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A New Chlamydia psittaci Strain, TWAR, Isolated in Acute Respiratory Tract Infections
Abstract
During a 2 1/2-year period, we studied 386 University of Washington students with acute respiratory disease, to determine whether a Chlamydia psittaci strain, here designated TWAR, is an important respiratory pathogen. Serologic evidence of recent TWAR infection was found in 13 students, and the organism was isolated from 8 of these. TWAR infection occurred in 12 percent of the students who had pneumonia (9 of 76), 5 percent of those with bronchitis (3 of 63), and 1 percent of those with pharyngitis (1 of 150). The TWAR infections occurred throughout the study period. Pharyngitis, often accompanied by laryngitis, was a common first symptom. Clinically, the infections resembled those with Myco-plasma pneumoniae; therefore, the patients were given courses of erythromycin used for the treatment of M. pneumoniae infections. This therapy proved to be inadequate. The limited data available suggest that the TWAR strain is a "human" C. psittaci that is spread from human to human, without a bird or animal host.
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Cited by
Niederman, M. S., Bass, J. B., Campbell, G. D., Fein, A. M., Grossman, R. F., Mandell, L. A., Marrie, T. J., Sarosi, G. A., Torres, A., & Yu, V. L. (1993) · American Review of Respiratory Disease · doi:10.1164/ajrccm/148.5.1418 · Cited by 1,045
Kuo, C. C., Jackson, L. A., Campbell, L. A., & Grayston, J. T. (1995) · Clinical Microbiology Reviews · doi:10.1128/cmr.8.4.451 · Cited by 819
Self-citationAcute respiratory illness in the community: frequency of illness and the agents involved
Monto, A. S., & Sullivan, K. M. (1993) · Epidemiology and Infection · doi:10.1017/s0950268800050779 · Cited by 458
Lieberman, D., Schlaeffer, F., Boldur, I., Lieberman, D., Horowitz, S., Friedman, M. G., Leiononen, M., Horovitz, O., Manor, E., & Porath, A. (1996) · Thorax · doi:10.1136/thx.51.2.179 · Cited by 353
Persistent Infection with Chlamydia pneumoniae following Acute Respiratory Illness
Hammerschlag, M. R., Chirgwin, K., Roblin, P. M., Gelling, M., Dumornay, W., Mandel, L., Smith, P., & Schachter, J. (1992) · Clinical Infectious Diseases · doi:10.1093/clinids/14.1.178 · Cited by 315
Metadata
- Authors
- Grayston, J. T., Kuo, C.-C., Wang, S.-P., & Altman, J.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1986-07-17
- Volume
- 315
- Issue
- 3
- Pages
- 161-168
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2324373154
- Cited by
- 718
- References
- 0
- FWCI
- 33.18
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Grayston, J. T., Kuo, C.-C., Wang, S.-P., & Altman, J. (1986). A New Chlamydia psittaci Strain, TWAR, Isolated in Acute Respiratory Tract Infections. New England Journal of Medicine. https://doi.org/10.1056/nejm198607173150305
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.