not checked in the free run.
- cites [6] Giada, 2004, Diagnostic management of patients with palpitations of unknown origin, Ital Heart J
Not checked in the free run.
- cites [7] Brugada, 1993, Investigation of palpitations, Lancet source
Not checked in the free run.
- cites [8] Pickett, 2005, Palpitations: a proper evaluation and approach to effective medical therapy, Curr Cardiol Rep source
Not checked in the free run.
- cites [9] Abbott, 2005, Diagnostic approach to palpitations, Am Fam Physician
Not checked in the free run.
- cites [59] Hlatky, 1998, Approach to the patient with palpitations
Not checked in the free run.
- cites [60] Zipes, 1995, Assessment of patients with cardiac arrhythmia
Not checked in the free run.
- Premisecitation
The sensation of a rapid, regular pulse in the neck (usually associated with the 'frog sign') raises suspicion of supraventricular tachycardia, particularly atrioventricular nodal reentrant tachycardia.
“By contrast, the sensation of a rapid, regular pulse in the neck (usually associated with the 'frog sign') raises suspicion of supraventricular tachycardia, particularly atrioventricular nodal reentrant tachycardia.64”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [64] González-Torrecilla, 2009, Combined evaluation of bedside clinical variables and the electrocardiogram for the differential diagnosis of paroxysmal atrioventricular reciprocating tachycardias in patients without pre-excitation, J Am Coll Cardiol source
Not checked in the free run.
- Premisecitation
Syncope may also occur at the onset of supraventricular tachycardia in patients with a normal heart, as the result of the triggering of a vasovagal reaction.
“However, syncope may also occur at the onset of supraventricular tachycardia in patients with a normal heart, as the result of the triggering of a vasovagal reaction.62”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [62] Leitch, 1992, Syncope associated with supraventricular tachycardia. An expression of tachycardia rate or vasomotor response?, Circulation source
Not checked in the free run.
- Premisenone given
The occurrence of syncope or other symptoms, such as severe fatigue, dyspnoea, or angina, in addition to palpitations, is much more frequent in patients with structural heart disease.
“The occurrence of syncope or other symptoms, such as severe fatigue, dyspnoea, or angina, in addition to palpitations, is much more frequent in patients with structural heart disease.”
Quote in the paperNot a substantial claim - Premisecitation
The utility of the features on history for diagnosing an arrhythmic cause of palpitations has been examined in a recent systematic review.
“The utility of the features on history for diagnosing an arrhythmic cause of palpitations has been examined in a recent systematic review.48”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [48] Thavendiranathan, 2009, Does this patient with palpitations have a cardiac arrhythmia?, JAMA source
Not checked in the free run.
- Premisecitation
Certain symptoms and circumstances associated to palpitations are often connected with the various causes of the palpitations and may be very helpful in making differential diagnoses.
“Certain symptoms and circumstances associated to palpitations are often connected with the various causes of the palpitations and may be very helpful in making differential diagnoses.5 -9,59,60”
Quote in the paperSubstantial claim0 of 7 sources checked- cites [5] Zimetbaum, 1998, Evaluation of patients with palpitations, New Engl J Med source
Not checked in the free run.
- cites [6] Giada, 2004, Diagnostic management of patients with palpitations of unknown origin, Ital Heart J
Not checked in the free run.
- cites [7] Brugada, 1993, Investigation of palpitations, Lancet source
Not checked in the free run.
- cites [8] Pickett, 2005, Palpitations: a proper evaluation and approach to effective medical therapy, Curr Cardiol Rep source
Not checked in the free run.
- cites [9] Abbott, 2005, Diagnostic approach to palpitations, Am Fam Physician
Not checked in the free run.
- cites [59] Hlatky, 1998, Approach to the patient with palpitations
Not checked in the free run.
- cites [60] Zipes, 1995, Assessment of patients with cardiac arrhythmia
Not checked in the free run.
- Premisenone given
Data on the utility of clinical features for diagnosing arrhythmic cause come from studies with small sample sizes.
“However, data in this regard come from studies with small sample sizes.”
Quote in the paperSubstantial claim - Premisecitation
External and implantable loop recorders, mobile cardiac outpatient telemetry, and pacemakers and ICDs can detect asymptomatic clinically significant arrhythmias automatically, without patient activation.
“The external and implantable loop recorders, mobile cardiac outpatient telemetry, and pacemakers and ICDs can detect asymptomatic clinically significant arrhythmias automatically (i.e. with no activation by the patient)”
Quote in the paperSubstantial claim0 of 8 sources checked- cites [49] Hoefman, 2007, Predictive value of history taking and physical examination in diagnosing arrhythmias in general practice, Fam Pract source
Not checked in the free run.
- cites [73] Olson, 2007, Utility of mobile outpatient telemetry for the diagnosis of palpitations, presyncope, syncope, and the assessment of therapy efficacy, J Cardiovasc Electrophsiol source
Not checked in the free run.
- cites [74] Rothman, 2007, The diagnosis of cardiac arrhythmias: a prospective multi-center randomized study comparing mobile cardiac outpatient telemetry versus standard loop event monitoring, J Cardiovasc Electrophysiol source
Not checked in the free run.
- cites [75] Reiffel, 1991, Optimum duration of transtelephonic ECG monitoring when used for transient symptomatic event detection, J Electrocardiol source
Not checked in the free run.
- cites [76] Kinlay, 1996, Cardiac event recorders yield more diagnoses and are more cost-effective than 48-hour Holter monitoring in patients with palpitations, Ann Intern Med source
Not checked in the free run.
- cites [77] Scalvini, 2005, Cardiac event recording yields more diagnoses than 24-hour Holter monitoring in patients with palpitations, J Telemed Telecare source
Not checked in the free run.
- cites [78] Brown, 1987, Detection of arrhythmias: use of a patient-activated ambulatory electrocardiogram device with a solid-state memory loop, Br Heart J source
Not checked in the free run.
- cites [79] Antman, 1988, Transtelephonic electrocardiographic transmission for management of cardiac arrhythmias, Am J Cardiol source
Not checked in the free run.
- Premisecitation
Event recorders or handheld patient-operated ECG systems improve the diagnosis of transient ECG changes in patients with palpitations.
“Event recorders or handheld patient-operated ECG systems have been shown to improve the diagnosis of transient ECG changes in patients with palpitations.71,72”
Quote in the paperSubstantial claim0 of 2 sources checked- cites [71] Scherr, 2008, Prospective comparison of the diagnostic utility of a standard event monitor versus a ‘leadless’ portable ECG monitor in the evaluation of patients with palpitations, J Interv Card Electrophysiol source
Not checked in the free run.
- cites [72] Kaleschke, 2009, Prospective, multicentre validation of a simple, patient-operated electrocardiographic system for the detection of arrhythmias and electrocardiographic changes, Europace source
Not checked in the free run.
- Premisecitation
Other features such as underlying history of panic disorder and duration of palpitations less than 5 min appear to be useful for ruling out a clinically significant arrhythmia.
“Other features such as underlying history of panic disorder and duration of palpitations less than 5 min appear to be useful for ruling out a clinically significant arrhythmia.47”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [47] Weber, 1996, Evaluations and outcomes of patients with palpitations, Am J Med source
Not checked in the free run.
- Interpretationcitation
In the absence of electrocardiographic recording during an episode of palpitations, only a presumed or probable diagnosis can be made.
“It should be underlined, however, that, in the absence of electrocardiographic recording during an episode of palpitations, only a presumed or probable diagnosis can be made.30”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [30] Lessmeier, 1997, Unrecognized paroxysmal supraventricular tachycardia. Potential for misdiagnosis as panic disorder, Arch Intern Med source
Not checked in the free run.
- Premisecitation
External and implantable loop recorders, mobile cardiac outpatient telemetry, and pacemakers and ICDs provide a significantly higher yield than standard patient-activated loop recorders in patients with infrequent palpitations.
“and provide a significantly higher yield than standard patient-activated loop recorders in patients with infrequent palpitations.49,73 -79”
Quote in the paperSubstantial claim0 of 8 sources checked- cites [49] Hoefman, 2007, Predictive value of history taking and physical examination in diagnosing arrhythmias in general practice, Fam Pract source
Not checked in the free run.
- cites [73] Olson, 2007, Utility of mobile outpatient telemetry for the diagnosis of palpitations, presyncope, syncope, and the assessment of therapy efficacy, J Cardiovasc Electrophsiol source
Not checked in the free run.
- cites [74] Rothman, 2007, The diagnosis of cardiac arrhythmias: a prospective multi-center randomized study comparing mobile cardiac outpatient telemetry versus standard loop event monitoring, J Cardiovasc Electrophysiol source
Not checked in the free run.
- cites [75] Reiffel, 1991, Optimum duration of transtelephonic ECG monitoring when used for transient symptomatic event detection, J Electrocardiol source
Not checked in the free run.
- cites [76] Kinlay, 1996, Cardiac event recorders yield more diagnoses and are more cost-effective than 48-hour Holter monitoring in patients with palpitations, Ann Intern Med source
Not checked in the free run.
- cites [77] Scalvini, 2005, Cardiac event recording yields more diagnoses than 24-hour Holter monitoring in patients with palpitations, J Telemed Telecare source
Not checked in the free run.
- cites [78] Brown, 1987, Detection of arrhythmias: use of a patient-activated ambulatory electrocardiogram device with a solid-state memory loop, Br Heart J source
Not checked in the free run.
- cites [79] Antman, 1988, Transtelephonic electrocardiographic transmission for management of cardiac arrhythmias, Am J Cardiol source
Not checked in the free run.
- Premisecitation
In patients with palpitations of unknown origin, Holter monitoring has a low sensitivity (33-35%).
“In patients with palpitations of unknown origin, Holter monitoring has displayed a rather low sensitivity value (33-35%).81”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [81] Zimtbaum, 1999, The evolving role of ambulatory arrhythmia monitoring in general practice, Ann Intern Med source
Not checked in the free run.
- Premisecitation
ILRs can be useful in the study of palpitations of unknown origin.
“and they can be useful in the study of palpitations of unknown origin.69,88,89”
Quote in the paperSubstantial claim0 of 3 sources checked- cites [69] Crawford, 1999, ACC/AHA Guidelines for ambulatory electrocardiography—executive summary and recommendations: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to Revise the Guidelines for Ambulatory Electrocardiography), Circulation source
Not checked in the free run.
- cites [88] Waktare, 2001, Holter and event recordings for arrhythmia detection
Not checked in the free run.
- cites [89] Paisey, 2005, Implantable loop recorders detect tachyarrhythmias in symptomatic patients with negative electrophysiological studies, Int J Cardiol source
Not checked in the free run.
- Premisecitation
In a meta-analysis of seven studies of patients with syncope and/or palpitations of unknown origin, Holter monitoring has a sensitivity of only 22%.
“In a meta-analysis of seven studies conducted on patients with syncope and/or palpitations of unknown origin, Holter monitoring has been seen to have a sensitivity value of only 22%.82”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [82] Di Marco, 1990, Use of ambulatory electrocardiographic (Holter) monitoring, Ann Intern Med source
Not checked in the free run.
- Interpretationnone given
The ability to detect the onset of an arrhythmic episode provides valuable information on the mechanism of the arrhythmias.
“Moreover, the ability to detect the onset of the episode provides valuable information on the mechanism of the arrhythmias.”
Quote in the paperNot a substantial claim - Premisecitation
In patients with symptoms of possible arrhythmic origin, mobile cardiac outpatient telemetry has higher diagnostic value than other external devices.
“Finally, in patients with symptoms of possible arrhythmic origin, mobile cardiac outpatient telemetry has been seen to exhibit a higher diagnostic value than the other external devices.71,84,85”
Quote in the paperSubstantial claim0 of 3 sources checked- cites [71] Scherr, 2008, Prospective comparison of the diagnostic utility of a standard event monitor versus a ‘leadless’ portable ECG monitor in the evaluation of patients with palpitations, J Interv Card Electrophysiol source
Not checked in the free run.
- cites [84] Hoefman, 2007, Optimal duration of event recording for diagnosis of arrhythmias in patients with palpitations and light-headedness in the general practice, Fam Pract source
Not checked in the free run.
- cites [85] Joshi, 2005, First exeprience with a Mobile Cardiac Outpatient Telemetry (MCOT) system for the diagnosis and management of cardiac arrhythmias, Am J Cardiol source
Not checked in the free run.
- Premisenone given
The sensitivity of ambulatory ECG monitoring is extremely variable and depends on monitoring technique, duration, patient compliance, and most importantly the frequency of attacks.
“whereas the sensitivity is extremely variable and depends on the following factors: the monitoring techniques used, the duration of monitoring, patient compliance, and, most importantly, the frequency of the attacks.”
Quote in the paperSubstantial claim - Interpretationreasoning
In patients who do not develop symptoms during ambulatory ECG monitoring, the examination is often non-contributory.
“In patients who do not develop symptoms during monitoring, therefore, this examination is often non-contributory.”
Quote in the paperSubstantial claim - Premisecitation
According to ACC/AHA guidelines, recurrent palpitations of unknown origin are a class-I indication for long-term ECG monitoring.
“According to the ACC/AHA guidelines for the use of ambulatory ECG monitoring, 69,70 recurrent palpitations of unknown origin constitute a class-I indication for long-term ECG monitoring.”
Quote in the paperSubstantial claim0 of 2 sources checked- cites [69] Crawford, 1999, ACC/AHA Guidelines for ambulatory electrocardiography—executive summary and recommendations: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to Revise the Guidelines for Ambulatory Electrocardiography), Circulation source
Not checked in the free run.
- cites [70] Kadish, 2001, ACC/AHA clinical competence statement on electrocardiography and ambulatory electrocardiography: a report of the ACC/AHA/ACP-ASIM Task Force on Clinical Competence (ACC/AHA Committee to Develop a Clinical Competence Statement on Electrocardiography and Ambulatory Electrocardiography), endorsed by the International Society for Holter and Noninvasive Electrocardiology, J Am Coll Cardiol source
Not checked in the free run.
- Premisenone given
EPS enables ablative therapy of induced tachyarrhythmias during the same session as diagnosis.
“Moreover, it enables ablative therapy of the induced tachyarrhythmias to be performed during the same session in which the diagnosis is made.”
Quote in the paperSubstantial claim - Premisecitation
Atrial fibrillation is associated with an increased risk of thromboembolism, especially in patients with risk factors included in the CHA2DS2VASc score.
“It is well known that atrial fibrillation is associated with an increased risk of thromboembolism, especially in patients with certain risk factors as those considered in the CHA 2 DS 2 VASc risk score.14”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [14] Camm, 2010, Guidelines for the management of atrial fibrillation. The task force for the management of atrial fibrillation of the European Society of Cardiology, Eur Heart J
Not checked in the free run.
- Premisecitation
A substantial percentage (6-35%) of arrhythmias diagnosed in patients with palpitations of unknown origin who undergo ambulatory ECG monitoring are clinically significant, such as supraventricular tachycardias and atrial fibrillation.
“a substantial percentage (6-35%) of the arrhythmias diagnosed prove to be clinically significant, such as supraventricular tachycardias and atrial fibrillation.5”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [5] Zimetbaum, 1998, Evaluation of patients with palpitations, New Engl J Med source
Not checked in the free run.
- Premisereasoning
Ambulatory ECG monitoring may have difficulty differentiating supraventricular tachycardia with aberrant conduction from ventricular tachycardia.
“For example, it may be difficult to make a correct differential diagnosis between a supraventricular tachycardia with aberrant conduction and a ventricular tachycardia.”
Quote in the paperSubstantial claim - Premisenone given
EPS can correctly identify the type of arrhythmia responsible for palpitations.
“First of all, it is able to correctly identify the type of arrhythmia responsible for the palpitations.”
Quote in the paperNot a substantial claim - Premisereasoning
Ambulatory ECG monitoring is not always able to formulate a precise diagnosis of the type of arrhythmia recorded, especially with single-lead ECG devices.
“Indeed, it is not always possible to formulate a precise diagnosis of the type of arrhythmia recorded, especially when single-lead ECG devices are used.”
Quote in the paperSubstantial claim - Premisecitation
In patients implanted with pacemakers or ICDs, interrogating the device memory can provide useful information on the origin of palpitations.
“In patients implanted with pacemakers or ICDs, useful information on the origin of palpitations can be obtained by interrogating the memory of the device.90”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [90] Epstein, 2008, ACC/AHA/HRS 2008 guidelines for device-based therapy of cardiac rhythm abnormalities: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the ACC/AHA/NASPE 2002 Guideline Update for Implantation of Cardiac Pacemakers and Antiarrhythmia Devices): developed in collaboration with the American Association for Thoracic Surgery and Society of Thoracic Surgeons, Circulation
Not checked in the free run.
- Premisecitation
A small percentage of patients with palpitations of unknown origin have major bradyarrhythmic disorders, such as severe sinus bradycardia and paroxysmal advanced atrioventricular block.
“Finally, a small percentage of patients with palpitations of unknown origin have major bradyarrhythmic disorders, such as severe sinus bradycardia and paroxysmal advanced atrioventricular block.52,71”
Quote in the paperNot a substantial claim0 of 2 sources checked- cites [52] Giada, 2007, Recurrent unexplained palpitations (RUP) study: comparison of implantable loop recorder versus conventional diagnostic strategy, J Am Coll Cardiol source
Not checked in the free run.
- cites [71] Scherr, 2008, Prospective comparison of the diagnostic utility of a standard event monitor versus a ‘leadless’ portable ECG monitor in the evaluation of patients with palpitations, J Interv Card Electrophysiol source
Not checked in the free run.
- Premisecitation
High-intensity endurance sport practice has been related to an increased risk of atrial fibrillation.
“On the other hand, high-intensity endurance sport practice has been related to an increased risk of atrial fibrillation.96”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [96] Mont, 2010, Arrhythmias and sport practice, Heart source
Not checked in the free run.
- Premisecitation
Vagal manoeuvres and pharmacological tests (e.g., intravenous adenosine or ajmaline) during ECG recording can unmask atrial activity or interrupt tachycardia, resulting in diagnosis of the arrhythmia type.
“Vagal manoeuvres and pharmacological tests, such as intravenous adenosine or ajmaline, performed during ECG recording are of major interest as they can unmask the atrial activity or interrupt suddenly the tachycardia, resulting in the diagnosis of the type of arrhythmia.16,68”
Quote in the paperSubstantial claim0 of 2 sources checked- cites [16] Blomström-Lundqvist, 2003, ACC/AHA/ESC Guidelines for the management of patients with supraventricular arrhythmias—executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Develop Guidelines for the Management of Patients With Supraventricular Arrhythmias), Circulation source
Not checked in the free run.
- cites [68] Brembilla-Perrot, 2010, Pharmacological testing in the diagnosis of arrhythmias, Minerva Cardioangiol
Not checked in the free run.
- Premisereasoning
Ambulatory ECG monitoring serves to document cardiac rhythm during an episode of palpitations when standard ECG cannot, as in short-lasting symptoms.
“Ambulatory ECG monitoring serves to document the cardiac rhythm during an episode of palpitations if this cannot be done by means of standard ECG, as in the case of short-lasting symptoms.”
Quote in the paperSubstantial claim - Premisenone given
Description of the type of palpitations (regular or not, rapid or not) can help determine the underlying mechanism.
“Description of the type of palpitations (regular or not, rapid or not) could help to determine its underlying mechanism (Table 2).”
Quote in the paperSubstantial claim - Premisecitation
The vast majority of patients with palpitations can be assessed in an outpatient setting.
“The vast majority of patients with palpitations can be assessed in an outpatient setting.”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [47] Weber, 1996, Evaluations and outcomes of patients with palpitations, Am J Med source
Not checked in the free run.
- Premisecitation
In the study by Weber and Kapoor, EPS and haemodynamic study were performed in only 5% of patients.
“In the study by Weber and Kapoor, 47 an EPS and a haemodynamic study were performed in only 5% of patients.”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [47] Weber, 1996, Evaluations and outcomes of patients with palpitations, Am J Med source
Not checked in the free run.
- Classified as probably not a substantial claim. 21
- The quote only partly states this claim. 1
- May combine two claims. 41
Probably not a substantial claim: may not pass S3 (load-bearing), S4 (based).
Findingnone givenHolter monitoring is low cost.
“Low cost”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing), S4 (based).
Findingnone givenEvent recorders are low cost.
“Low cost; easy to use”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Findingnone givenImplantable loop recorders are invasive.
“Invasiveness”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing), S4 (based).
Findingnone givenEvent recorders produce poor ECG records.
“poor ECG records”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing), S4 (based). The quote only partly states this claim.
Findingnone givenPacemakers/ICDs have high costs.
“high costs”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Findingnone givenPacemakers/ICDs are invasive.
“Invasiveness”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Findingnone givenEvent recorders are easy to use.
“Low cost; easy to use”
Quote in the paperNot a substantial claimMay combine two claims.
InterpretationreasoningUncertainty arises in establishing a cause-effect relationship between any anomalies detected and the palpitations themselves because palpitations are transitory and the patient is often asymptomatic at evaluation.
“This gives rise to some uncertainty in establishing a cause -effect relationship between any anomalies that may be detected and the palpitations themselves.”
Quote in the paperSubstantial claim- Rests on an assumption: Palpitations are generally a transitory symptom.
- Rests on an assumption: At the moment of clinical evaluation, the patient is often asymptomatic.
May combine two claims.
PremisecitationAlthough cardiac rhythm disorders generally give rise to palpitations, in some subjects arrhythmias including prognostically relevant disorders such as non-sustained ventricular tachycardias and atrial fibrillation may remain completely asymptomatic.
“It is important to underline the fact that, although cardiac rhythm disorders generally give rise to palpitations (or other related symptoms, such as fatigue, dyspnoea, dizziness, syncope, and angina), in some subjects, for reasons not entirely known but probably linked to some clinical characteristics (long-standing arrhythmias with relatively low maximum ventricular rate, male sex, absence of”
Quote in the paperNot a substantial claim0 of 4 sources checked- cites [11] Sugishita, 2003, Diabetes influences the cardiac symptoms related to atrial fibrillation, Circ J source
Not checked in the free run.
- cites [13] Kirchhof, 2007, Outcome parameters for trials in atrial fibrillation, Europace source
Not checked in the free run.
- cites [14] Camm, 2010, Guidelines for the management of atrial fibrillation. The task force for the management of atrial fibrillation of the European Society of Cardiology, Eur Heart J
Not checked in the free run.
- cites [15] Flaker, 2005, Asymptomatic atrial fibrillation: demographic features and prognostic information from the Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) study, Am Heart J source
Not checked in the free run.
May combine two claims.
PremisecitationIn many cases, a definitive or at least probable diagnosis of the cause of palpitations is not reached and no specific therapy is initiated.
“Indeed, in many cases a definitive, or at least probable, diagnosis of the cause of palpitations is not reached and no specific therapy is initiated.5,6”
Quote in the paperSubstantial claim0 of 2 sources checked- cites [5] Zimetbaum, 1998, Evaluation of patients with palpitations, New Engl J Med source
Not checked in the free run.
- cites [6] Giada, 2004, Diagnostic management of patients with palpitations of unknown origin, Ital Heart J
Not checked in the free run.
Probably not a substantial claim: may not pass S4 (based).
Premisenone givenPalpitations may be caused by a wide range of different physiological and pathological conditions.
“Moreover, as palpitations may be caused by a wide range of different physiological and pathological conditions, clinicians tend to apply a number of instrumental investigations, laboratory tests, and specialist examinations, which are both time-consuming and costly.”
Quote in the paperNot a substantial claimMay combine two claims.
InterpretationreasoningMany patients with palpitations continue to suffer recurrences of symptoms, which impair quality of life and mental balance, lead to potential risk of adverse clinical events, and induce continual recourse to healthcare facilities.
“This means that many patients continue to suffer recurrences of their symptoms, which impair their quality of life and mental balance, lead to the potential risk of adverse clinical events, and induce continual recourse to healthcare facilities.”
Quote in the paperSubstantial claimMay combine two claims.
PremisereasoningElectrocardiographic documentation of a rhythm disorder during spontaneous symptoms provides the strongest evidence of causality; whenever this proves possible, the palpitations are classified as being of arrhythmic origin.
“Electrocardiographic documentation of a rhythm disorder during spontaneous symptoms provides the strongest evidence of causality; whenever this proves possible, therefore, the palpitations are classified as being of arrhythmic origin.”
Quote in the paperSubstantial claim- Rests on an assumption: Electrocardiographic documentation of a rhythm disorder during spontaneous symptoms provides the strongest evidence of causality.
Probably not a substantial claim: may not pass S3 (load-bearing), S4 (based).
Premisenone givenIt is not uncommon for a patient to have more than one potential cause or type of palpitation.
“It is not uncommon, however, for the patient to have more than one potential cause or type of palpitation.”
Quote in the paperNot a substantial claimMay combine two claims.
PremisecitationPsychosomatic disorders most frequently associated with palpitations include anxiety, panic attacks, depression, and somatization, which can either induce sinus tachycardia or modify the patient's subjective perception of a heartbeat that is otherwise normal or presents minimal irregularities.
“Psychosomatic disorders that are most frequently associated with palpitations include anxiety, panic attacks, depression, and somatization, which can either induce sinus tachycardia or modify the patient's subjective perception of a heartbeat that is otherwise normal or presents minimal irregularities.20 -23”
Quote in the paperSubstantial claim0 of 4 sources checked- cites [20] Chignon, 1993, Panic disorder in cardiac outpatients, Am J Psychiatry source
Not checked in the free run.
- cites [21] Barsky, 1994, Psychiatric disorders in medical outpatients complaining of palpitations, J Gen Intern Med source
Not checked in the free run.
- cites [22] Barsky, 1994, Panic disorder, palpitations and awareness of cardiac activity, J Nerv Ment Dis source
Not checked in the free run.
- cites [23] Jeejeebhoy, 2000, Panic disorder and the heart: a cardiology perspective, J Psychosom Res source
Not checked in the free run.
Classified as probably not a substantial claim.
PremisereasoningPalpitations are considered to be of non-arrhythmic origin when the underlying heart rhythm exhibits sinus rhythm or sinus tachycardia.
“By contrast, they are considered to be of non-arrhythmic origin when the underlying heart rhythm exhibits sinus rhythm or sinus tachycardia.”
Quote in the paperSubstantial claimMay combine two claims.
PremisecitationSome studies suggest that anxiety exerts a facilitating effect on arrhythmogenesis as well as on the patient's perception of the arrhythmia.
“Indeed, in the last few years, some studies investigating the correlation between anxiety syndrome and the appearance of arrhythmias have suggested that anxiety exerts a facilitating effect on arrhythmogenesis 28 as well as on the patient's perception of the arrhythmia.29”
Quote in the paperNot a substantial claim0 of 2 sources checked- cites [28] Tavazzi, 1986, The role of psychologic stress in the genesis of lethal arrhythmias in patients with coronary artery disease, Eur Heart J
Not checked in the free run.
- cites [29] Domschke, 2010, Coincidence of paroxysmal supraventricular tachycardia and panic disorders: two case reports, Ann Gen Psych source
Not checked in the free run.
May combine two claims.
PremisecitationA sensation of palpitation may stem from sinus tachycardia and/or increased cardiac contractility, both of which may have various causes: fever, anaemia, orthostatic hypotension, hyperthyroidism/thyreotoxicosis, postmenopausal syndrome, pregnancy, hypoglycaemia, hypovolaemia, pheochromocytoma, arteriovenous fistula, postural orthostatic tachycardia syndrome, among others.
“A sensation of palpitation may stem from sinus tachycardia and/or increased cardiac contractility, both of which may have various causes: fever, anaemia, orthostatic hypotension, hyperthyroidism/ thyreotoxicosis, postmenopausal syndrome, pregnancy, hypoglycaemia, hypovolaemia, pheochromocytoma, arteriovenous fistula, postural orthostatic tachycardia syndrome, among others.31 -39”
Quote in the paperNot a substantial claim0 of 9 sources checked- cites [31] Cryer, 1985, Glucose counterregulation, hypoglycemia, and intensive insulin therapy in diabetes mellitus, N Engl J Med source
Not checked in the free run.
- cites [32] Klein, 1990, Thyroid hormone and the cardiovascular system, Am J Med source
Not checked in the free run.
- cites [33] Bravo, 1984, Pheocromocitoma: diagnosis, localization and management, N Engl J Med source
Not checked in the free run.
- cites [34] Rosenthal, 1992, Hematological–oncological disorders and heart disease
Not checked in the free run.
- cites [35] Elkayam, 1992, Pregnancy and cardiovascular disease
Not checked in the free run.
- cites [36] Dinardello, 1990, Fever
Not checked in the free run.
- cites [37] Holman, 1966, Abnormal arteriovenous communications. Great variability of effects with particular reference to delayed development of cardiac failure, Circulation source
Not checked in the free run.
- cites [38] Moya, 2009, Guidelines for the diagnosis and management of syncope. The Task Force for the Diagnosis and Management of Syncope of the European Society of Cardiology (ESC). Developed in collaboration with European Heart Rhythm Association (EHRA), Heart Failure Association (HFA), and Heart Rhythm Society (HRS), Eur Heart J source
Not checked in the free run.
- cites [39] Thomas, 1981, Orthostatic hypotension, Mayo Clin Proc source
Not checked in the free run.
May combine two claims.
PremisecitationIn a study conducted on patients with documented supraventricular tachycardia, two-thirds had previously been wrongly diagnosed as suffering from panic attack disorder, and the diagnosed 'psychosomatic disease' could be cured by catheter ablation in most of these patients.
“Finally, in a study conducted on patients with documented supraventricular tachycardia, it was found that two-thirds had previously been wrongly diagnosed as suffering from panic attack disorder, and that the diagnosed 'psychosomatic disease' could be cured by catheter ablation in most of these patients.30”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [30] Lessmeier, 1997, Unrecognized paroxysmal supraventricular tachycardia. Potential for misdiagnosis as panic disorder, Arch Intern Med source
Not checked in the free run.
Probably not a substantial claim: may not pass S3 (load-bearing), S4 (based). May combine two claims.
Premisenone givenThe prevalence of palpitations is dependent on definitions and diagnostic methods used and varies substantially in different populations.
“The prevalence of palpitations is dependent on definitions and diagnostic methods used and varies substantially in different populations.”
Quote in the paperNot a substantial claimMay combine two claims.
PremisecitationIn studies in primary care settings, palpitations account for 16% of the symptoms that prompt patients to visit their general practitioner, and are second only to chest pain as the presenting complaint for specialist cardiologic evaluation.
“In studies in primary care settings, palpitations account for 16% of the symptoms that prompt patients to visit their general practitioner, and are second only to chest pain as the presenting complaint for specialist cardiologic evaluation.1,3,4”
Quote in the paperNot a substantial claim0 of 3 sources checked- cites [1] Mayou, 1998, Chest pain, palpitations and panic, J Psychosom Res source
Not checked in the free run.
- cites [3] Kroenke, 1990, The prevalence of symptoms in medical outpatients and the adequacy of therapy, Arch Intern Med source
Not checked in the free run.
- cites [4] Knudson, 1987, The natural history of palpitations in a family practice, J Fam Pract
Not checked in the free run.
May combine two claims.
PremisecitationIn cases of drug-induced palpitations, palpitations may be linked to sinus tachycardia; drugs involved include sympathomimetics, anticholinergics, vasodilators, and hydralazine.
“In such cases, palpitations may be linked to sinus tachycardia; drugs involved include sympathomimetics, anticholinergics, vasodilators, and hydralazine.40”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [40] Naranjo, 1981, A method for estimating the probabilty of adverse drug reaction, Clin Pharmacol Ther source
Not checked in the free run.
May combine two claims.
PremisecitationThere is evidence that palpitations are a very frequent symptom in the general population and, in particular, in patients suffering from hypertension or heart disease.
“Nevertheless, there is evidence that palpitations are a very frequent symptom in the general population 2,9 and, in particular, in patients suffering from hypertension or heart disease.”
Quote in the paperNot a substantial claim0 of 2 sources checked- cites [2] Messineo, 1989, Ventricular ectopic activity: prevalence and risk, Am J Cardiol source
Not checked in the free run.
- cites [9] Abbott, 2005, Diagnostic approach to palpitations, Am Fam Physician
Not checked in the free run.
May combine two claims.
PremisecitationIn a prospective study by Weber and Kapoor in 190 patients presenting with a complaint of palpitations at a university medical centre, palpitations were due to arrhythmias in 41% (16% atrial fibrillation/flutter, 10% supraventricular tachycardia, 2% ventricular tachycardia), to structural heart disease in 3%, to psychosomatic disorders in 31% (mainly panic and anxiety disorders), to systemic cases
“In a prospective study by Weber and Kapoor 47 in 190 patients presenting with a complaint of palpitations at an university medical centre, palpitations were due to arrhythmias in 41% of these patients (16% of whom had atrial fibrillation/flutter, 10% had supraventricular tachycardia, and 2% had ventricular tachycardia), to structural heart disease in 3%, to psychosomatic disorders in 31% (mainly”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [47] Weber, 1996, Evaluations and outcomes of patients with palpitations, Am J Med source
Not checked in the free run.
May combine two claims.
PremisecitationIt is not always possible to establish a definite cause of palpitations; often, only a likely cause can be given, and, in some cases, several possible causes have to be taken into consideration.
“Indeed, it is not always possible to establish a definite cause of palpitations; often, only a likely cause can be given, and, in some cases, several possible causes have to be taken into consideration.8,42”
Quote in the paperNot a substantial claim0 of 2 sources checkedMay combine two claims.
PremisecitationIn general, older patients and men are more likely to have an arrhythmic cause of palpitations and younger patients and women a psychosomatic cause.
“In general, however, older patients and men are more likely to have an arrhythmic cause of palpitations and younger patients and women a psychosomatic cause.47 -51”
Quote in the paperNot a substantial claim0 of 5 sources checked- cites [47] Weber, 1996, Evaluations and outcomes of patients with palpitations, Am J Med source
Not checked in the free run.
- cites [48] Thavendiranathan, 2009, Does this patient with palpitations have a cardiac arrhythmia?, JAMA source
Not checked in the free run.
- cites [49] Hoefman, 2007, Predictive value of history taking and physical examination in diagnosing arrhythmias in general practice, Fam Pract source
Not checked in the free run.
- cites [50] Summerton, 2001, New-onset palpitations in general practice: assessing the discriminant value of items within the clinical history, Fam Pract source
Not checked in the free run.
- cites [51] Mayou, 2003, Characteristics of patients presenting to a cardiac clinic with palpitations, Q J Med source
Not checked in the free run.
Probably not a substantial claim: may not pass S3 (load-bearing).
Premisenone givenIn athletes, palpitations are not uncommon.
“In athletes, palpitations are not uncommon.”
Quote in the paperNot a substantial claimMay combine two claims.
Premisenone givenEven in patients without severe heart disease, palpitations may be due to significant arrhythmias, such as atrial fibrillation, atrial flutter, or ventricular ectopic beats, all of which require adequate investigation and treatment.
“However, even in patients without severe heart disease, palpitations may be due to significant arrhythmias, such as atrial fibrillation, atrial flutter, or ventricular ectopic beats, all of which require adequate investigation and treatment.”
Quote in the paperSubstantial claimMay combine two claims.
PremisecitationIn the study by Weber and Kapoor, 77% of patients experienced at least one recurrence of palpitations, and the effect on their quality of life was unfavourable: one-third reported impairment of ability to attend to household chores, 19% claimed working capacity diminished, and 12% said they had taken days off work.
“In the study by Weber and Kapoor, 47 77% of patients experienced at least one recurrence of palpitations, and the effect on their quality of life was unfavourable: one-third of patients reported an impairment of their ability to attend to household chores, 19% claimed that their working capacity had diminished, and 12% said that they had taken days off work.”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [47] Weber, 1996, Evaluations and outcomes of patients with palpitations, Am J Med source
Not checked in the free run.
May combine two claims.
PremisecitationSudden death, in particular in younger athletes, is rare and mostly associated with underlying structural heart disease or primary arrhythmic disorders, and palpitations may be the initial clinical symptom or an incidental finding possibly leading to the recognition of a previously undiagnosed relevant heart disease.
“Sudden death, in particular in younger athletes, is rare and mostly associated with underlying structural heart disease or primary arrhythmic disorders, and palpitations may be the initial clinical symptom or an incidental finding possibly leading to the recognition of a previously undiagnosed relevant heart disease.55,56”
Quote in the paperNot a substantial claim0 of 2 sources checked- cites [55] Pelliccia, 2005, Recommendations for competitive sports participation in athletes with cardiovascular disease: a consensus document from the Study Group of Sports Cardiology of the Working Group of Cardiac Rehabilitation and Exercise Physiology and the Working Group of Myocardial and Pericardial Diseases of the European Society of Cardiology, Eur Heart J source
Not checked in the free run.
- cites [56] Delise, 2005, Cardiological guidelines for competitive sports eligibility, Ital Heart J
Not checked in the free run.
May combine two claims.
PremisecitationAlthough palpitations display a low mortality rate, the recurrence of symptoms is very frequent.
“Although palpitations display a low mortality rate, the recurrence of symptoms is, however, very frequent.”
Quote in the paperNot a substantial claimMay combine two claims.
PremisecitationPatients are not always able to describe the characteristics of their symptoms precisely; it may therefore be difficult to identify the type of palpitation accurately, especially in the case of normal-rate palpitations.
“It should, however, be stressed that patients are not always able to describe the characteristics of their symptoms precisely.It may therefore be difficult to identify the type of palpitation accurately, especially in the case of normalrate palpitations.5,9,61”
Quote in the paperNot a substantial claim0 of 3 sources checked- cites [5] Zimetbaum, 1998, Evaluation of patients with palpitations, New Engl J Med source
Not checked in the free run.
- cites [9] Abbott, 2005, Diagnostic approach to palpitations, Am Fam Physician
Not checked in the free run.
- cites [61] Leitch, 1991, Can patients discriminate between atrial fibrillation and regular supraventricular tachycardia?, Am J Cardiol source
Not checked in the free run.
May combine two claims.
PremisecitationIn many respects, palpitations seem to behave like a chronic disorder that has a favourable prognosis, but with periodic attacks followed by transitory remission.
“In many respects, palpitations seem to behave like a chronic disorder that has a favourable prognosis, but with periodic attacks followed by transitory remission.3,4”
Quote in the paperNot a substantial claim0 of 2 sources checked- cites [3] Kroenke, 1990, The prevalence of symptoms in medical outpatients and the adequacy of therapy, Arch Intern Med source
Not checked in the free run.
- cites [4] Knudson, 1987, The natural history of palpitations in a family practice, J Fam Pract
Not checked in the free run.
May combine two claims.
PremisecitationFrequent and recurrent palpitations can impair the patient's quality of life, giving rise to anxiety and frequent visits to the emergency department.
“Frequent and recurrent palpitations, therefore, can impair the patient's quality of life, giving rise to anxiety and frequent visits to the emergency department.3”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [3] Kroenke, 1990, The prevalence of symptoms in medical outpatients and the adequacy of therapy, Arch Intern Med source
Not checked in the free run.
Probably not a substantial claim: may not pass S3 (load-bearing), S4 (based). May combine two claims.
Premisenone givenPulsation palpitations tend to be persistent and are generally linked to structural heart diseases, such as aortic regurgitation, or to systemic causes involving a high stroke volume, such as fever and anaemia.
“They tend to be persistent and are generally linked to structural heart diseases, such as aortic regurgitation, or to systemic causes involving a high stroke volume, such as fever and anaemia.”
Quote in the paperNot a substantial claimMay combine two claims.
Premisenone givenTachycardiac palpitations are generally linked to supraventricular or ventricular tachyarrhythmias, which begin and usually end suddenly, or to sinus tachycardia due to systemic causes or to the use of drugs or illicit substances (in these cases, palpitations begin and end gradually).
“These palpitations are generally linked to supraventricular or ventricular tachyarrhythmias, which begin and usually end suddenly (sometimes the termination is gradual due to the increase in sympathetic tone during tachycardia that tends to persist and declines slowly after its interruption), or to sinus tachycardia due to systemic causes or to the use of drugs or illicit substances (in these”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing), S4 (based).
Premisenone givenEpisodes of paroxysmal atrial fibrillation may occur in the phase immediately following the cessation of physical effort, during which a sudden reduction in sympathetic tone is accompanied by an increase in vagal tone.
“Finally, episodes of paroxysmal atrial fibrillation may occur in the phase immediately following the cessation of physical effort, during which a sudden reduction in sympathetic tone is accompanied by an increase in vagal tone.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing), S4 (based).
Premisenone givenPalpitations that arise in situations of anxiety or during panic attacks are generally due to episodes of more or less rapid sinus tachycardia secondary to the mental disturbance.
“Palpitations that arise in situations of anxiety or during panic attacks are generally due to episodes of more or less rapid sinus tachycardia secondary to the mental disturbance.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing), S4 (based). May combine two claims.
PremisereasoningDuring physical exercise, due to an increase in the sympathetic drive, patients may experience, in addition to the normal sensation of a rapid heart rate elicited by intense effort, palpitations due to various types of arrhythmia, such as right ventricular outflow tract tachycardia, atrioventricular node reentrant tachycardia, and polymorphic catecholaminergic ventricular tachycardia.
“During physical exercise, due to an increase in the sympathetic drive, patients may experience, in addition to the normal sensation of a rapid heart rate elicited by intense effort, palpitations due to various types of arrhythmia, such as right ventricular outflow tract tachycardia, atrioventricular node reentrant tachycardia, and polymorphic catecholaminergic ventricular tachycardia.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing), S4 (based).
Premisenone givenPolyuria, which is due to the hypersecretion of natriuretic hormone, is typical of atrial tachyarrhythmias, particularly atrial fibrillation.
“Polyuria, which is due to the hypersecretion of natriuretic hormone, is typical of atrial tachyarrhythmias, particularly atrial fibrillation.”
Quote in the paperNot a substantial claimMay combine two claims.
Premisenone givenPalpitations arising after sudden changes in posture are frequently due to intolerance to orthostatis or to episodes of atrioventricular nodal reentrant tachycardia.
“Palpitations arising after sudden changes in posture are frequently due to intolerance to orthostatis or to episodes of atrioventricular nodal reentrant tachycardia.”
Quote in the paperNot a substantial claimMay combine two claims.
Premisenone givenExtrasystolic palpitations are frequently encountered even in young subjects, often in the absence of heart disease, and generally have a benign prognosis.
“Linked to the presence of atrial or ventricular extrasystolic beats, this type of palpitation is frequently encountered even in young subjects, often in the absence of heart disease, and generally has a benign prognosis.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing), S4 (based). May combine two claims.
Premisenone givenAnxiety-related palpitations are due to psychosomatic disorders and usually require exclusion of an arrhythmic cause of the symptoms.
“Anxiety-related palpitations are due to psychosomatic disorders and usually require exclusion of an arrhythmic cause of the symptoms.”
Quote in the paperNot a substantial claimMay combine two claims.
PremisecitationThe initial clinical evaluation leads to a definitive or probable diagnosis of the cause of the palpitations in about half of patients, and excludes with reasonable certainty the presence of causes that have an unfavourable prognosis.
“The initial clinical evaluation leads to a definitive or probable diagnosis of the cause of the palpitations in about half of patients, and excludes with reasonable certainty the presence of causes that have an unfavourable prognosis.47”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [47] Weber, 1996, Evaluations and outcomes of patients with palpitations, Am J Med source
Not checked in the free run.
Classified as probably not a substantial claim.
Premisenone givenA thorough initial clinical evaluation will indicate which specific investigations, if any, are necessary.
“Moreover, a thorough initial clinical evaluation will indicate which specific investigations, if any, are necessary.”
Quote in the paperSubstantial claimMay combine two claims.
PremisecitationThe likelihood ratio of each feature for diagnosing an arrhythmic cause of palpitations is, in general, low and only a few features are really predictive. They include history of cardiac disease, palpitations affected by sleeping, or while the patient is at work.
“The likelihood ratio of each feature is, in general, low and only a few features are really predictive.They include history of cardiac disease, palpitations affected by sleeping, or while the patient is at work.”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [48] Thavendiranathan, 2009, Does this patient with palpitations have a cardiac arrhythmia?, JAMA source
Not checked in the free run.
May combine two claims.
Premisenone givenMany of the latest diagnostic systems allow automatic detection of arrhythmias and immediate wireless transmission of ECG data to a central monitoring station.
“Another major benefit of the latest diagnostic systems is that many of them not only allow automatic detection of the arrhythmias but also allow immediate wireless transmission of pertinent ECG data to a central monitoring station via a mobile telephone line or the Internet.”
Quote in the paperNot a substantial claimMay combine two claims.
PremisecitationILRs have been successfully used to study syncope and have a better cost/effectiveness ratio than conventional tests.
“ILRs have been successfully used to study syncope, in which they have shown a better cost/effectiveness ratio than the conventional tests, 86,87”
Quote in the paperNot a substantial claim0 of 2 sources checked- cites [86] Krahn, 1999, The high cost of syncope: cost implications of a new insertable loop recorder in the investigation of recurrent syncope, Am Heart J source
Not checked in the free run.
- cites [87] Krahn, 2001, Randomized assessment of syncope trial: conventional diagnostic testing versus a prolonged monitoring strategy, Circulation source
Not checked in the free run.
May combine two claims.
PremisecitationIn patients with daily or weekly symptoms, external loop recorders and event recorders have higher diagnostic value (66-83%) and better cost/effectiveness than Holter devices.
“By contrast, in patients in whom the symptoms are quite frequent (i.e.daily or weekly), external loop recorders and event recorders have shown both a higher diagnostic value (66 -83%) and a better cost/effectiveness ratio than Holter devices.71,83”
Quote in the paperSubstantial claim0 of 2 sources checked- cites [71] Scherr, 2008, Prospective comparison of the diagnostic utility of a standard event monitor versus a ‘leadless’ portable ECG monitor in the evaluation of patients with palpitations, J Interv Card Electrophysiol source
Not checked in the free run.
- cites [83] Zimetbaum, 1998, Diagnostic yield and optimal duration of continuous-loop event monitoring for the diagnosis of palpitations, Ann Intern Med source
Not checked in the free run.
May combine two claims.
Interpretationnone givenAmbulatory ECG monitoring requires the patient to experience a recurrence of symptoms, which delays diagnosis and may expose patients with malignant arrhythmias to adverse events.
“Finally, ambulatory ECG monitoring requires the patient to experience a recurrence of symptoms.This delays the diagnosis and, should the palpitations be due to malignant arrhythmias, exposes the patient to the potential risk of adverse events.”
Quote in the paperSubstantial claimMay combine two claims.
PremisecitationOnce atrial fibrillation has been diagnosed as a cause of palpitations, there is limited data on the importance of assessing atrial fibrillation burden for evaluating thromboembolic risk, and more information is needed.
“However, it must be underlined that once atrial fibrillation has been diagnosed as a cause of palpitations, there is up to now only limited data on the importance of assessing atrial fibrillation burden for the evaluation of thromboembolic risk, and more information is still needed.67,91”
Quote in the paperNot a substantial claim0 of 2 sources checked- cites [67] Botto, 2009, Presence and duration of atrial fibrillation detected by continuous monitoring: crucial implications for the risk of thromboembolic events, J Cardiovasc Electrophysiol source
Not checked in the free run.
- cites [91] Glotzer, 2009, The relationship between daily atrial tachyarrhythmia burden from implantable device diagnostics and stroke risk. The TRENDS Study, Circ Arrhythm Electrophysiol source
Not checked in the free run.
May combine two claims.
InterpretationreasoningEPS enables diagnosis and specific therapy to be initiated immediately, whereas ambulatory ECG monitoring requires symptom recurrence.
“Finally, while EPS enables a diagnosis to be made and specific therapy to be initiated immediately, ambulatory ECG monitoring requires the patient to experience a recurrence of symptoms.”
Quote in the paperSubstantial claimMay combine two claims.
Premisereasoning12-lead ECG during palpitations allows analysis of P and QRS morphologies, their relationship, and heart rhythm frequency and regularity, and provides an accurate diagnosis of concordance between palpitations and presence or absence of arrhythmia.
“It allows the physician to analyse P and QRS morphologies and the relationship between these two waves, and the frequency and regularity of the heart rhythm, and finally brings an accurate diagnosis on the concordance between palpitations and the presence or absence of arrhythmia.”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Premisenone givenIn some instances, such as evident pre-excitation with reported rapid regular palpitations, the diagnosis is formal even if tachycardia has never been recorded.
“In some instances, for example in case of evident pre-excitation when the patient reports rapid regular palpitations, the diagnosis is formal even if tachycardia has never been recorded.”
Quote in the paperNot a substantial claimMay combine two claims.
PremisereasoningPrecise analysis of ECG during arrhythmia either provides the mechanism or gives important data leading to the diagnosis.
“Furthermore, precise analysis of ECG during arrhythmia either provides the mechanism or gives important data that lead to this diagnosis.”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S4 (based).
Premisenone givenCircumstances during which palpitations occur are generally helpful to evaluate their cause.
“Circumstances during which palpitations have occurred are generally helpful to evaluate their cause.”
Quote in the paperNot a substantial claimMay combine two claims.
Premisenone givenP waves during rapid tachycardia are not always visible, making diagnosis difficult.
“It should be stressed, however, that P waves during rapid tachycardia are not always visible, making the diagnosis difficult.”
Quote in the paperSubstantial claimMay combine two claims.
PremisecitationVagal manoeuvres such as carotid sinus massage can guide the differential diagnosis of tachycardias: sudden interruption suggests AV junctional tachycardia, while temporary reduction suggests atrial fibrillation, flutter, or atrial tachycardia.
“The differential diagnosis of various types of tachycardia may be guided by vagal manoeuvres 68 such as carotid sinus massage: sudden interruption of the tachycardia is highly suggestive of a tachycardia involving the atrioventricular junction whereas a temporary reduction of the frequency is suggestive of atrial fibrillation, flutter, or atrial tachycardia (Table 3).”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [68] Brembilla-Perrot, 2010, Pharmacological testing in the diagnosis of arrhythmias, Minerva Cardioangiol
Not checked in the free run.
The paper relies on this without support.
Palpitations are generally a transitory symptom.
“These difficulties stem from the fact that palpitations are generally a transitory symptom.”
The paper relies on this without support.
At the moment of clinical evaluation, the patient is often asymptomatic.
“Indeed, at the moment of clinical evaluation, the patient is often asymptomatic and the diagnostic evaluation focuses on the search for pathological conditions that may be responsible for the symptom.”
The paper relies on this without support.
The current management of patients with palpitations is guided chiefly by the clinical experience of the physician.
“The current management of patients with palpitations is guided chiefly by the clinical experience of the physician.”
The paper relies on this without support.
The literature lacks specific policy documents or recommendations regarding the most appropriate diagnostic work-up to be adopted in individual patients.
“Indeed, the literature lacks specific policy documents or recommendations regarding the most appropriate diagnostic work-up to be adopted in individual patients.”
The paper relies on this without support.
Electrocardiographic documentation of a rhythm disorder during spontaneous symptoms provides the strongest evidence of causality.
“Electrocardiographic documentation of a rhythm disorder during spontaneous symptoms provides the strongest evidence of causality; whenever this proves possible, therefore, the palpitations are classified as being of arrhythmic origin.”
The paper relies on this without support.
In patients with palpitations of unknown origin, gradual onset, absence of significant heart disease, and anxiety-related or extrasystolic palpitations indicate a low probability of an arrhythmic cause.
“In subjects with palpitations of unknown origin who have a low probability of an arrhythmic cause (i.e.patients with gradual onset of palpitations and without significant heart disease and those with anxiety-related or extrasystolic palpitations), further investigations are often not required.”
The paper relies on this without support.
The patient's description of symptoms can reliably establish that they match palpitations and are not confused with other chest manifestations.
“The first step is to establish that symptoms described by the patient match to palpitations and are not confused with chest pain or other manifestations arising in the chest, but that do not correspond to the definition of palpitations described in this article.”
The paper relies on this without support.
12-lead ECG recorded during palpitations is the diagnostic gold standard.
“If the patient is examined during palpitations, 12-lead ECG represents the diagnostic gold standard.”
The paper relies on this without support.
The specificity of ambulatory ECG monitoring for diagnosing arrhythmic versus nonarrhythmic palpitations is optimal.
“The specificity of ambulatory ECG monitoring, at least in formulating a diagnosis of arrhythmic palpitations or nonarrhythmic palpitations, is optimal”
The paper relies on this without support.
Ventricular tachycardia is much less common and is typical of patients with structural or arrhythmogenic heart diseases.
“Ventricular tachycardia is much less common and is typical of patients with structural or arrhythmogenic heart diseases.”
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Recommended first-line investigation with 12-lead ECG and conventional ambulatory monitoring (Holter or event monitoring) are of limited efficacy due to the infrequency of symptoms in many patients.
“Recommended first line investigation of 12-lead ECG [4] and conventional ambulatory monitoring (Holter or event monitoring) [5], [6] are of limited efficacy due to the infrequency of symptoms in many patients [5], [7], [8], [9], [10].”
From Multi-centre Randomised Controlled Trial of a Smartphone-based Event Recorder Alongside Standard Care Versus Standard Care for Patients Presenting to the Emergency Department with Palpitations and Pre-syncope: The IPED (Investigation of Palpitations in the ED) study (2019) · cites this paper as [5]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
Each contradiction between two passages listed here was confirmed by an independent check.
Sinus tachycardia classified as both arrhythmic and non-arrhythmic
MinorThe paper says palpitations accompanied by sinus tachycardia are considered non-arrhythmic, but later lists sinus tachycardia among the tachyarrhythmias that cause palpitations.
“By contrast, they are considered to be of non-arrhythmic origin when the underlying heart rhythm exhibits sinus rhythm or sinus tachycardia.”
“Any type of tachyarrhythmia, regardless of whether or not there is an underlying structural or arrhythmogenic heart disease, can give rise to palpitations: atrial extrasystole, ventricular extrasystole, tachycardias with regular ventricular activity (sinus tachycardia, atrioventricular node reentrant tachycardia, atrioventricular reentrant tachycardia, atrial flutter, atrial tachycardias)”
Cites
Principles and Practice of Infectious Diseases.
(1991) · Annals of Internal Medicine · doi:10.7326/0003-4819-114-9-818_5 · Cited by 12,045 · see citing works
A method for estimating the probability of adverse drug reactions
Naranjo, C. A., Busto, U., Sellers, E. M., Sandor, P., Ruiz, I., Roberts, E. A., Janecek, E., Domecq, C., & Greenblatt, D. J. (1981) · Clinical Pharmacology and Therapeutics · doi:10.1038/clpt.1981.154 · Cited by 11,914 · see citing works
Guidelines for the management of atrial fibrillation
Authors/Task Force Members, Camm, A. J., Kirchhof, P. F., Lip, G. Y. H., Schotten, U., Savelieva, I., Ernst, S., Gelder, I. C. V., Al‐Attar, N., Hindricks, G., et al. (2010) · European Heart Journal · doi:10.1093/eurheartj/ehq278 · Cited by 5,875 · see citing works
Self-citationHeart Disease: A Textbook of Cardiovascular Medicine.
(1984) · Annals of Internal Medicine · doi:10.7326/0003-4819-101-3-415_3 · Cited by 4,119 · see citing works
European guidelines on cardiovascular disease prevention in clinical practice: executive summary
Graham, I., Atar, D., Borch‐Johnsen, K., Boysen, G., Burell, G. K., Cífková, R., Dallongeville, J., Backer, G. D., Ebrahim, S. B. J., Gjelsvik, B., et al. (2007) · European Heart Journal · doi:10.1093/eurheartj/ehm316 · Cited by 3,840 · see citing works
Kushner (2021) · doi:10.12788/jfp · Cited by 3,799 · see citing works
ACC/AHA/HRS 2008 guidelines for device-based therapy of cardiac rhythm abnormalities
Epstein, A. E., DiMarco, J. P., Ellenbogen, K. A., Estes, N. A. M., Freedman, R. A., Gettes, L. S., Gillinov, A. M., Gregoratos, G., Hammill, S. C., Hayes, D. L., et al. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.02.032 · Cited by 2,546 · see citing works
Cardiac Electrophysiology: From Cell to Bedside
(1991) · Annals of Internal Medicine · doi:10.7326/0003-4819-114-12-1069_5 · Cited by 2,380 · see citing works
Rao, S. V., & Jollis, J. G. (2000) · Mayo Clinic Proceedings · doi:10.4065/75.10.991 · Cited by 2,230 · see citing works
Developed in collaboration with, European Heart Rhythm Association (EHRA), Heart Failure Association (HFA), and Heart Rhythm Society (HRS), societies, E. B. T. F., European Society of Emergency Medicine (EuSEM), European Federation of Internal Medicine (EFIM), European Union Geriatric Medicine Society (EUGMS), American Geriatrics Society (AGS), European Neurological Society (ENS), et al. (2009) · European Heart Journal · doi:10.1093/eurheartj/ehp298 · Cited by 2,040 · see citing works
Self-citationDrug-induced prolongation of the QT interval
Roden, D. M. (2004) · New England Journal of Medicine · doi:10.1056/nejmra032426 · Cited by 1,965 · see citing works
ACC/AHA/HRS 2008 Guidelines for Device-Based Therapy of Cardiac Rhythm Abnormalities
Epstein, A. E., Dimarco, J., Ellenbogen, K. A., Estes, N. A. M., Freedman, R. A., Gettes, L. S., Gillinov, A. M., Gregoratos, G., Hammill, S. C., Hayes, D. L., et al. (2008) · Circulation · doi:10.1161/circualtionaha.108.189742 · Cited by 1,768 · see citing works
Graham (2007) · doi:10.1097/01.hjr.0000277983.23934.c9 · Cited by 1,647 · see citing works
Sudden Cardiac Arrest Associated with Early Repolarization
Haïssaguerre, M., Derval, N., Sacher, F., Jesel, L., Deisenhofer, I., de Roy, L., Pasquié, J.-L., Nogami, A., Babuty, D., Yli-Mayry, S., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa071968 · Cited by 1,449 · see citing works
Self-citationZipes, D. P., Camm, A. J., Borggrefe, M., Buxton, A. E., Chaitman, B., Fromer, M., Gregoratos, G., Klein, G., Moss, A. J., Myerburg, R. J., et al. (2006) · Circulation · doi:10.1161/circulationaha.106.178233 · Cited by 1,080 · see citing works
Self-citationPelliccia, A. (2005) · European Heart Journal · doi:10.1093/eurheartj/ehi325 · Cited by 983 · see citing works
Drug induced QT prolongation and torsades de pointes
Yap, Y. G., & Camm, A. J. (2003) · Heart · doi:10.1136/heart.89.11.1363 · Cited by 958 · see citing works
Blomstrom-Lundqvist (2003) · doi:10.1161/01.cir.0000091380.04100.84 · Cited by 955 · see citing works
Self-citationGlotzer, T. V., Daoud, E. G., Wyse, D. G., Singer, D. E., Ezekowitz, M. D., Hilker, C., Miller, C., Qi, D., & Ziegler, P. D. (2009) · Circulation: Arrhythmia and Electrophysiology · doi:10.1161/circep.109.849638 · Cited by 879 · see citing works
Cardiovascular complications of cocaine use
Lange, R. A., & Hillis, L. D. (2001) · New England Journal of Medicine · doi:10.1056/nejm200108023450507 · Cited by 810 · see citing works
Long QT syndromes and torsade de pointes
Viskin, S. (1999) · The Lancet · doi:10.1016/s0140-6736(99)02107-8 · Cited by 690 · see citing works
Self-citationMapping and Ablation of Idiopathic Ventricular Fibrillation
Haı̈ssaguerre, M., Shoda, M., Jaı̈s, P., Nogami, A., Shah, D. C., Kautzner, J., Arentz, T., Kalusche, D., LAMAISON, D., Griffith, M., et al. (2002) · Circulation · doi:10.1161/01.cir.0000027564.55739.b1 · Cited by 683 · see citing works
Self-citationGuidelines on Management (diagnosis and treatment) of syncope ? update 2004
Brignole, M., Alboni, P., Benditt, D. G., Bergfeldt, L., Blanc, J., Thomsen, P. E. B., van Dijk, J. G., Fitzpatrick, A. P., Hohnloser, S. H., Janousek, J., et al. (2004) · EP Europace · doi:10.1016/j.eupc.2004.08.008 · Cited by 648 · see citing works
Self-citationJ-Point Elevation in Survivors of Primary Ventricular Fibrillation and Matched Control Subjects
Rosso, R., Kogan, E., Belhassen, B., Rozovski, U., Scheinman, M. M., Zeltser, D., Halkin, A., Steinvil, A., Heller, K., Glikson, M., et al. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.07.010 · Cited by 566 · see citing works
Self-citationGuidelines on management (diagnosis and treatment) of syncope-update 2004. Executive Summary.
Brignole, M., Alboni, P., Benditt, D. G., Bergfeldt, L., Blanc, J., Thomsen, P. E. B., van Dijk, J. G., Fitzpatrick, A. P., Hohnloser, S. H., Janoušek, J., et al. (2004) · European Heart Journal · doi:10.1016/j.ehj.2004.09.004 · Cited by 562 · see citing works
Self-citationPheochromocytoma: Diagnosis, Localization and Management
Bravo, E. L., & Gifford, R. W. (1984) · New England Journal of Medicine · doi:10.1056/nejm198411153112007 · Cited by 471 · see citing works
Krahn, A. D., Klein, G. J., Yee, R., & Skanes, A. C. (2001) · Circulation · doi:10.1161/01.cir.104.1.46 · Cited by 405 · see citing works
BOTTO, G. L., PADELETTI, L., SANTINI, M., CAPUCCI, A., GULIZIA, M., ZOLEZZI, F., FAVALE, S., MOLON, G., RICCI, R., BIFFI, M., et al. (2009) · Journal of Cardiovascular Electrophysiology · doi:10.1111/j.1540-8167.2008.01320.x · Cited by 380 · see citing works
Role of Purkinje conducting system in triggering of idiopathic ventricular fibrillation
Haı̈ssaguerre, M., Shah, D. C., Jaı̈s, P., Shoda, M., Kautzner, J., Arentz, T., Kalusche, D., Kadish, A. H., Griffith, M., Gaïta, F., et al. (2002) · The Lancet · doi:10.1016/s0140-6736(02)07807-8 · Cited by 380 · see citing works
Self-citationExcessive Supraventricular Ectopic Activity and Increased Risk of Atrial Fibrillation and Stroke
Binici, Z., Intzilakis, T., Nielsen, O. W., Køber, L., & Sajadieh, A. (2010) · Circulation · doi:10.1161/circulationaha.109.874982 · Cited by 379 · see citing works
Thyroid hormone and the cardiovascular system
Klein, I. (1990) · The American Journal of Medicine · doi:10.1016/0002-9343(90)90531-h · Cited by 370 · see citing works
The Prevalence of Symptoms in Medical Outpatients and the Adequacy of Therapy
Arrington, M. E. (1990) · Archives of Internal Medicine · doi:10.1001/archinte.1990.00040031685016 · Cited by 367 · see citing works
Indications for the use of diagnostic implantable and external ECG loop recorders
Task Force members, Brignole, M., Vardas, P., Hoffman, E., Huikuri, H., Moya, A., Ricci, R., Sulke, N., Wieling, W., EHRA Scientific Documents Committee, et al. (2009) · Europace · doi:10.1093/europace/eup097 · Cited by 362 · see citing works
Self-citationEmotional and physical precipitants of ventricular arrhythmia
Lampert, R., Joska, T., Burg, M. M., Batsford, W. P., McPherson, C. A., & Jain, D. (2002) · Circulation · doi:10.1161/01.cir.0000031733.51374.c1 · Cited by 347 · see citing works
Flaker, G. C., Belew, K., Beckman, K., Vidaillet, H., Kron, J., Safford, R., Mickel, M., & Barrell, P. (2005) · American Heart Journal · doi:10.1016/j.ahj.2004.06.032 · Cited by 341 · see citing works
Brignole, M., Menozzi, C., Bartoletti, A., Giada, F., Lagi, A., Ungar, A., Ponassi, I., Mussi, C., Maggi, R., Re, G., et al. (2006) · European Heart Journal · doi:10.1093/eurheartj/ehi647 · Cited by 332 · see citing works
Self-citationBethesda Conference #36 and the European Society of Cardiology Consensus Recommendations Revisited
Pelliccia, A., Zipes, D. P., & Maron, B. J. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.08.055 · Cited by 295 · see citing works
Kirchhof, P., Auricchio, A., Bax, J., Crijns, H., Camm, J., Diener, H.-C., Goette, A., Hindricks, G., Hohnloser, S., Kappenberger, L., et al. (2007) · Europace · doi:10.1093/europace/eum191 · Cited by 293 · see citing works
Self-citationLong-Term Outcome in Asymptomatic Men with Exercise-Induced Premature Ventricular Depolarizations
Jouven, X., Zureik, M., Desnos, M., Courbon, D., & Ducimetière, P. (2000) · New England Journal of Medicine · doi:10.1056/nejm200009213431201 · Cited by 288 · see citing works
Noda, T., Shimizu, W., Taguchi, A., Aiba, T., Satomi, K., Suyama, K., Kurita, T., Aihara, N., & Kamakura, S. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.05.077 · Cited by 283 · see citing works
Glucose counterregulation, hypoglycemia, and intensive insulin therapy in diabetes mellitus
Epstein, F. H., Cryer, P. E., & Gerich, J. E. (1985) · New England Journal of Medicine · doi:10.1056/nejm198507253130405 · Cited by 273 · see citing works
Short- and Long-Term Prognosis of Syncope, Risk Factors, and Role of Hospital Admission
Costantino, G., Perego, F., Dipaola, F., Borella, M., Galli, A., Cantoni, G., Dell’Orto, S., Dassi, S., Filardo, N., Duca, P. G., et al. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.08.059 · Cited by 246 · see citing works
Kinlay, S., Leitch, J. W., Neil, A., Chapman, B. L., Hardy, D. B., & Fletcher, P. J. (1996) · Annals of Internal Medicine · doi:10.7326/0003-4819-124-1_part_1-199601010-00003 · Cited by 245 · see citing works
Kadish, A. H., Buxton, A. E., Kennedy, H. L., Knight, B. P., Mason, J. W., Schuger, C. D., Tracy, C. M., Winters, W. L., Boone, A. W., Elnicki, M., et al. (2001) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(01)01680-1 · Cited by 244 · see citing works
Crawford, M. H., Bernstein, S. J., Deedwania, P. C., DiMarco, J. P., Ferrick, K. J., Garson, A., Green, L. A., Greene, H. L., Silka, M. J., Stone, P. H., et al. (1999) · Circulation · doi:10.1161/01.cir.100.8.886 · Cited by 215 · cited 3× · see citing works
“Indeed, ambulatory ECG monitoring utilizes electrocardiographic recorders that are able to monitor the patient’s cardiac rhythm for long periods of time or that can be activated by the patient when symptoms occur.(69,70) The devices currently used for ambulatory ECG monitoring can be subdivided into two main categorie…”
BackgroundEvaluation and outcomes of patients with palpitations
Weber, B. E., & Kapoor, W. N. (1996) · The American Journal of Medicine · doi:10.1016/s0002-9343(97)89451-x · Cited by 196 · see citing works
Brugada syndrome and fever: Genetic and molecular characterization of patients carrying mutations
Keller, D. I., Rougier, J., Kučera, J., et al. (2005) · Cardiovascular Research · doi:10.1016/j.cardiores.2005.03.024 · Cited by 195 · see citing works
ROTHMAN, S. A., LAUGHLIN, J. C., SELTZER, J., WALIA, J. S., BAMAN, R. I., SIOUFFI, S. Y., SANGRIGOLI, R. M., & KOWEY, P. R. (2007) · Journal of Cardiovascular Electrophysiology · doi:10.1111/j.1540-8167.2006.00729.x · Cited by 194 · see citing works
Raatikainen, M. J. P., Uusimaa, P., van Ginneken, M. M. E., Janssen, J. P. G., & Linnaluoto, M. (2008) · Europace · doi:10.1093/europace/eun203 · Cited by 189 · see citing works
Self-citationEaker, E. D., Sullivan, L. M., Kelly-Hayes, M., D’Agostino, R. B., & Benjamin, E. J. (2004) · Circulation · doi:10.1161/01.cir.0000118535.15205.8f · Cited by 184 · see citing works
Mitral valve prolapse: causes, clinical manifestations, and management
Devereux, R. B., Kramer-Fox, R., & Kligfield, P. (1989) · Annals of Internal Medicine · doi:10.7326/0003-4819-111-4-305 · Cited by 180 · see citing works
Use of ambulatory electrocardiographic (Holter) monitoring
DiMarco, J. P., & Philbrick, J. T. (1990) · Annals of Internal Medicine · doi:10.7326/0003-4819-113-1-53 · Cited by 177 · see citing works
Induced Brugada-Type Electrocardiogram, a Sign for Imminent Malignant Arrhythmias
Junttila, J. M., Gonzalez, M., Lizotte, É., et al. (2008) · Circulation · doi:10.1161/circulationaha.107.746495 · Cited by 173 · see citing works
Evaluation of patients with palpitations
Zimetbaum, P., & Josephson, M. E. (1998) · New England Journal of Medicine · doi:10.1056/nejm199805073381907 · Cited by 172 · see citing works
Leitch, J. W., Klein, G. J., Yee, R., Leather, R. A., & Kim, Y. H. (1992) · Circulation · doi:10.1161/01.cir.85.3.1064 · Cited by 171 · see citing works
Viskin, S., Rosso, R., Rogowski, O., & Belhassen, B. (2005) · Journal of Cardiovascular Electrophysiology · doi:10.1111/j.1540-8167.2005.50040.x · Cited by 171 · see citing works
Self-citationPregnancy and Cardiovascular Disease
Ueland, K. (1977) · Medical Clinics of North America · doi:10.1016/s0025-7125(16)31347-5 · Cited by 163 · see citing works
Recurrent Unexplained Palpitations (RUP) Study
Giada, F., Gulizia, M., Francese, M., Croci, F., Santangelo, L., Santomauro, M., Occhetta, E., Menozzi, C., & Raviele, A. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.02.036 · Cited by 158 · see citing works
Self-citationUnrecognized Paroxysmal Supraventricular Tachycardia: Potential for Misdiagnosis as Panic Disorder
Lessmeier, T. J. (1997) · Archives of Internal Medicine · doi:10.1001/archinte.1997.00440260085013 · Cited by 157 · see citing works
Mode of Onset of Malignant Ventricular Arrhythmias in Idiopathic Ventricular Fibrillation
Viskin, S., Lesh, M. D., Eldar, M., Fish, R., SETBON, I., Laniado, S., & Belhassen, B. (1997) · Journal of Cardiovascular Electrophysiology · doi:10.1111/j.1540-8167.1997.tb00997.x · Cited by 152 · see citing works
Self-citationKrahn, A. D., Klein, G. J., Yee, R., & Norris, C. (1998) · The American Journal of Cardiology · doi:10.1016/s0002-9149(98)00237-9 · Cited by 151 · see citing works
Acute emotional stress and cardiac arrhythmias
Ziegelstein, R. C. (2007) · JAMA · doi:10.1001/jama.298.3.324 · Cited by 146 · see citing works
The Evolving Role of Ambulatory Arrhythmia Monitoring in General Clinical Practice
Zimetbaum, P. J., & Josephson, M. E. (1999) · Annals of Internal Medicine · doi:10.7326/0003-4819-130-10-199905180-00020 · Cited by 139 · see citing works
Panic Disorder, Palpitations, and the Awareness of Cardiac Activity
BARSKY, A. J., CLEARY, P. D., SARNIE, M. K., & RUSKIN, J. N. (1994) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-199402000-00001 · Cited by 135 · cited 1× · see citing works
“When, after this history-taking, it becomes likely that palpitations are not related to arrhythmia but rather to psychosomatic disorders, before starting more extensive cardiovascular procedures, it is judicious to take the help of a mental health expert.(1,22,23,47,58)”
BackgroundZimetbaum, P. J., Kim, K. Y., Josephson, M. E., Goldberger, A. L., & Cohen, D. J. (1998) · Annals of Internal Medicine · doi:10.7326/0003-4819-128-11-199806010-00002 · Cited by 133 · see citing works
HOLMAN, E. (1965) · Circulation · doi:10.1161/01.cir.32.6.1001 · Cited by 120 · see citing works
Role of autonomic reflexes in syncope associated with paroxysmal atrial fibrillation
Brignole, M., Gianfranchi, L., Menozzi, C., Raviele, A., Oddone, D., Lolli, G., & Bottoni, N. (1993) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(93)90426-2 · Cited by 114 · see citing works
Self-citationGiant T–U Waves Precede Torsades de Pointes in Long QT Syndrome
Kirchhof, P., Franz, M. R., Bardai, A., & Wilde, A. M. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.03.043 · Cited by 112 · see citing works
Joshi, A. K., Kowey, P. R., Prystowsky, E. N., Benditt, D. G., Cannom, D. S., Pratt, C. M., McNamara, A., & Sangrigoli, R. M. (2005) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2004.12.015 · Cited by 110 · see citing works
Shimizu, W. (2009) · Heart Rhythm · doi:10.1016/j.hrthm.2009.06.017 · Cited by 104 · see citing works
Brown, A. P., Dawkins, K. D., & Davies, J. G. (1987) · Heart · doi:10.1136/hrt.58.3.251 · Cited by 96 · see citing works
Krahn, A. D., Klein, G. J., Yee, R., & Mandab, V. (1999) · American Heart Journal · doi:10.1016/s0002-8703(99)70411-4 · Cited by 95 · see citing works
González-Torrecilla, E., Almendral, J., Arenal, A., Atienza, F., Atea, L. F., del Castillo, S., & Fernández-Avilés, F. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.02.059 · Cited by 89 · see citing works
Keller, D. I., Huang, H., ZHAO, J., et al. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2006.02.030 · Cited by 86 · see citing works
Utility and cost of event recorders in the diagnosis of palpitations, presyncope, and syncope
Fogel, R. I., Evans, J. J., & Prystowsky, E. N. (1997) · The American Journal of Cardiology · doi:10.1016/s0002-9149(96)00717-5 · Cited by 83 · see citing works
Diagnostic approach to palpitations.
Abbott, A. V. (2005) · PubMed · Cited by 83 · see citing works
The Hemodynamic Mechanism of Pounding in the Neck in Atrioventricular Nodal Reentrant Tachycardia
Gürsoy, S., Steurer, G., Brugada, J., Andries, E., & Brugada, P. (1992) · New England Journal of Medicine · doi:10.1056/nejm199209103271105 · Cited by 83 · see citing works
Kaleschke, G., Hoffmann, B., Drewitz, I., Steinbeck, G., Naebauer, M., Goette, A., Breithardt, G., & Kirchhof, P. (2009) · Europace · doi:10.1093/europace/eup262 · Cited by 81 · see citing works
Self-citationChest pain, palpitations and panic
Mayou, R. (1998) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(97)00209-2 · Cited by 78 · see citing works
Utility of Patient-Activated Cardiac Event Recorders in General Clinical Practice
Zimetbaum, P., Kim, K. Y., Ho, K. K. L., Zebede, J., Josephson, M. E., & Goldberger, A. L. (1997) · The American Journal of Cardiology · doi:10.1016/s0002-9149(96)00766-7 · Cited by 77 · see citing works
Does this patient with palpitations have a cardiac arrhythmia?
Thavendiranathan, P. (2009) · JAMA · doi:10.1001/jama.2009.1673 · Cited by 75 · see citing works
Psychiatric disorders in medical outpatients complaining of palpitations
Barsky, A. J., Cleary, P. D., Coeytaux, R. R., & Ruskin, J. N. (1994) · Journal of General Internal Medicine · doi:10.1007/bf02599176 · Cited by 73 · see citing works
Value of history-taking in syncope patients: in whom to suspect long QT syndrome?
Colman, N., Bakker, A., Linzer, M., Reitsma, J. B., Wieling, W., & Wilde, A. A. M. (2009) · EP Europace · doi:10.1093/europace/eup101 · Cited by 73 · see citing works
Brugada, P., Andries, E., Gürsoy, S., & Brugada, J. (1993) · The Lancet · doi:10.1016/0140-6736(93)91155-f · Cited by 71 · see citing works
Panic disorder in cardiac outpatients
(1993) · American Journal of Psychiatry · doi:10.1176/ajp.150.5.780 · Cited by 71 · see citing works
Illicit drugs and cardiac arrhythmias in athletes
Furlanello, F., Serdoz, L. V., Cappato, R., & De Ambroggi, L. (2007) · European Journal of Cardiovascular Prevention & Rehabilitation · doi:10.1097/hjr.0b013e3280ecfe3e · Cited by 70 · see citing works
Ventricular ectopic activity: prevalence and risk
Messineo, F. C. (1989) · The American Journal of Cardiology · doi:10.1016/0002-9149(89)91200-9 · Cited by 64 · see citing works
Temperature modulation of ventricular arrhythmogenicity in a canine tissue model of Brugada syndrome
Morita, H., Zipes, D. P., Morita, S. T., & Wu, J. (2006) · Heart Rhythm · doi:10.1016/j.hrthm.2006.10.015 · Cited by 62 · see citing works
The clinical course of palpitations in medical outpatients
Barsky, A. J. (1995) · Archives of Internal Medicine · doi:10.1001/archinte.1995.00430160124012 · Cited by 61 · see citing works
Thomas, J. E., Schirger, A., Fealey, R. D., & Sheps, S. G. (1981) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(26)01416-3 · Cited by 61 · see citing works
OLSON, J. A., FOUTS, A. M., PADANILAM, B. J., & PRYSTOWSKY, E. N. (2007) · Journal of Cardiovascular Electrophysiology · doi:10.1111/j.1540-8167.2007.00779.x · Cited by 59 · see citing works
Characteristics of patients presenting to a cardiac clinic with palpitation
Mayou, R. (2003) · QJM · doi:10.1093/qjmed/hcg017 · Cited by 52 · see citing works
Tavazzi, L., Am, Z., & Rondanelli, R. (1986) · PubMed · Cited by 52 · see citing works
Fever as a Precipitant of Idiopathic Ventricular Fibrillation in Patients with Normal Hearts
Pasquié, J., Sanders, P., Hocini, M., et al. (2004) · Journal of Cardiovascular Electrophysiology · doi:10.1046/j.1540-8167.2004.04388.x · Cited by 49 · see citing works
Self-citationSummerton, N., Mann, S., Rigby, A., Petkar, S., & Dhawan, J. (2001) · Family Practice · doi:10.1093/fampra/18.4.383 · Cited by 49 · see citing works
Idiopathic Ventricular Fibrillation “Le Syndrome d'Haïssaguerre” and the Fear of J Waves
Viskin, S. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.11.011 · Cited by 47 · see citing works
Self-citationJeejeebhoy, F. M., Dorian, P., & Newman, D. M. (2000) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(99)00103-8 · Cited by 46 · cited 1× · see citing works
“When, after this history-taking, it becomes likely that palpitations are not related to arrhythmia but rather to psychosomatic disorders, before starting more extensive cardiovascular procedures, it is judicious to take the help of a mental health expert.(1,22,23,47,58)”
BackgroundScalvini, S., Zanelli, E., Martinelli, G., Baratti, D., Giordano, A., & Glisenti, F. (2005) · Journal of Telemedicine and Telecare · doi:10.1258/1357633054461930 · Cited by 45 · see citing works
Scherr, D., Dalal, D., Henrikson, C. A., Spragg, D. D., Berger, R. D., Calkins, H., & Cheng, A. (2008) · Journal of Interventional Cardiac Electrophysiology · doi:10.1007/s10840-008-9251-0 · Cited by 45 · see citing works
Brugada Syndrome Unmasked By Febrile Illness
Kum, L. C. C., FUNG, J. W. H., & Sanderson, J. E. (2002) · Pacing and Clinical Electrophysiology · doi:10.1046/j.1460-9592.2002.01660.x · Cited by 43 · see citing works
Palpitations and Cardiac Awareness After Heart Transplantation
BARSKY, A. J., Ahern, D. K., Brener, J. M., Surman, O. S., Ring, C., & DEC, G. W. (1998) · Psychosomatic Medicine · doi:10.1097/00006842-199809000-00007 · Cited by 41 · see citing works
Chapter 4 Sensory innervation of the heart
Malliani, A., Lombardi, F., & Pagani, M. (1986) · Progress in brain research · doi:10.1016/s0079-6123(08)62755-7 · Cited by 40 · see citing works
The Cardiologists’ Worst Nightmare
Viskin, S., & Antzelevitch, C. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.07.010 · Cited by 40 · see citing works
Self-citationGallego, A. M., Dı́az-Infante, E., & García‐Bolao, I. (2009) · Revista Española de Cardiología · doi:10.1016/s0300-8932(09)73080-5 · Cited by 40 · see citing works
Gallego, A. M., Dı́az-Infante, E., & García‐Bolao, I. (2009) · Revista Española de Cardiología (English Edition) · doi:10.1016/s1885-5857(09)73355-9 · Cited by 39 · see citing works
Arrhythmias and sport practice
Mont, L. (2010) · Heart · doi:10.1136/hrt.2008.160903 · Cited by 38 · see citing works
Self-citationHoefman, E., van Weert, H. C., Boer, K. R., Reitsma, J., Koster, R. W., & Bindels, P. J. (2006) · Family Practice · doi:10.1093/fampra/cml065 · Cited by 38 · see citing works
Transtelephonic electrocardiographic transmission for management of cardiac arrhythmias
Antman, E. M., Ludmer, P. L., McGowan, N., Bosak, M., Friedman, P. L., Alvarez, P., Then, V., & Nevins, D. (1986) · The American Journal of Cardiology · doi:10.1016/s0002-9149(86)80031-5 · Cited by 37 · see citing works
Coronary Angioplasty in Early Post-Infarction Angina
de Feyter, P. J., Serruys, P. W. J. C., van den Brand, M., et al. (1986) · European Heart Journal · doi:10.1093/eurheartj/7.suppl_c.99 · Cited by 37 · see citing works
Diabetes influences the cardiac symptoms related to atrial fibrillation
Sugishita, K., Shiono, E., Sugiyama, T., & Ashida, T. (2003) · Circulation Journal · doi:10.1253/circj.67.835 · Cited by 37 · see citing works
Reiffel, J. A., Schulhof, E., Joseph, B., Severance, E., Wyndus, P., & McNamara, A. (1991) · Journal of Electrocardiology · doi:10.1016/0022-0736(91)90007-9 · Cited by 36 · see citing works
Noninvasive Electrocardiology in Clinical Practice
Woodruff, A. (2001) · PubMed Central · Cited by 30 · see citing works
Utility of patient-activated cardiac event recorders in the detection of cardiac arrhythmias
Wu, C.-C., Hsieh, M.-H., Tai, C.-T., Chiang, C.-E., Yu, W.-C., Lin, Y.-K., Tsao, H.-M., Ding, P. Y.-A., & Chen, S.-A. (2003) · Journal of Interventional Cardiac Electrophysiology · doi:10.1023/a:1023604816368 · Cited by 27 · see citing works
The natural history of palpitations in a family practice.
Knudson, M. P. (1987) · PubMed · Cited by 25 · see citing works
Approach to the patient with palpitations
Weitz, H. H., & Weinstock, P. J. (1995) · Medical Clinics of North America · doi:10.1016/s0025-7125(16)30078-5 · Cited by 23 · see citing works
Cardiological guidelines for competitive sports eligibility.
Delise, P., Guiducci, U., Zeppilli, P., et al. (2005) · PubMed · Cited by 21 · see citing works
Self-citationHoefman, E., Boer, K. R., van Weert, H. C., Reitsma, J. B., Koster, R. W., & Bindels, P. J. (2007) · Family Practice · doi:10.1093/fampra/cmm056 · Cited by 20 · see citing works
Paisey, J. R., Yue, A. M., Treacher, K., Roberts, P. R., & Morgan, J. M. (2005) · International Journal of Cardiology · doi:10.1016/j.ijcard.2003.06.020 · Cited by 19 · see citing works
Brignole, M., & Shen, W. K. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.07.092 · Cited by 15 · see citing works
Diagnostic management of patients with palpitations of unknown origin.
Giada, F., & Raviele, A. (2004) · PubMed · Cited by 14 · see citing works
Self-citationNaccarelli, G. V. (2007) · Journal of Cardiovascular Electrophysiology · doi:10.1111/j.1540-8167.2006.00737.x · Cited by 13 · see citing works
Pharmacological testing in the diagnosis of arrhythmias.
Brembilla‐Perrot, B. (2010) · PubMed · Cited by 11 · see citing works
Coincidence of paroxysmal supraventricular tachycardia and panic disorder: two case reports
Domschke, K., Kirchhof, P., Zwanzger, P., Gerlach, A. L., Breithardt, G., & Deckert, J. (2010) · Annals of General Psychiatry · doi:10.1186/1744-859x-9-13 · Cited by 11 · see citing works
Self-citationDiagnosing the Mechanism of Supraventricular Tachycardia
Marchlinski, F. E. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.03.035 · Cited by 10 · see citing works
Differential diagnosis of palpitations. Preliminary development of a screening instrument
Barsky, A. J. (1997) · Archives of Family Medicine · doi:10.1001/archfami.6.3.241 · Cited by 10 · see citing works
Palpitations: a proper evaluation and approach to effective medical therapy
Pickett, C. C., & Zimetbaum, P. J. (2005) · Current Cardiology Reports · doi:10.1007/s11886-005-0090-7 · Cited by 9 · see citing works
Can patients discriminate between atrial fibrillation and regular supraventricular tachycardia?
Leitch, J. W., Klein, G. J., & Yee, R. (1991) · The American Journal of Cardiology · doi:10.1016/0002-9149(91)90420-p · Cited by 5 · see citing works
Behr, E. R., & Camm, A. J. (2008) · Circulation · doi:10.1161/circulationaha.108.786954 · Cited by 4 · see citing works
Porcupines: fine grained activity monitoring in psychiatry using accelerometer sensors
Laerhoven, K. V. (2010) · Annals of General Psychiatry · doi:10.1186/1744-859x-9-s1-s13 · Cited by 2 · see citing works
Flagged first, then by citations
Research works printed but not linked: 7
- Malliani, 1986, Sensory innervation of the heart, 39
- Braunwald, 1992, Valvular heart disease, 1007
- Rosenthal, 1992, Hematological–oncological disorders and heart disease, 1742
- Dinardello, 1990, Fever, 464
- Zipes, 1995, Assessment of patients with cardiac arrhythmia, 1009
- Waktare, 2001, Holter and event recordings for arrhythmia detection, 3
- Kirchhof, 2009, Giant T-U waves precede torsades de pointes in long QT syndrome, J Am Coll Cardiol, 54, 143, 10.1016/j.jacc.2009.03.043 · DOI · Paper page
Cited by
Sorted by citations
2014 ESC Guidelines on diagnosis and management of hypertrophic cardiomyopathy
Authors/Task Force members, Elliott, P. M., Anastasakis, A., Borger, M. A., Borggrefe, M., Cecchi, F., Charron, P., Hagege, A. A., Lafont, A., Limongelli, G., et al. (2014) · European Heart Journal · doi:10.1093/eurheartj/ehu284 · Cited by 4,332 · see citing works
Self-citation2014 ESC Guidelines on diagnosis and management of hypertrophic cardiomyopathy
Elliot, P. M., Anastasakis, A., Borger, M. A., Borggrefe, M., Cecchi, F., Charron, P., Hagège, A. A., Lafont, A. M., Limongelli, G., Mahrholdt, H., et al. (2014) · Kardiologia Polska · doi:10.5603/kp.2014.0212 · Cited by 342 · see citing works
Self-citationSteinberg, J. S., Varma, N., Cygankiewicz, I., Aziz, P., Balsam, P., Baranchuk, A., Cantillon, D. J., Dilaveris, P., Dubner, S. J., El-Sherif, N., et al. (2017) · Heart Rhythm · doi:10.1016/j.hrthm.2017.03.038 · Cited by 303 · see citing works
“Clinical presentation and frequency of palpitations should be taken into consideration when selecting the device (Crawford et al., 1999; Mittal, 2015; Raviele et al., 2011).”
MethodAn Expert Consensus Document on the Management of Cardiovascular Manifestations of Fabry Disease
Linhart, A., Germain, D. P., Olivotto, I., Akhtar, M. M., Anastasakis, A., Hughes, D. A., Namdar, M., Pieroni, M., Hagège, A. A., Cecchi, F., et al. (2020) · European Journal of Heart Failure · doi:10.1002/ejhf.1960 · Cited by 233 · see citing works
A study of implanted cardiac rhythm recorders in advanced cardiac AL amyloidosis
Sayed, R. H., Rogers, D. P. S., Khan, F. Z., Wechalekar, A. D., Lachmann, H. J., Fontana, M., Mahmood, S., Sachchithanantham, S., Patel, K. P., Hawkins, P. N., et al. (2014) · European Heart Journal · doi:10.1093/eurheartj/ehu506 · Cited by 166 · see citing works
2023 HRS expert consensus statement on the management of arrhythmias during pregnancy
Joglar, J. A., Kapa, S., Saarel, E. V., Dubin, A. M., Görenek, B., Hameed, A. B., de Melo, S. L., Leal, M. A., Mondesert, B. A., Pacheco, L. D., et al. (2023) · Heart Rhythm · doi:10.1016/j.hrthm.2023.05.017 · Cited by 165 · see citing works
Steinberg, J. S., Varma, N., Cygankiewicz, I., Aziz, P. F., Balsam, P., Baranchuk, A. M., Cantillon, D. J., Dilaveris, P., Dubner, S., El‐Sherif, N., et al. (2017) · Annals of Noninvasive Electrocardiology · doi:10.1111/anec.12447 · Cited by 118 · see citing works
“Clinical presentation and frequency of palpitations should be taken into consideration when selecting the device (Crawford et al., 1999; Mittal, 2015; Raviele et al., 2011).”
MethodArnar, D. O., Mairesse, G. H., Boriani, G., Calkins, H. G., Chin, A., Coats, A. J. S., Deharo, J., Svendsen, J. H., Heidbüchel, H., Isa, R., et al. (2019) · EP Europace · doi:10.1093/europace/euz046 · Cited by 120 · see citing works
Steeds, R. P., Garbi, M., Cardim, N. M., Kasprzak, J. D., Sade, L. E., Nihoyannopoulos, P., Popescu, B. A., Stefanidis, A. S., Cosyns, B., Monaghan, M. J., et al. (2016) · European Heart Journal - Cardiovascular Imaging · doi:10.1093/ehjci/jew333 · Cited by 101 · see citing works
“Syncope and palpitations are among the most common symptoms leading to medical presentation and the role of TTE is to rule out structural cardiac disease where there is a clinical suspicion on examination or following a 12-lead ECG.(44,45) A normal TTE in this setting is an important finding that helps to direct the c…”
BackgroundLocati, E. T., Moya, A., Oliveira, M., Tanner, H., Willems, R., Lunati, M., & Brignole, M. (2016) · Europace · doi:10.1093/europace/euv311 · Cited by 95 · see citing works
Hendrikx, T., Rosenqvist, M., Wester, P. O., Sandström, H., & Hörnsten, R. (2014) · BMC Cardiovascular Disorders · doi:10.1186/1471-2261-14-41 · Cited by 73 · see citing works
“Other studies investigating palpitations looking at a general population show quite similar characteristics for age, sex and comorbidity [1,10,27,28].”
BackgroundHimmelreich, J. C. L., Karregat, E. P. M., Lucassen, W. A. M., van Weert, H. C. P. M., de Groot, J. R., Handoko, M. L., Nijveldt, R., & Harskamp, R. E. (2019) · The Annals of Family Medicine · doi:10.1370/afm.2438 · Cited by 71 · see citing works
Reed, M. J., Grubb, N. R., Lang, C. C., O'Brien, R., Simpson, K., Padarenga, M., Grant, A., Tuck, S., Keating, L., Coffey, F., et al. (2019) · EClinicalMedicine · doi:10.1016/j.eclinm.2019.02.005 · Cited by 57 · see citing works
Locati, E. H., Vecchi, A. M., Vargiu, S., Cattafi, G., & Lunati, M. (2013) · EP Europace · doi:10.1093/europace/eut337 · Cited by 54 · see citing works
2020 Clinical practice guidelines for Hypertrophic cardiomyopathy
Габрусенко, С. А., Gudkova, A. Y., Koziolova, N. A., Alexandrova, S. А., Berseneva, M., Гордеев, М. Л., Sl, D., Zaklyazminskaya, E. V., Irtyuga, O. B., Kaplunova, V. Y., et al. (2021) · Russian Journal of Cardiology · doi:10.15829/1560-4071-2021-4541 · Cited by 46 · see citing works
Probst, M. A., Mower, W. R., Kanzaria, H. K., Hoffman, J. R., Buch, E. F., & Sun, B. C. (2014) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2014.02.020 · Cited by 43 · see citing works
Implantable loop recorders in the real world: a study of two Canadian centers
Ibrahim, O., Drew, D., Hayes, C. J., McIntyre, W. F., Seifer, C. M., Hopman, W. M., Glover, B. M., & Baranchuk, A. M. (2017) · Journal of Interventional Cardiac Electrophysiology · doi:10.1007/s10840-017-0294-y · Cited by 34 · see citing works
“Current ESC guidelines suggest the use of ILRs in patients with infrequent, severe, and potentially sinister palpitations unexplained by other investigations, when patients are nonadherent to other diagnostic strategies, or when clinically significant arrhythmia must be ruled out [8, 16].”
BackgroundExercise and Arrhythmias: A Double‐Edged Sword
Manolis, A. S., & MANOLIS, A. A. (2016) · Pacing and Clinical Electrophysiology · doi:10.1111/pace.12879 · Cited by 27 · see citing works
Sciaraffia, E., Chen, J., Hocini, M., Larsen, T. B., Potpara, T., & Blomstrom-Lundqvist, C. (2014) · Europace · doi:10.1093/europace/euu222 · Cited by 33 · see citing works
Self-citationHung, K., Lee, C. C., & Choy, S. (2015) · Springer series in bio-/neuroinformatics · doi:10.1007/978-3-319-12817-7_15 · Cited by 24 · see citing works
“after each monitoring session), so timely detection and prediction of abnormality cannot be effectively achieved [10].”
BackgroundHimmelreich, J. C. L., & Harskamp, R. E. (2023) · Cardiovascular Digital Health Journal · doi:10.1016/j.cvdhj.2023.03.002 · Cited by 24 · see citing works
Cardiac monitoring for patients with palpitations
Pascual, J. F., Romero, J. C., Pérez‐Rodon, J., Benito, B., Santos‐Ortega, A., Maldonado, J., González, I. F., & Rivas‐Gándara, N. (2021) · World Journal of Cardiology · doi:10.4330/wjc.v13.i11.608 · Cited by 23 · see citing works
Relationship Between Palpitation and Mental Health
Alijaniha, F., Noorbala, A.-A., Afsharypuor, S., Naseri, M., Fallahi, F., Mosaddegh, M., Zadeh, S. F., & Sadrai, S. (2015) · Iranian Red Crescent Medical Journal · doi:10.5812/ircmj.22615 · Cited by 22 · see citing works
“Despite its high prevalence, in many cases, the diagnostic and therapeutic management of this symptom proved to be poorly efficacious and lead to permanent distress and disability in patients and continual recourse to healthcare facilities (7).”
BackgroundClinical Approach to Patients with Palpitations
Giada, F., & Raviele, A. (2018) · Cardiac Electrophysiology Clinics · doi:10.1016/j.ccep.2018.02.010 · Cited by 21 · see citing works
Self-citationPlacidi, S., Drago, F., Milioni, M., et al. (2016) · Pacing and Clinical Electrophysiology · doi:10.1111/pace.12866 · Cited by 21 · see citing works
Evidence-Based Approach to Palpitations
Weinstock, C., Wagner, H., Snuckel, M., & Katz, M. (2020) · Medical Clinics of North America · doi:10.1016/j.mcna.2020.09.004 · Cited by 19 · see citing works
“9,21,22 Based on the relative cost of bloodwork compared with other diagnostic modalities (see Box 4 ), this remains a relatively cost-efficient starting point for the workup of palpitations.”
Reed, M. J., Grubb, N. R., Lang, C. C., O’Brien, R., Simpson, K., Padarenga, M., Grant, A., & Tuck, S. (2018) · Trials · doi:10.1186/s13063-018-3098-1 · Cited by 17 · see citing works
Review of menopausal palpitations measures
Sheng, Y., Carpenter, J. S., Elomba, C. D., Alwine, J. S., Yue, M., Pike, C. A., Chen, C. X., & Tisdale, J. E. (2021) · Women s Midlife Health · doi:10.1186/s40695-021-00063-6 · Cited by 17 · see citing works
“In the general population, palpitations (1) account for 16% of general physicians’ visits [9], (2) are the second leading reason for cardiologist visits [9], and (3) are related to increased risk for cardiac arrythmias when they affect sleep and work [10].”
BackgroundBenefits of an early management of palpitations
Clémenty, N., Fourquet, A., André, C., Bisson, A., Pierre, B., Fauchier, L., Babuty, D., & Angoulvant, D. (2018) · Medicine · doi:10.1097/md.0000000000011466 · Cited by 17 · see citing works
External Cardiac Loop Recorders: Functionalities, Diagnostic Efficacy, Challenges and Opportunities
Rajanna, R. R., Sriraam, N., Prakash, V. S. R., Vittal, P. R., Arun, U., & Sahoo, S. (2021) · IEEE Reviews in Biomedical Engineering · doi:10.1109/rbme.2021.3055219 · Cited by 17 · see citing works
Palpitations: Evaluation and management by primary care practitioners
Govender, I., Nashed, K. K., Rangiah, S., Okeke, S. O., & Maphasha, O. M. (2022) · South African Family Practice · doi:10.4102/safp.v64i1.5449 · Cited by 17 · see citing works
Karregat, E. P. M., Himmelreich, J. C. L., Lucassen, W. A. M., Busschers, W. B., van Weert, H. C. P. M., & Harskamp, R. E. (2020) · Family Practice · doi:10.1093/fampra/cmaa076 · Cited by 17 · see citing works
Managing athletes with palpitations of unknown origin with an external loop recorder: A cohort study
SCIARRA, L., CAVARRETTA, E., SICILIANI, S., SETTE, A., SCARÀ, A., GRIECO, D., DE RUVO, E., PALAMÀ, Z., NESTI, M., ROMANO, S., et al. (2022) · The Journal of Sports Medicine and Physical Fitness · doi:10.23736/s0022-4707.21.12831-2 · Cited by 15 · see citing works
Carrington, M., Providencia, R. A., Chahal, C. A. A., Ricci, F., Epstein, A. E., Gallina, S., Fedorowski, A., Sutton, R., & Khanji, M. Y. (2022) · EP Europace · doi:10.1093/europace/euac088 · Cited by 15 · see citing works
Efficacy And Safety Of Implantable Loop Recorder: Experience Of A Center.
Silveira, I., Sousa, M. J., Antunes, N., Silva, V. M. D. S., Roque, C., Pinheiro‐Vieira, A., Lagarto, V., Hipólito-Reis, A., Luz, A., & Torres, S. (2016) · Europe PMC (PubMed Central) · doi:10.4022/jafib.1425 · Cited by 15 · see citing works
Schoormans, D., van de Poll-Franse, L. V., Vissers, P. A. J., van Herk‐Sukel, M. P. P., Pedersen, S. S., Rottmann, N., Horsbøl, T. A., Dalton, S. O., & Denollet, J. (2017) · Breast Cancer Research and Treatment · doi:10.1007/s10549-017-4387-1 · Cited by 14 · see citing works
“…use was used as a proxy for both anxiety and CVD, we cannot rule out that the association may partly be explained by a pharmacokinetic interaction between both drug types, although little is known about this association and the usage of anxiolytics is common among CVD populations [31, 32].”
Correlates of palpitations during menopause: A scoping review
Carpenter, J. S., Sheng, Y., Pike, C. A., Elomba, C. D., Alwine, J. S., Chen, C. X., & Tisdale, J. E. (2022) · Women s Health · doi:10.1177/17455057221112267 · Cited by 13 · see citing works
“Title contains word palpitations47,58 2 (2) Region Africa36,88,103 3 (4) Asia, East50,51,60,65,73,76,93,105,113–116 12 (14) Asia, North58,67,74,86,94,100 6 (7) Asia, South41,52,54,70,85,91,92,111 8 (10) Asia, South East34,90,102,106,107 5 (6) Australia64,89 2 (2) Europe, Continental39,63,71,72,81,96,101 7 (8) Europe,…”
Probst, M. A., Kanzaria, H. K., Hoffman, J. R., Mower, W. R., Moheimani, R. S., Sun, B., & Quigley, D. D. (2015) · Journal of Emergency Medicine · doi:10.1016/j.jemermed.2015.02.013 · Cited by 12 · see citing works
“There is only one clinical guideline pertaining to the management of palpitations, published by the European Heart Rhythm Association, which does not specifically discuss EDmanagement (6).”
BackgroundThe Role of Sleep Disturbance, Depression and Anxiety in Frail Patients with AF–Gender Differences
Jankowska‐Polańska, B., Polański, J., Dudek, K. D., Sławuta, A., Mazur, G. J., & Gajek, J. J. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm10010011 · Cited by 12 · see citing works
“acutely experienced by women, slim individuals and persons lying on the left side [25,26].”
BackgroundNewham, W. G., & Tayebjee, M. H. (2017) · Journal of Atrial Fibrillation · doi:10.4022/jafib.1514 · Cited by 12 · see citing works
“In such patients, ambulatory ECG (AECG) monitors are commonly utilized.[1]-[3] Recently a new AECG device has been developed which allows the user to record a single lead ECG on their smartphone.”
BackgroundClinical Presentation of Sustained Monomorphic Ventricular Tachycardia Without Cardiac Arrest
Havakuk, O., Viskin, D., Viskin, S., Adler, A., Rozenbaum, Z., Zuzut, M. E., Borohovitz, A., Chorin, E., & Rosso, R. (2020) · Journal of the American Heart Association · doi:10.1161/jaha.120.016673 · Cited by 12 · see citing works
Self-citationAttanasio, P., Huemer, M., Loehr, L., Parwani, A. S., Boldt, L., Haverkamp, W., & Wutzler, A. (2015) · Annals of Noninvasive Electrocardiology · doi:10.1111/anec.12301 · Cited by 11 · see citing works
Pascual, J. F., Santos‐Ortega, A., Roca‐Luque, I., Rivas‐Gándara, N., Pérez‐Rodon, J., Milà, L., David Garcia-dorado, A., & Moya‐Mitjans, À. (2018) · Revista Española de Cardiología (English Edition) · doi:10.1016/j.rec.2018.04.007 · Cited by 12 · see citing works
Pascual, J. F., Santos‐Ortega, A., Roca‐Luque, I., Rivas‐Gándara, N., Pérez‐Rodon, J., Milà, L., David Garcia-dorado, A., & Moya‐Mitjans, À. (2018) · Revista Española de Cardiología · doi:10.1016/j.recesp.2018.04.013 · Cited by 9 · see citing works
Elliot, P. M., Anastasakis, A., Borger, M. A., Borggrefe, M., Cecchi, F., Charron, P., Hagège, A. A., Lafont, A. M., Limongelli, G., Mahrholdt, H., et al. (2014) · Revista Española de Cardiología · doi:10.1016/j.recesp.2014.12.001 · Cited by 10 · see citing works
Self-citationBobbo, M., Amoroso, S., Tamaro, G., et al. (2018) · Acta Paediatrica · doi:10.1111/apa.14486 · Cited by 9 · see citing works
McLellan, A. J. A., & Kalman, J. M. (2019) · Australian Journal of General Practice · doi:10.31128/ajgp-12-17-4436 · Cited by 9 · see citing works
Carpenter, J. S., Cortés, Y. I., Tisdale, J. E., Sheng, Y., Jackson, E. A., Barinas‐Mitchell, E., & Thurston, R. C. (2022) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0000000000002082 · Cited by 9 · see citing works
Diagnosis and management of phantom tachycardias based on an electrophysiologically guided approach
Tsiachris, D., Koutagiar, I. P., Gatzoulis, K. A., Αρσένος, Π., Rigatou, A., Dilaveris, P., Sideris, S. K., Papadopoulos, A., Kritikos, A., Stefanadis, C., et al. (2016) · Hellenic Journal of Cardiology · doi:10.1016/j.hjc.2016.11.030 · Cited by 9 · see citing works
“Therefore, ILR use is restricted in selected patients with severe and infrequent palpitations (inter-symptom interval 4 weeks) and when all other modalities are ineffective.(2,12) Interestingly, in our study population only 16% of EPS evaluations were negative.”
BackgroundMethodInfluentialSalam, A. M., Gersh, B. J., Albinali, H., Singh, R., Asaad, N., Al‐Qahtani, A., & Suwaidi, J. M. S. A. (2013) · International Journal of Clinical Practice · doi:10.1111/ijcp.12230 · Cited by 8 · see citing works
Carnlöf, C., Schenck-Gustafsson, K. G., Jensen‐Urstad, M., & Insulander, P. (2021) · European Journal of Cardiovascular Nursing · doi:10.1093/eurjcn/zvaa031 · Cited by 9 · see citing works
Arrhythmias in Pediatric Age: A Narrative Review
Strangio, A., Ielapi, J., Sabatino, J., Sarro, R. D., Costanzo, A. D., Sportelli, M., Sicilia, F., Panuccio, G., Salerno, N., Sorrentino, S., et al. (2025) · Children · doi:10.3390/children12121580 · Cited by 7 · see citing works
Palpitations in the Cancer Patient
Essa, H., & Lip, G. Y. H. (2021) · European Cardiology Review · doi:10.15420/ecr.2021.44 · Cited by 7 · see citing works
Karregat, E. P. M., Vooijs, P., Wierda, E., Harskamp, R. E., Lucassen, W. A. M., Himmelreich, J. C. L., & van Charante, E. P. M. (2025) · BMJ Open · doi:10.1136/bmjopen-2025-101557 · Cited by 6 · see citing works
Vikhe, R., Masure, S., Das, M. K., et al. (2025) · ACS Applied Electronic Materials · doi:10.1021/acsaelm.4c02263 · Cited by 6 · see citing works
Freund, O., Caspi, I., Alcalay, I., Brezis, M. R., Frydman, S., & Bornstein, G. (2023) · Scientific Reports · doi:10.1038/s41598-023-39803-1 · Cited by 6 · see citing works
Diagnosing symptomatic arrhythmia via mobile phone
Richley, D., & Graham, A. (2015) · British Journal of Cardiac Nursing · doi:10.12968/bjca.2015.10.3.130 · Cited by 6 · see citing works
CURRENT METHODS OF AMBULATORY ELECTROCARDIOGRAM MONITORING. TECHNICAL ASPECTS
Pervova, E. V. (2017) · The Clinician · doi:10.17650/1818-8338-2016-10-4-16-28 · Cited by 6 · see citing works
Emergency Management of Palpitations in the Elderly
Jamshed, N., Dubin, J. S., & ELDADAH, Z. A. (2012) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2012.10.003 · Cited by 6 · see citing works
Vicent, L., Rosillo, N., Moreno, G., Bodes, R. S., Goñi, C., Sobrino, J. L. B., Seara, G., & Bueno, H. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1202960 · Cited by 5 · see citing works
“Frontiers in Cardiovascular Medicine 05 general practitioner (15% of primary care visits) (24, 25) and the main reason for referral in younger women, whereas it was much less common in men.”
BackgroundDhillon, R. (2018) · Paediatrics and Child Health · doi:10.1016/j.paed.2018.10.009 · Cited by 5 · see citing works
A decade of insertable cardiac monitors with remote monitoring in pediatric patients
Silvetti, M. S., Tamburri, I., Porco, L., Saputo, F. A., Mambro, C. D., Righi, D., Cazzoli, I., Cicenia, M., Campisi, M., Ravà, L., et al. (2022) · Reviews in Cardiovascular Medicine · doi:10.31083/j.rcm2301027 · Cited by 6 · see citing works
“A positive diagnosis was made in few patients and was mainly due to atrio-ventricular node reentry tachycardia, which should be considered in case of suspicious symptoms and when other examinations, including EPS, proved inconclusive [17].”
BackgroundCullen, J., Reed, M. J., Muir, A., Murphy, R., Pollard, V., Zangana, G. A. S., Krupej, S., Askham, S., Holdsworth, P., & Davies, L. (2021) · European Journal of Emergency Medicine · doi:10.1097/mej.0000000000000859 · Cited by 4 · see citing works
“This health monitoring revolution [1] will allow better diagnosis of acute medical events such as palpitation, responsible for 300,000 presentations to UK Emergency Departments (ED) per year, and 16% of attendances to General/Family practice [2].”
BackgroundWever, W. D., Gruwez, H., Dhont, S., Pison, L., Vandervoort, P. M., & Haemers, P. (2025) · European Heart Journal Acute Cardiovascular Care · doi:10.1093/ehjacc/zuaf060 · Cited by 4 · see citing works
Pallikadavath, S., Patel, R., Sarania, R., Ahmad, T., Vali, Z., Kandala, N.-B., & Sandilands, A. (2020) · Family Practice · doi:10.1093/fampra/cmaa094 · Cited by 5 · see citing works
Management of atrial fibrillation and anticoagulant therapies
O'Neill, M. D., Whitaker, J., Birns, J., & Wright, M. J. (2017) · doi:10.1093/med/9780198701590.003.0103 · Cited by 4 · see citing works
“Quick flutter skip”: midlife women's descriptions of palpitations
Carpenter, J. S., Fagan, R., Alzahrani, M. A., Jaynes, H. A., Tisdale, J. E., Kovacs, R. J., Chen, C. X., & Draucker, C. B. (2023) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0000000000002244 · Cited by 4 · see citing works
Abdelfattah, R. S., & Froelicher, V. F. (2015) · Current Sports Medicine Reports · doi:10.1097/01.csmr.0000466789.13643.f1 · Cited by 4 · see citing works
Management of palpitations and cardiac arrhythmias in pregnancy
Roberts, A., Mechery, J., Mechery, A., Clarke, B., & Vause, S. (2019) · The Obstetrician & Gynaecologist · doi:10.1111/tog.12599 · Cited by 4 · see citing works
Reed, M. J., Muir, A., Cullen, J., Murphy, R., Pollard, V., Zangana, G., Krupej, S., Askham, S., Holdsworth, P., & Davies, L. (2021) · Medicina · doi:10.3390/medicina57020147 · Cited by 4 · see citing works
“Patients with palpitations and pre-syncope commonly present to emergency departments (EDs), accounting for 300,000 ED presentations a year in the United Kingdom [1,2] and being one of the commonest presentations to general and family practice (16% of presentations) [3].”
BackgroundAşkın, A., Güvendi, E., Özkan, A., Şimşek, E. Ç., Kocabaş, U., & Tosun, A. (2017) · Acta Medica (Hradec Kralove Czech Republic) · doi:10.14712/18059694.2018.10 · Cited by 3 · see citing works
Kamiński, M., Borger, M., & Bogdański, P. (2021) · International Journal of Angiology · doi:10.1055/s-0041-1735203 · Cited by 4 · see citing works
“26 The palpitations may occur incidentally, and for this reason, people with minor ailments may not disclose the symptom.”
BackgroundGender and Age Differences in the Evaluation and Clinical Outcomes of Patients with Palpitations
Jeong, S. Y., Chen, A., Wu, Y., & Lee, M. S. (2024) · Journal of General Internal Medicine · doi:10.1007/s11606-024-08860-1 · Cited by 3 · see citing works
“4,13 20 We hypothesized that among patients presenting in the outpatient clinic with palpitations, women would be less likely to undergo diagnostic testing compared to men and that testing may be associated with better outcomes.”
InfluentialAbordaje de las palpitaciones y la taquicardia
Mateo-Martínez, A., Villegas-García, M., & Sánchez‐Martínez, M. (2015) · FMC - Formación Médica Continuada en Atención Primaria · doi:10.1016/j.fmc.2015.03.002 · Cited by 3 · see citing works
Babwah, T., Ramcharan, C., Ramgoolam, C., Sookoo, N., Cresse, W., Pamassar, M., Kassie, P., & Ramdin, R. (2018) · Journal of Caffeine and Adenosine Research · doi:10.1089/caff.2017.0008 · Cited by 3 · see citing works
Experience in the use of wireless system “Spyder” for multi-day monitoring of electrocardiogram
Sokolskaya, M. A., Shvartz, V. A., & Bockeria, O. L. (2018) · Annaly aritmologii · doi:10.15275/annaritmol.2018.4.3 · Cited by 3 · see citing works
“Поскольку, во-первых, стандартное ХМ – это средняя длительность записи ЭКГ 24–48 ч (1–2 сут), во-вторых, многосуточное ХМ имеет низкий комплаенс из-за дискомфорта, который вызывают многочисленные провода, в связи с чем пациенты преждевременно прерывают исследование самостоятельно [6, 7].”
Vega, J. M. G., Puerto, F. S. P., & Mora-Vicente, G. (2021) · Arqueología de la Arquitectura · doi:10.3989/arq.arqt.2021.004 · Cited by 3 · see citing works
Enfoque semiológico de las palpitaciones
Gaviria, M. Á., Bustos, C. H., & Mora, G. (2014) · Revista de la Facultad de Medicina · doi:10.15446/revfacmed.v62n1.43779 · Cited by 3 · see citing works
Mospan, D., Mospan, V., Fomovskaya, E., Yurko, A., & Artemenko, V. O. (2019) · Transactions of Kremenchuk Mykhailo Ostrohradskyi National University · doi:10.30929/1995-0519.2019.6.167-172 · Cited by 3 · see citing works
Türe, M., Akın, A., Özbek, M., Ertaş, K., Balkam, A. F., Uç, D., İlter, S., Ergin, E., Arslan, G. Y., & Baysal, E. (2025) · Cardiology in the Young · doi:10.1017/s1047951125110007 · Cited by 2 · see citing works
Evans, W. R. H., Akyea, R. K., Weng, S. F., et al. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12081290 · Cited by 2 · see citing works
High Diagnostic Accuracy of Long-Term Electrocardiogram Interpretation by General Practitioners
Jortveit, J., Boskovic, M., Sandberg, E. L., Vegsundvåg, J., & Halvorsen, S. (2024) · International Journal of Telemedicine and Applications · doi:10.1155/2024/6624344 · Cited by 2 · see citing works
“Many patients visit their GPs due to symptoms that may be caused by cardiac arrhythmias [17, 18].”
BackgroundNwafor, C. E., & Agbamoro, J. (2024) · Asian Journal of Medicine and Health · doi:10.9734/ajmah/2024/v22i61018 · Cited by 2 · see citing works
Assessment of palpitations in patients with frequent premature ventricular contractions
Gao, Y., Jiang, R., Liu, Y., Li, Z., Xu, X., Li, S.-J., Li, X.-J., & Han, B. (2024) · Cardiovascular Electrophysiology · doi:10.1111/jce.16476 · Cited by 1 · see citing works
Review: Rapid assessment of patients with palpitations
Laksono, S., & Kusharsamita, H. (2023) · Family Medicine & Primary Care Review · doi:10.5114/fmpcr.2023.130098 · Cited by 1 · see citing works
Albertsen, N., Jensen, M. M., Hansen, K. L. K., Pedersen, M. L., Andersen, S., Brock, C., & Riahi, S. (2024) · CJC Open · doi:10.1016/j.cjco.2024.03.011 · Cited by 1 · see citing works
“35 However, the prevalence of most comorbidities that predispose patients to AF are at the same level among our study population, compared to that among the general population in Greenland.”
ResultClinical consequences of smartwatch implementation in a cardiology outpatient clinic
Petersen, C. S., Olesen, J. B., Nielsen, S. K., Jensen, M. H., Al‐Alak, A., Risom, S. S., Holt, A., Hamawand, D., Hansen, R. B., Hansen, M. L., et al. (2025) · Danish Medical Journal · doi:10.61409/a12240906 · Cited by 1 · see citing works
Esmailian, A., & Alasti, M. (2026) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2026.1832643 · Cited by 1 · see citing works
“Contemporary clinical cohorts further demonstrate substantial healthcare utilization, particularly in patients with recurrent arrythmia burden or coexisting structural or genetic heart disease substrates (4 – 8).”
77/m mit Palpitationen und Schwindel
Pereira, J. F. M. (2023) · Zeitschrift für Allgemeinmedizin · doi:10.1007/s44266-023-00063-x · Cited by 1 · see citing works
Karregat, E. P. M., de Koning, M. A., Himmelreich, J. C. L., et al. (2024) · Primary Health Care Research & Development · doi:10.1017/s1463423624000057 · Cited by 1 · see citing works
“An important arrhythmia that can be missed when obtaining an ECG at a later time is atrial fibrillation (AF), which can occur in a paroxysmal form (Raviele et al ., 2011; Hindricks et al ., 2020).”
BackgroundApproach to palpitations in primary care
Chua, C. E., Leungsuwan, S., Ng, L. Y., & Teo, D. B. S. (2024) · Singapore Medical Journal · doi:10.4103/singaporemedj.smj-2021-417 · Cited by 1 · see citing works
“[9,12] Cardiac dysrhythmias, such as vagal nerve‑mediated ventricular premature contraction, can also occur at rest.”
BackgroundInfluentialA pilot survey of breast cancer survivors’ reporting of palpitations to healthcare providers
Carpenter, J. S., Sheng, Y., Snyder, M., Fagan, R., Ekanayake, V., & Elkins, G. R. (2024) · Women s Health · doi:10.1177/17455057241305077 · Cited by 1 · see citing works
Management of Palpitations in Urgent Care
Barkoduah, E., & Collins, J. P. (2012) · Cited by 1 · see citing works
CURRENT METHODS OF OUTPATIENT ELECTROCARDIOGRAPHIC MONITORING. CLINICAL ASPECTS
Pervova, E. V. (2017) · The Clinician · doi:10.17650/1818-8338-2017-11-2-58-73 · Cited by 1 · see citing works
Recognising and treating arrhythmias in primary care
Richley, D. (2019) · Practice Nursing · doi:10.12968/pnur.2019.30.6.270 · Cited by 1 · see citing works
External Loop Recorders: Primary Care Placement Is Noninferior to Hospital-Based Cardiac Unit
Callum, K., Hall, L., Jack, S., et al. (2020) · Journal of Primary Care & Community Health · doi:10.1177/2150132720946147 · Cited by 1 · see citing works
Uribe-Vergara, J., Briceño, I., Martínez, J., et al. (2020) · Archivos de cardiología de México · doi:10.24875/acm.19000268 · Cited by 1 · see citing works
The arrhythmic risk in Kearns–Sayre syndrome: still many questions unanswered—Authors’ reply
Mambro, C. D., Tamborrino, P. P., & Drago, F. (2021) · EP Europace · doi:10.1093/europace/euab105 · Cited by 1 · see citing works
Health care centre and emergency department utilization by patients with episodes of tachycardia
Nordblom, A.-K., Boysen, G. N., Berglund, M., & Kjellsdotter, A. (2022) · BMC Cardiovascular Disorders · doi:10.1186/s12872-022-02568-y · Cited by 1 · see citing works
“Previous research has shown a negative effect on patients’ daily lives [6, 14–16] and patient frustration due to repeated, time-consuming visits to health care services and increased utility of health care resources [3, 6, 14].”
BackgroundInfluentialStaloch, D. A., & Chami, M. E. (2020) · Springer eBooks · doi:10.1007/978-3-030-47868-1_25 · Cited by 1 · see citing works
- Authors
- Raviele, A., Giada, F., Bergfeldt, L., Blanc, J. J., Blomstrom-Lundqvist, C., Mont, L., Morgan, J. M., Raatikainen, M. J. P., Steinbeck, G., Viskin, S., reviewers, D., Kirchhof, P., Braunschweig, F., Borggrefe, M., Hocini, M., Bella, P. D., & Shah, D. C.
- Affiliations
- Ospedale dell' Angelo (IT)
- PF Calvi Hospital 2 Cardiovascular Department , , Noale-Venice ,
- Sahlgrenska University Hospital (SE)
- Bretagne University 4 Cardiology Department , , Brest ,
- Uppsala University Hospital 5 Cardiology Department , , Uppsala ,
- Hospital Clinic 6 Cardiology Department , , , Barcelona ,
- University Hospital Southampton NHS Foundation Trust (GB)
- Tampere University Hospital (FI)
- Ludwig-Maximilians-Universität München (DE)
- Tel Aviv University (IL)
- University Hospital Münster (DE)
- Karolinska University Hospital (SE)
- Hôpital Cardiologique du Haut-Lévêque (FR)
- Pessac 14 Hopital du Haut Leveque , ,
- Ospedale San Raffaele 15 , Milan ,
- 16 Cantonal Hospital, Geneva, Switzerland
- ORCID
- Venue
- Europace
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-01-01
- Volume
- 13
- Issue
- 7
- Pages
- 920-934
- ISSN
- 1099-5129 (ISSN-L)
- 1532-2092
- OpenAlex
- W1989735748
- Semantic Scholar
- 25b0a796effed62d415c4ba59d5f0a2363603639
- Cited by
- 149
- References
- 127
- Citations by year
- 2026: 11 · 2025: 13 · 2024: 9 · 2023: 10 · 2022: 10 · 2021: 19 · 2020: 12 · 2019: 8 · 2018: 11 · 2017: 11 · 2016: 8 · 2015: 9 · 2014: 9 · 2013: 3 · 2012: 6
- FWCI
- 3.96
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- EP Europace (publishedVersion)
- PubMed (publishedVersion)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Arrhythmias and Treatments
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
- Keywords
- palpitations, arrhythmia diagnosis, diagnostic workup, clinical evaluation, gatekeeper function, symptom management, quality of life, health care utilization, syncope
- MeSH terms
- Arrhythmias, Cardiac, Electrocardiography, Europe, Heart Diseases, Heart Rate, Humans, Prognosis, Psychophysiologic Disorders, Substance-Related Disorders
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Claims read by deepseek-v4.1-flash under definition version 3 (extract-v3) on 2026-10-09.
Classified by jev-1.13-20260917 (gold-guideline-v0.2) on 2026-10-09.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review