Human Infection with Ehrlichia canis, a Leukocytic Rickettsia
Abstract
RICKETTSIA that are pathogenic for humans include five main antigenic groups that cause, respectively, typhus, spotted fever, scrub typhus, Q fever, and trench fever.1 There is also a group of intraleukocytic parasites that infect humans and a variety of wild and domestic animals. These organisms constitute the genus ehrlichia of the family Rickettsiaceae.2 The human pathogen in this genus, E. sennetsu, was isolated in Japan in 1954 from a patient with an infectious mononucleosis–like syndrome.3 Sennetsu rickettsiosis was subsequently described in Japan and Malaysia.4 We now report a human infection caused by E. canis. The clinical symptoms of . . .
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The diseases studied have important zoonotic potential, as human infections or risk of infection have been described.
“we must consider the important zoonotic potential of the diseases studied, as the presence of human infections or risk of infection has already been described (5, 24, 25, 28).”
From Current Distribution of Selected Vector-Borne Diseases in Dogs in Spain (2020) · cites this paper as [24]
Cites
Serological Diagnosis of Tropical Canine Pancytopenia by Indirect Immunofluorescence
Ristic, M., Huxsoll, D. L., Weisiger, R. M., et al. (1972) · Infection and Immunity · doi:10.1128/iai.6.3.226-231.1972 · Cited by 170 · see citing works
Self-citationBuhles, W. C., Huxsoll, D. L., & Ristić, M. (1974) · The Journal of Infectious Diseases · doi:10.1093/infdis/130.4.357 · Cited by 129 · see citing works
Keefe, T. J., Holland, C. J., Salyer, P. E., et al. (1982) · Journal of the American Veterinary Medical Association · doi:10.2460/javma.1982.181.03.236 · Cited by 101 · see citing works
Acute Experimental Canine Ehrlichiosis
Reardon, M. J., & Pierce, K. R. (1981) · Veterinary Pathology · doi:10.1177/030098588101800106 · Cited by 83 · see citing works
Clinical and Clinicopathologic Findings in Tropical Canine Pancytopenia
Walker, J. S., Jd, R., Taylor, R., et al. (1970) · Journal of the American Veterinary Medical Association · doi:10.2460/javma.1970.157.01.43 · Cited by 59 · see citing works
Epidemiology of Rocky Mountain Spotted Fever as Determined by Active Surveillance
Wilfert, C. M., MacCormack, J. N., Kleeman, K. T., et al. (1984) · The Journal of Infectious Diseases · doi:10.1093/infdis/150.4.469 · Cited by 53 · see citing works
Ultrastructure of Ehrlichia canis
Hildebrandt, P. K., Conroy, J. D., McKee, A. E., et al. (1973) · Infection and Immunity · doi:10.1128/iai.7.2.265-271.1973 · Cited by 39 · see citing works
Ultrastructural observations on Ehrlichia equi organisms in equine granulocytes
Sells, D. M., Hildebrandt, P. K., Lewis, G. E., et al. (1976) · Infection and Immunity · doi:10.1128/iai.13.1.273-280.1976 · Cited by 31 · see citing works
Relationship of Ehrlichia canis -Infected Mononuclear Cells to Blood Vessels of Lungs
Simpson, C. F. (1974) · Infection and Immunity · doi:10.1128/iai.10.3.590-596.1974 · Cited by 24 · see citing works
Epizootiology of Tropical Canine Pancytopenia in Southeast Asia
Nims, R. M., Ferguson, J. A., Walker, J. L., et al. (1971) · Journal of the American Veterinary Medical Association · doi:10.2460/javma.1971.158.01.53 · Cited by 23 · see citing works
Retrospective Study of an Ehrlichia canis Epizootic Around Phoenix, Arizona
Stephenson, Ε. H., & Ristić, M. (1978) · Journal of the American Veterinary Medical Association · doi:10.2460/javma.1978.172.01.63 · Cited by 20 · see citing works
POSITIVE EHRLICHIA CANIS SEROLOGY IN KAWASAKI DISEASE
Edlinger, E., Benichou, J., & Labrune, B. (1980) · The Lancet · doi:10.1016/s0140-6736(80)91603-7 · Cited by 18 · see citing works
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Current Distribution of Selected Vector-Borne Diseases in Dogs in Spain
Montoya-Alonso, J. A., Morchón, R., Costa-Rodríguez, N., Matos, J. I., Falcón-Cordón, Y., & Carretón, E. (2020) · Frontiers in Veterinary Science · doi:10.3389/fvets.2020.564429 · Cited by 59 · see citing works
- Authors
- Maeda, K., Markowitz, N., Hawley, R. C., Ristic, M., Cox, D., & McDade, J. E.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1987-04-02
- Volume
- 316
- Issue
- 14
- Pages
- 853-856
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2079843643
- Cited by
- 493
- References
- 13
- Citations by year
- 2026: 8 · 2025: 6 · 2024: 9 · 2023: 5 · 2022: 8 · 2021: 16 · 2020: 5 · 2019: 5 · 2018: 5 · 2017: 7 · 2016: 12 · 2015: 12 · 2014: 15 · 2013: 5 · 2012: 10
- FWCI
- 14.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Parasitology › Vector-borne infectious diseases
- Life Sciences › Immunology and Microbiology › Parasitology › Bartonella species infections research
- Health Sciences › Medicine › Infectious Diseases › Viral Infections and Vectors
- Keywords
- Ehrlichia canis, human infection, Rickettsiaceae, zoonoses
- MeSH terms
- Antibodies, Bacterial, Bites and Stings, Inclusion Bodies, Ehrlichia, Humans, Leukocytes, Male, Middle Aged, Rickettsiaceae Infections, Ticks
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