The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Recurrent Venous Thromboembolism in Patients with a Partial Deficiency of Protein S
Abstract
Protein S is an antithrombotic plasma protein that serves as a cofactor for another plasma protein, activated protein C. Protein S is required for the expression of the anticoagulant effect of activated protein C, which inhibits blood clotting at the levels of factors V and VIII in the blood-clotting cascade. We postulated that patients deficient in protein S would have inadequate regulatory control of the clotting cascade and would be prone to thrombotic disease in a manner similar to that of patients congenitally deficient in protein C. To determine whether protein S deficiency is associated with recurrent thrombosis, we developed a functional assay for the plasma protein. With this assay, the protein S activity of normal persons ranges from 63 to 160 per cent. Using this test, we have now identified six unrelated persons with severe recurrent venous thrombosis who were deficient in protein S, with levels between 15 and 37 per cent while they were not receiving warfarin therapy. Our data suggest that the determination of protein S levels will be useful in the evaluation of patients with recurrent thrombosis.
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Citations
Cites
Deficiency of protein C in congenital thrombotic disease.
Griffin, J. H., Evatt, B., Zimmerman, T. S., Kleiss, A. J., & Wideman, C. (1981) · Journal of Clinical Investigation · doi:10.1172/jci110385 · Cited by 1,250
Inherited Antithrombin Deficiency Causing Thrombophilia
Egeberg, O. (1965) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1656297 · Cited by 1,030
Familial protein S deficiency is associated with recurrent thrombosis.
Comp, P. C., Nixon, R. R., Cooper, M. R., & Esmon, C. T. (1984) · Journal of Clinical Investigation · doi:10.1172/jci111632 · Cited by 594
Self-citationDi Scipio, R. G., Hermodson, M. A., Yates, S. G., & Davie, E. W. (1977) · Biochemistry · doi:10.1021/bi00623a022 · Cited by 579
Walker, F. J., Sexton, P. W., & Esmon, C. T. (1979) · Biochimica et Biophysica Acta (BBA) - Enzymology · doi:10.1016/0005-2744(79)90103-7 · Cited by 475
Self-citationRegulation of activated protein C by a new protein. A possible function for bovine protein S.
Walker, F. J. (1980) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)70660-7 · Cited by 470
Regulation of activated protein C by protein S. The role of phospholipid in factor Va inactivation.
Walker, F. J. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)68566-2 · Cited by 391
Fulcher, C., Gardiner, J., Griffin, J., & Zimmerman, T. (1984) · Blood · doi:10.1182/blood.v63.2.486.486 · Cited by 301
A functional assay of protein C in human plasma
Sala, N., Owen, W., & Collen, D. (1984) · Blood · doi:10.1182/blood.v63.3.671.671 · Cited by 113
Cited by
Heijboer, H., Brandjes, D. P. M., Büller, H. R., Sturk, A., & ten Cate, J. W. (1990) · New England Journal of Medicine · doi:10.1056/nejm199011293232202 · Cited by 445
Kemmeren, J. M., Algra, A., Meijers, J. C. M., Tans, G., Bouma, B. N., Curvers, J., Rosing, J., & Grobbee, D. E. (2004) · Blood · doi:10.1182/blood-2003-04-1285 · Cited by 157
van Dam, S., Cordeiro, R., Craig, T., van Dam, J., Wood, S. H., & de Magalhães, J. P. (2012) · BMC Genomics · doi:10.1186/1471-2164-13-535 · Cited by 72
Adams, M., Fell, J., & Williams, A. (2009) · The Physician and Sportsmedicine · doi:10.3810/psm.2009.12.1750 · Cited by 9
Metadata
- Authors
- Comp, P. C., & Esmon, C. T.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1984-12-13
- Volume
- 311
- Issue
- 24
- Pages
- 1525-1528
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2077999696
- Cited by
- 508
- References
- 9
- FWCI
- 11.57
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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