The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Changes in plasma lipids and lipoproteins during isotretinoin therapy for acne.
Abstract
Abnormalities in plasma lipids are a recognized side effect of isotretinoin therapy for nodulocystic acne. We studied 60 patients during 20 weeks of isotretinoin therapy, to measure changes in plasma lipids and lipoproteins, to compare plasma lipid responses in men and women, and to determine whether there are alterations in levels of lipoprotein lipase or hepatic triglyceride lipase that could explain the development of isotretinoin-induced hypertriglyceridemia. Mean triglyceride levels rose in men and women, with maximum mean increases of 46.3 mg per deciliter (P less than 0.0001) and 52.3 mg per deciliter (P less than 0.002), respectively. The maximum level was reached by 4 weeks of therapy in men but not until the 12th week in women. Nine of 53 patients (17 per cent) completing 20 weeks of isotretinoin therapy acquired hypertriglyceridemia, with values of 200 to 600 mg per deciliter. Both men and women had significant increases in mean plasma levels of cholesterol and low-density-lipoprotein cholesterol and decreases in mean levels of high-density-lipoprotein cholesterol. There were no significant changes in mean levels of lipoprotein lipase or hepatic triglyceride lipase. Plasma lipid and lipoprotein levels returned to base line by eight weeks after discontinuation of the drug. If sustained over a long period, the change in the ratio of low-density-lipoprotein cholesterol to high-density-lipoprotein cholesterol that we observed, from 2.4 to 3.0 (P less than 0.0001), would predict an increased risk of cardiovascular disease.
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“An increase in hepatic VLDL and apoC-III production and perhaps a decrease in LpL leading to increased triglyceride levels are also seen during use of retinoids such as isotretinoin and the anticancer drug bexarotene (110 -112).”
From Evaluation and Treatment of Hypertriglyceridemia: An Endocrine Society Clinical Practice Guideline (2012) · cites this paper as [110]
Citations
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Cited by
Sorted by citations
Guidelines of care for the management of acne vulgaris
Zaenglein, A. L., Pathy, A. L., Schlosser, B. J., Alikhan, A., Baldwin, H. E., Berson, D. S., Bowe, W. P., Graber, E. M., Harper, J. C., Kang, S., et al. (2016) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2015.12.037 · Cited by 1,597
Evaluation and Treatment of Hypertriglyceridemia: An Endocrine Society Clinical Practice Guideline
Berglund, L., Brunzell, J. D., Goldberg, A. C., Goldberg, I. J., Sacks, F., Murad, M. H., & Stalenhoef, A. F. H. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-3213 · Cited by 887
Drug-Induced Acute Pancreatitis: An Evidence-Based Review
Badalov, N. L., Baradarian, R., Iswara, K., Li, J., Steinberg, W. M., & Tenner, S. M. (2007) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2006.11.023 · Cited by 587
Guidelines of care for acne vulgaris management
Strauss, J. S., Krowchuk, D. P., Leyden, J. J., Lucky, A. W., Shalita, A. R., Siegfried, E. C., Thiboutot, D. M., Voorhees, A. S. V., Beutner, K. A., Sieck, C. K., et al. (2007) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2006.08.048 · Cited by 552
Issues in Hyperlipidemic Pancreatitis
Yadav, D. K., & Pitchumoni, C. S. (2003) · Journal of Clinical Gastroenterology · doi:10.1097/00004836-200301000-00016 · Cited by 435
Metadata
- Authors
- Bershad, S., Rubinstein, A., Paterniti, J. R., Le, N.-A., Poliak, S. C., Heller, B., Ginsberg, H. N., Fleischmajer, R., & Brown, W. V.
- Affiliations
- Mount Sinai Health System (US)
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1985-10-17
- Volume
- 313
- Issue
- 16
- Pages
- 981-985
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2338210778
- Cited by
- 217
- References
- 24
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2023: 6 · 2022: 9 · 2021: 4 · 2020: 5 · 2019: 3 · 2018: 2 · 2017: 5 · 2016: 6 · 2015: 6 · 2014: 4 · 2013: 9 · 2012: 12
- FWCI
- 12.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Acne and Rosacea Treatments and Effects
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Keywords
- isotretinoin, acne, hypertriglyceridemia, plasma lipids, lipoproteins, triglycerides, cholesterol, LDL cholesterol, HDL cholesterol, lipoprotein lipase, hepatic lipase, sex differences, cardiovascular risk, adverse drug reactions
- MeSH terms
- Acne Vulgaris, Adolescent, Adult, Cholesterol, Female, Humans, Lipase, Lipids, Lipoprotein Lipase, Lipoproteins, Cholesterol, HDL, Cholesterol, LDL, Male, Tretinoin, Triglycerides, Isotretinoin
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