Cited by 176Gastroesophageal reflux and treatmentsGut microbiota and healthHelicobacter pylori-related gastroenterology studies

Gastric microbiota is altered in oesophagitis and B arrett's oesophagus and further modified by proton pump inhibitors

Amir, Itay, Konikoff, Fred M., Oppenheim, Michal, Gophna, Uri, Half, Elizabeth E.·2014·Environmental Microbiology

Abstract

Summary: Gastro‐oesophageal reflux can cause inflammation, metaplasia, dysplasia and cancer of the oesophagus. Despite the increased use of proton pump inhibitors ( PPIs ) to treat reflux, the incidence of oesophageal adenocarcinoma has increased rapidly in E urope and in the U nited S tates in the last 25 years. The reasons for this increase remain unclear. In this study, we aimed to determine whether the microbiota of the gastric refluxate and oesophageal biopsies differs between patients with heartburn and normal‐appearing oesophageal mucosa versus patients with abnormal oesophageal mucosa [oesophagitis or B arrett's oesophagus ( BE )] and to elucidate the effect of PPIs on the bacterial communities using 16 S rRNA gene pyrosequencing. Significant differences in the composition of gastric fluid bacteria were found between patients with heartburn and normal oesophageal tissue versus patients with oesophagitis or BE , but in the oesophagus‐associated microbiota differences were relatively modest. Notably, increased levels of E nterobacteriaceae were observed in the gastric fluid of oesophagitis and BE patients. In addition, treatment with PPIs had dramatic effects on microbial communities both in the gastric fluids and the oesophageal tissue. In conclusion, gastric fluid microbiota is modified in patients with oesophagitis and BE compared with heartburn patients with normal biopsies. Furthermore, PPI treatment markedly alters gastric and oesophageal microbial populations. Determining whether the changes in bacterial composition caused by PPIs are beneficial or harmful will require further investigation.

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Registry

Crossref · 10.1111/1462-2920.12285

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37 of 37 references verified0 citation errors · 0 not checkable

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  • PPI treatment can alter esophageal microbiota, causing an increase in the abundance of Firmicutes and a decrease in the abundance of Bacteroidetes and Proteobacteria.

    “PPI treatment can alter esophageal microbiota, causing an increase in the abundance of Firmicutes and a decrease in the abundance of Bacteroidetes and Proteobacteria[47].”

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Authors
Amir, I., Konikoff, F. M., Oppenheim, M., Gophna, U., & Half, E. E.
Affiliations
  • Tel Aviv University (IL)
  • Meir Medical Center (IL)
Corresponding author
Gophna, Uri
Venue
Environmental Microbiology
Publisher
Wiley
Published
2013-10-22
Volume
16
Issue
9
Pages
2905-2914
ISSN
  • 1462-2912 (ISSN-L)
  • 1462-2920
OpenAlex
W1914460529
Cited by
176
References
37
Citations by year
2026: 5 · 2025: 12 · 2024: 16 · 2023: 18 · 2022: 12 · 2021: 23 · 2020: 20 · 2019: 14 · 2018: 14 · 2017: 11 · 2016: 9 · 2015: 15 · 2014: 6 · 2013: 1
FWCI
9.76
Type
journal article
Language
en
Open access
closed
Locations
  • Environmental Microbiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Israel Cancer Association
Topics
  • Health Sciences › Medicine › Gastroenterology › Gastroesophageal reflux and treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Surgery › Helicobacter pylori-related gastroenterology studies
Keywords
gastric microbiota, esophagitis, Barrett's esophagus, proton pump inhibitors, gastroesophageal reflux, esophageal adenocarcinoma, Enterobacteriaceae, heartburn, dysplasia, metaplasia
MeSH terms
Bacteria, Barrett Esophagus, DNA, Bacterial, Esophagitis, Gastric Juice, Gastroesophageal Reflux, Humans, RNA, Ribosomal, 16S, Case-Control Studies, Sequence Analysis, DNA, Proton Pump Inhibitors, Microbiota

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