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Cited by 718

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A New Chlamydia psittaci Strain, TWAR, Isolated in Acute Respiratory Tract Infections

Grayston, J. Thomas, Kuo, Cho-chou, Wang, San-pin, Altman, Jeff·1986·New England Journal of Medicine

Abstract

During a 2 1/2-year period, we studied 386 University of Washington students with acute respiratory disease, to determine whether a Chlamydia psittaci strain, here designated TWAR, is an important respiratory pathogen. Serologic evidence of recent TWAR infection was found in 13 students, and the organism was isolated from 8 of these. TWAR infection occurred in 12 percent of the students who had pneumonia (9 of 76), 5 percent of those with bronchitis (3 of 63), and 1 percent of those with pharyngitis (1 of 150). The TWAR infections occurred throughout the study period. Pharyngitis, often accompanied by laryngitis, was a common first symptom. Clinically, the infections resembled those with Myco-plasma pneumoniae; therefore, the patients were given courses of erythromycin used for the treatment of M. pneumoniae infections. This therapy proved to be inadequate. The limited data available suggest that the TWAR strain is a "human" C. psittaci that is spread from human to human, without a bird or animal host.

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Metadata

Authors
Grayston, J. T., Kuo, C.-C., Wang, S.-P., & Altman, J.
Venue
New England Journal of Medicine
Published
1986-07-17
Volume
315
Issue
3
Pages
161-168
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
OpenAlex
W2324373154
Cited by
718
References
0
FWCI
33.18
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: A New Chlamydia psittaci Strain, TWAR, Isolated in Acute Respiratory Tract Infections. https://app.cochat.ai/papers/10.1056/nejm198607173150305
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Grayston, J. T., Kuo, C.-C., Wang, S.-P., & Altman, J. (1986). A New Chlamydia psittaci Strain, TWAR, Isolated in Acute Respiratory Tract Infections. New England Journal of Medicine. https://doi.org/10.1056/nejm198607173150305

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.