The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Active Myocarditis in the Spectrum of Acute Dilated Cardiomyopathies: Clinical Features, Histologic Correlates, and Clinical Outcome
Abstract
We studied the clinical features and course (average follow-up time, 18 months) of 27 patients with acute dilated cardiomyopathy (symptoms for less than 6 months) who were referred for endomyocardial biopsy. Almost 40 per cent of the patients subsequently had a rise in left ventricular ejection fraction (on average, from 0.21 to 0.41) and substantial improvement in heart failure; the remainder died or had chronic dilated cardiomyopathy. Biopsy revealed myocarditis in 18 patients, and this finding was especially common (89 per cent) in patients who had been ill for less than four weeks. But the biopsy specimen was negative in four patients whose clinical features and later course were diagnostic of myocarditis. Nine patients received immunosuppressive drugs, and four improved--a rate that did not differ from the rate of spontaneous improvement. Neither the histologic features of the biopsy specimen nor the clinical features at presentation were clearly correlated with subsequent improvement, whether or not immunosuppressive drugs were given. We conclude that many cases of unexplained dilated cardiomyopathy result from myocarditis. Definitive histologic confirmation depends on the duration of illness. The efficacy of immunosuppressive treatment must still be established.
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Citations
Cites
The natural history of idiopathic dilated cardiomyopathy
Fuster, V., Gersh, B. J., Giuliani, E. R., Tajik, A. J., Brandenburg, R. O., & Frye, R. L. (1981) · The American Journal of Cardiology · doi:10.1016/0002-9149(81)90534-8 · Cited by 943
Diagnosis and Classification of Myocarditis by Endomyocardial Biopsy
Fenoglio, J. J., Ursell, P. C., Kellogg, C. F., Drusin, R. E., & Weiss, M. B. (1983) · New England Journal of Medicine · doi:10.1056/nejm198301063080103 · Cited by 344
Dilated Cardiomyopathies of the Adult
Johnson, R. A., & Palacios, I. (1982) · New England Journal of Medicine · doi:10.1056/nejm198210213071704 · Cited by 314
Self-citationTreatment of acute inflammatory myocarditis assisted by endomyocardial biopsy
Mason, J. W., Billingham, M. E., & Ricci, D. R. (1980) · The American Journal of Cardiology · doi:10.1016/0002-9149(80)90174-5 · Cited by 293
Techniques for right and left ventricular endomyocardial biopsy
Mason, J. W. (1978) · The American Journal of Cardiology · doi:10.1016/0002-9149(78)90729-4 · Cited by 232
Coxsackie B myopericarditis in adults
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ADULT HEART DISEASE DUE TO THE COXSACKIE VIRUS B INFECTION
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Gallium-67 imaging in patients with dilated cardiomyopathy and biopsy-proven myocarditis.
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Cited by
A Clinical Trial of Immunosuppressive Therapy for Myocarditis
Mason, J. W., O'Connell, J. B., Herskowitz, A., Rose, N. R., McManus, B. M., Billingham, M. E., & Moon, T. E. (1995) · New England Journal of Medicine · doi:10.1056/nejm199508033330501 · Cited by 1,274
Cooper, L. T., Baughman, K. L., Feldman, A. M., Frustaci, A., Jessup, M., Kuhl, U., Levine, G. N., Narula, J., Starling, R. C., Towbin, J., et al. (2007) · Circulation · doi:10.1161/circulationaha.107.186093 · Cited by 1,030
Idiopathic Dilated Cardiomyopathy
Dec, G. W., & Fuster, V. (1994) · New England Journal of Medicine · doi:10.1056/nejm199412083312307 · Cited by 963
Self-citationFeldman, A. M., & McNamara, D. (2000) · New England Journal of Medicine · doi:10.1056/nejm200011093431908 · Cited by 958
Presentation, Patterns of Myocardial Damage, and Clinical Course of Viral Myocarditis
Mahrholdt, H., Wagner, A., Deluigi, C. C., Kispert, E., Hager, S., Meinhardt, G., Vogelsberg, H., Fritz, P., Dippon, J., Bock, C. T., et al. (2006) · Circulation · doi:10.1161/circulationaha.105.606509 · Cited by 869
Metadata
- Authors
- Dec, G. W., Palacios, I. F., Fallon, J. T., Aretz, H. T., Mills, J., Lee, D. C.-S., & Johnson, R. A.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1985-04-04
- Volume
- 312
- Issue
- 14
- Pages
- 885-890
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2053359234
- Cited by
- 566
- References
- 10
- FWCI
- 16.06
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Active Myocarditis in the Spectrum of Acute Dilated Cardiomyopathies: Clinical Features, Histologic Correlates, and Clinical Outcome. https://app.cochat.ai/papers/10.1056/nejm198504043121404
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- Dec, G. W., Palacios, I. F., Fallon, J. T., Aretz, H. T., Mills, J., Lee, D. C.-S., & Johnson, R. A. (1985). Active Myocarditis in the Spectrum of Acute Dilated Cardiomyopathies: Clinical Features, Histologic Correlates, and Clinical Outcome. New England Journal of Medicine. https://doi.org/10.1056/nejm198504043121404
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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