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Barrett's Esophagus
Abstract
BARRETT'S esophagus is a condition in which the squamous mucosa that normally lines the distal esophagus is replaced by a columnar epithelium resembling that in the stomach and intestines. This aberrant epithelium may be the site of esophageal ulceration, stricture, and adenocarcinoma. Early misconceptions and ongoing controversies regarding the definition, pathogenesis, and clinical features of Barrett's esophagus have resulted in persistent confusion about the disorder. Recent studies have clarified some of these issues substantially. The purpose of this report is to review critically some of the controversies about Barrett's esophagus and to describe the recent advances in our understanding of . . .
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Citations
Cited by
Koufman, J. A. (1991) · The Laryngoscope · doi:10.1002/lary.1991.101.s53.1 · Cited by 1,647
Overholt, B. F., Lightdale, C. J., Wang, K. K., Canto, M. I., Burdick, S., Haggitt, R. C., Bronner, M. P., Taylor, S. L., Grace, M. G. A., & Depot, M. (2005) · Gastrointestinal Endoscopy · doi:10.1016/j.gie.2005.06.047 · Cited by 527
Prevalence of columnar-lined (Barrett's) esophagus
Cameron, A. J., Zinsmeister, A. R., Ballard, D. J., & Carney, J. A. (1990) · Gastroenterology · doi:10.1016/0016-5085(90)90607-3 · Cited by 522
Duodenogastroesophageal reflux: Relationship to pH and importance in Barrett's esophagus
Champion, G., Richter, J. E., Vaezi, M. F., Singh, S., & Alexander, R. (1994) · Gastroenterology · doi:10.1016/0016-5085(94)90123-6 · Cited by 455
Amir, I., Konikoff, F. M., Oppenheim, M., Gophna, U., & Half, E. E. (2014) · Environmental Microbiology · doi:10.1111/1462-2920.12285 · Cited by 176
Metadata
- Authors
- Spechler, S. J., & Goyal, R. K.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1986-08-07
- Volume
- 315
- Issue
- 6
- Pages
- 362-371
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W4231986221
- Cited by
- 660
- References
- 0
- FWCI
- 28.14
- Type
- journal article
- Language
- en
- Open access
- closed
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How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
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- CoChat. (2026). Citation check: Barrett's Esophagus. https://app.cochat.ai/papers/10.1056/nejm198608073150605
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- Spechler, S. J., & Goyal, R. K. (1986). Barrett's Esophagus. New England Journal of Medicine. https://doi.org/10.1056/nejm198608073150605
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
