The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Regulation of activated protein C by a new protein. A possible function for bovine protein S.
Open accessAbstract
The rate of inactivation of activated Factor V (Factor Va) by activated protein C can be enhanced by the addition of plasma. Plasma alone, however, had no effect upon Factor Va activity. This observation indicated that plasma may contain a cofactor for activated protein C. The cofactor activity was removed from plasma by barium citrate absorption and was eluted from the barium pellet. The cofactor activity eluted slightly ahead of prothrombin when chromatographed on quaternary aminoethyl (QAE)-Sephadex. The activity appeared to co-chromatograph with a protein that has been designated protein S. Purified cofactor-protein S had no effect upon the activity of purified bovine Factor Va either in the presence or in the absence of phospholipid. Purified cofactor-protein S caused a large enhancement in the rate of inactivation of Factor Va by activated protein C in the presence of phospholipid. These results indicate that protein S may be a cofactor for activated protein C.
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Cites
A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION
Bligh, E. G., & Dyer, W. J. (1959) · Canadian Journal of Biochemistry and Physiology · doi:10.1139/o59-099 · Cited by 54,751
Cited by
Isolation of a membrane-bound cofactor for thrombin-catalyzed activation of protein C.
Esmon, N. L., Owen, W. G., & Esmon, C. T. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)68276-1 · Cited by 699
Recurrent Venous Thromboembolism in Patients with a Partial Deficiency of Protein S
Comp, P. C., & Esmon, C. T. (1984) · New England Journal of Medicine · doi:10.1056/nejm198412133112401 · Cited by 508
Anderson, H. A., Maylock, C. A., Williams, J. A., Paweletz, C. P., Shu, H., & Shacter, E. (2003) · Nature Immunology · doi:10.1038/ni871 · Cited by 406
Pharmacodynamics of combined estrogen-progestin oral contraceptives: Effects on metabolism
Bastianelli, C., Farris, M., Rosato, E., Brosens, I., & Benagiano, G. (2016) · Expert Review of Clinical Pharmacology · doi:10.1080/17512433.2017.1271708 · Cited by 50
Metadata
- Authors
- Walker, F. J.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1980-06
- Volume
- 255
- Issue
- 12
- Pages
- 5521-5524
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1578912075
- Cited by
- 470
- References
- 1
- FWCI
- 3.97
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Walker, F. J. (1980). Regulation of activated protein C by a new protein. A possible function for bovine protein S. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(19)70660-7
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
