The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Reduction of Plasma Lipids, Lipoproteins, and Apoproteins by Dietary Fish Oils in Patients with Hypertriglyceridemia
Abstract
Dietary fish oils, which are rich in omega-3 fatty acids, have been reported to reduce plasma lipid levels in normolipidemic subjects. We examined the effects of fish oil in 20 hypertriglyceridemic patients: 10 with Type IIb hyperlipidemia and 10 with Type V. These patients were put on three diets differing primarily in fatty acid composition and fat content. The control diet contained a fatty acid mixture typical of a low-fat therapeutic diet (ratio of polyunsaturated to saturated fat, 1.4), the fish-oil diet contained omega-3 fatty acids, and the vegetable-oil diet was rich in the omega-6 fatty acid, linoleic acid. Each diet was followed for four weeks. In the Type IIb group, the fish-oil diet led to decreases in both plasma cholesterol (-27 per cent) and triglyceride (-64 per cent), as compared with the control diet. Very-low-density lipoproteins (VLDLs) were also reduced markedly. The vegetable-oil diet had much less effect. With fish oil, the Type V group had marked decreases in total cholesterol and triglyceride levels (-45 and -79 per cent, respectively). VLDL levels were dramatically lowered, as were apoprotein E levels. The vegetable-oil diet (unlike the fish-oil diet) produced a rapid and significant rise in plasma triglyceride levels. We conclude that fish oils and fish may be useful components of diets for the treatment of hypertriglyceridemia.
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Cites
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EICOSAPENTAENOIC ACID AND PREVENTION OF THROMBOSIS AND ATHEROSCLEROSIS?
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HÆMOSTATIC FUNCTION AND PLATELET POLYUNSATURATED FATTY ACIDS IN ESKIMOS
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The Composition of Food Consumed by Greenland Eskimos
Bang, H. O., Dyerberg, J., & Hjørne, N. (1976) · Acta Medica Scandinavica · doi:10.1111/j.0954-6820.1976.tb08198.x · Cited by 944
Fatty acid composition of the plasma lipids in Greenland Eskimos
Dyerberg, J., Bang, H., & Hjørne, N. (1975) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/28.9.958 · Cited by 877
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Self-citationDietary omega-3 fatty acid deficiency and visual loss in infant rhesus monkeys.
Neuringer, M., Connor, W. E., Van Petten, C., & Barstad, L. (1984) · Journal of Clinical Investigation · doi:10.1172/jci111202 · Cited by 645
Self-citationSuppression by diets rich in fish oil of very low density lipoprotein production in man.
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Self-citationPLASMA LIPIDS AND LIPOPROTEINS IN GREENLANDIC WEST COAST ESKIMOS
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Cited by
Omega-3 fatty acids in health and disease and in growth and development.
Simopoulos, A. (1991) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/54.3.438 · Cited by 2,162
Endres, S., Ghorbani, R., Kelley, V. E., Georgilis, K., Lonnemann, G., van der Meer, J. W. M., Cannon, J. G., Rogers, T. S., Klempner, M. S., Weber, P. C., et al. (1989) · New England Journal of Medicine · doi:10.1056/nejm198902023200501 · Cited by 1,910
Common variants at 30 loci contribute to polygenic dyslipidemia
Kathiresan, S., Willer, C. J., Peloso, G. M., Demissie, S., Musunuru, K., Schadt, E. E., Kaplan, L., Bennett, D., Li, Y., Tanaka, T., et al. (2009) · Nature Genetics · doi:10.1038/ng.291 · Cited by 1,364
Franz, M. J., Bantle, J. P., Beebe, C. A., Brunzell, J. D., Chiasson, J.-L., Garg, A., Holzmeister, L. A., Hoogwerf, B., Mayer-Davis, E., Mooradian, A. D., et al. (2002) · Diabetes Care · doi:10.2337/diacare.25.1.148 · Cited by 1,165
Fish oils and plasma lipid and lipoprotein metabolism in humans: a critical review
Harris, W. S. (1989) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38310-3 · Cited by 1,127
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Metadata
- Authors
- Phillipson, B. E., Rothrock, D. W., Connor, W. E., Harris, W. S., & Illingworth, D. R.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1985-05-09
- Volume
- 312
- Issue
- 19
- Pages
- 1210-1216
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2018815974
- Cited by
- 847
- References
- 18
- FWCI
- 73.72
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Reduction of Plasma Lipids, Lipoproteins, and Apoproteins by Dietary Fish Oils in Patients with Hypertriglyceridemia. https://app.cochat.ai/papers/10.1056/nejm198505093121902
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- Phillipson, B. E., Rothrock, D. W., Connor, W. E., Harris, W. S., & Illingworth, D. R. (1985). Reduction of Plasma Lipids, Lipoproteins, and Apoproteins by Dietary Fish Oils in Patients with Hypertriglyceridemia. New England Journal of Medicine. https://doi.org/10.1056/nejm198505093121902
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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