Cited by 1,072Platelet Disorders and TreatmentsBlood Coagulation and Thrombosis MechanismsAntiplatelet Therapy and Cardiovascular Diseases

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Concurrent Morning Increase in Platelet Aggregability and the Risk of Myocardial Infarction and Sudden Cardiac Death

Tofler, Geoffrey H., Brezinski, Damian, Schafer, Andrew I., Czeisler, Charles A., Rutherford, John D., Willich, Stefan N., Gleason, Ray E., Williams, Gordon H., Muller, James E.·1987·New England Journal of Medicine

DOI 10.1056/nejm198706113162405

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Abstract

We have previously reported that the frequencies of myocardial infarction and of sudden cardiac death are highest during the period from 6 a.m. to noon. Since platelet aggregation may have a role in triggering these disorders, we measured platelet activity at 3-hour intervals for 24 hours in 15 healthy men. In vitro platelet responsiveness to either adenosine diphosphate (ADP) or epinephrine was lower at 6 a.m. (before the subjects arose) than at 9 a.m. (60 minutes after they arose). The lowest concentration of these agents required to produce biphasic platelet aggregation decreased (i.e., aggregability increased) from a mean +/- SEM of 4.7 +/- 0.6 to 3.7 +/- 0.6 microM (P less than 0.01) for ADP and from 3.7 +/- 0.8 to 1.8 +/- 0.5 microM (P less than 0.01) for epinephrine. The period from 6 to 9 a.m. was the only interval in the 24-hour period during which platelet aggregability increased significantly. We subsequently studied 10 subjects on alternate mornings after they arose at the normal time and after delayed arising. The morning increase in platelet aggregability was not observed when the subjects remained supine and inactive. Thus, there is a temporal association between increased platelet aggregability in the morning and an increased frequency of myocardial infarction and of sudden cardiac death. Demonstration of this association does not establish a cause--effect relation, but together with other evidence linking platelets to these disorders, it may provide insight into the mechanisms precipitating myocardial infarction and sudden cardiac death and aid in the design of more effective preventive measures.

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Aggregation of Blood Platelets by Adenosine Diphosphate and its Reversal
Born, G. V. R. (1962) · Nature · doi:10.1038/194927b0 · Cited by 4,296
Plaque fissuring--the cause of acute myocardial infarction, sudden ischaemic death, and crescendo angina.
Davies, M. J., & Thomas, A. C. (1985) · Heart · doi:10.1136/hrt.53.4.363 · Cited by 1,985
HAEMOSTATIC FUNCTION AND ISCHAEMIC HEART DISEASE: PRINCIPAL RESULTS OF THE NORTHWICK PARK HEART STUDY
Meade, T. W., Brozović, M., Chakrabarti, R., Haines, A., Imeson, J., Mellows, S., Miller, G. J., North, W. R. S., Stirling, Y., & Thompson, S. G. (1986) · The Lancet · doi:10.1016/s0140-6736(86)90111-x · Cited by 1,937
Simultaneous single isotope radioenzymatic assay of plasma norepinephrine, epinephrine and dopamine
Peuler, J. D., & Johnson, G. A. (1977) · Life Sciences · doi:10.1016/0024-3205(77)90070-4 · Cited by 1,899
Circadian Variation in the Frequency of Onset of Acute Myocardial Infarction
Muller, J. E., Stone, P. H., Turi, Z. G., Rutherford, J. D., Czeisler, C. A., Parker, C., Poole, W. K., Passamani, E., Roberts, R., Robertson, T., et al. (1985) · New England Journal of Medicine · doi:10.1056/nejm198511213132103 · Cited by 1,884
Self-citation
Protective Effects of Aspirin against Acute Myocardial Infarction and Death in Men with Unstable Angina
Lewis, H. D., Davis, J. W., Archibald, D., Steinke, W. E., Smitherman, T. C., Doherty, J. E., Schnaper, H. W., LeWinter, M. M., Linares, E., Pouget, J. M., et al. (1983) · New England Journal of Medicine · doi:10.1056/nejm198308183090703 · Cited by 1,708
Thrombosis and Acute Coronary-Artery Lesions in Sudden Cardiac Ischemic Death
Davies, M. J., & Thomas, A. (1984) · New England Journal of Medicine · doi:10.1056/nejm198405033101801 · Cited by 1,694
Fibrinogen as a Risk Factor for Stroke and Myocardial Infarction
Wilhelmsen, L., Svärdsudd, K., Korsan-Bengtsen, K., Larsson, B., Welin, L., & Tibblin, G. (1984) · New England Journal of Medicine · doi:10.1056/nejm198408233110804 · Cited by 1,645
Circadian variation of blood-pressure
Millar-Craig, M., Bishop, C., & Raftery, E. B. (1978) · The Lancet · doi:10.1016/s0140-6736(78)92998-7 · Cited by 1,293
Platelet Activation in Unstable Coronary Disease
Fitzgerald, D. J., Roy, L., Catella, F., & FitzGerald, G. A. (1986) · New England Journal of Medicine · doi:10.1056/nejm198610163151602 · Cited by 1,141

Show all 35 references

Research works printed but not linked: 2

Petralito, 1982, Chronobiologia, 9, 195
Nubile, 1982, Boll Soc Ital Biol Sper, 62, 947

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Peters, R. W., McQuillan, S., & Gold, M. R. (1999) · The American Journal of Cardiology · doi:10.1016/s0002-9149(99)00376-8 · Cited by 26
Circadian and circannual rhythm of nonfatal pulmonary embolism
Sharma, G. V. R. K., Frisbie, J. H., Tow, D. E., Yalla, S. V., & Khuri, S. F. (2001) · The American Journal of Cardiology · doi:10.1016/s0002-9149(00)01542-3 · Cited by 26
Formation of platelet aggregates after attacks of coronary spastic angina pectoris
Miyamoto, S., Ogawa, H., Soejima, H., Takazoe, K., Sakamoto, T., Yoshimura, M., Kugiyama, K., & Yasue, H. (2000) · The American Journal of Cardiology · doi:10.1016/s0002-9149(99)00779-1 · Cited by 26
Effect of concentrated ambient particulate matter on blood coagulation parameters in rats.
Nadziejko, C. E., Fang, K., Chen, L., Cohen, B. S., Karpatkin, M., & Nadas, A. J. (2002) · PubMed · Cited by 26
Circadian Distribution of In-Hospital Cardiopulmonary Arrests on the General Medical Ward
Buff, D. D. (1992) · Archives of Internal Medicine · doi:10.1001/archinte.152.6.1282 · Cited by 26
Modification of the circadian rhythm of onset of acute myocardial infarction by long-term antianginal treatment
WOODS, K. L., Fletcher, S., & Jagger, C. (1992) · Heart · doi:10.1136/hrt.68.11.458 · Cited by 26
Cardiovascular Risk Factors in the Circadian Rhythm of Acute Myocardial Infarction
Messa, J. B. L., Garmendia-Leiza, J. R., García, M. D. A., de Llano, J. M. A., Alberola‐López, C., & Fernández, J. A. (2004) · Revista Española de Cardiología (English Edition) · doi:10.1016/s1885-5857(06)60650-6 · Cited by 25
Circadian Variation of Vasovagal Syncope
Mineda, Y., Sumiyoshi, M., Tokano, T., Yasuda, M., Nakazato, K., Nakazato, Y., Nakata, Y., & Yamaguchi, H. (2000) · Journal of Cardiovascular Electrophysiology · doi:10.1111/j.1540-8167.2000.tb01751.x · Cited by 25
Two-Peak Temporal Distribution of Stroke Onset in Greek Patients
Spengos, K. M., Vemmos, K. N., Tsivgoulis, G. K., Synetos, A. G., Zakopoulos, N., Zis, V., & Vassilopoulos, D. (2003) · Cerebrovascular Diseases · doi:10.1159/000067129 · Cited by 25
Triggers and the Onset of Acute Myocardial Infarction
Hammoudeh, A. J., & Alhaddad, I. A. (2009) · Cardiology in Review · doi:10.1097/crd.0b013e3181bdba75 · Cited by 27
Mental Stress-Induced Platelet Activation Among Patients With Coronary Artery Disease
Reid, G. J., Seidelin, P. H., Kop, W. J., Irvine, M. J., Strauss, B. H., Nolan, R. P., Lau, H. K. F., & Yeo, E. L. (2009) · Psychosomatic Medicine · doi:10.1097/psy.0b013e31819cc751 · Cited by 25
Characterization of an original model of myocardial infarction provoked by coronary artery thrombosis induced by ferric chloride in pig
Dogné, J., Rolin, S., Pétein, M., Tchana‐Sato, V., Ghuysen, A., Lambermont, B. C., Hanson, J., Magis, D., Segers, P., Pirotte, B., et al. (2005) · Thrombosis Research · doi:10.1016/j.thromres.2005.02.006 · Cited by 25
Cardiovascular Consequences of Sleep-related Breathing Disorders
Bananian, S., Lehrman, S. G., & Maguire, G. P. (2002) · Heart Disease · doi:10.1097/00132580-200209000-00006 · Cited by 24
Idiopathic Ventricular Fibrillation
Marcus, G. M. (1997) · Journal of Cardiovascular Electrophysiology · doi:10.1111/j.1540-8167.1997.tb00632.x · Cited by 25
Effect of systemic alpha-2 adrenergic blockade on the morning increase in platelet aggregation in normal subjects
Andrews, N. P., Goldstein, D. S., & Quyyumi, A. A. (1999) · The American Journal of Cardiology · doi:10.1016/s0002-9149(99)00283-0 · Cited by 25
Circadian Variation in the Onset of Acute Critical Limb Ischemia
Manfredini, R., Gallerani, M., Portaluppi, F., Salmi, R., Zamboni, P., & FERSINI, C. (1998) · Thrombosis Research · doi:10.1016/s0049-3848(98)00127-3 · Cited by 24
Can nutrition influence circadian rhythm and heart rate variability?
Singh, R. B., Weydahl, A., Otsuka, K., Watanabe, Y., Yano, S., Mori, H., Ichimaru, Y., Mitsutake, G., Sato, Y., Lu, F., et al. (2000) · Biomedicine & Pharmacotherapy · doi:10.1016/s0753-3322(01)90016-2 · Cited by 24
Antiplatelet effect of aspirin in patients with coronary artery disease.
Grove, E. L. (2012) · PubMed · Cited by 24
Circadian variation in endothelial function is attenuated in postmenopausal women
Walters, J. F., Hampton, S. M., Deanfield, J. E., Donald, A. E., Skene, D. J., & Ferns, G. A. (2006) · Maturitas · doi:10.1016/j.maturitas.2005.12.005 · Cited by 24
Upright posture and maximal exercise increase platelet aggregability and prostacyclin production in healthy male subjects.
Feng, D., Murillo, J. E., Jadhav, P., McKenna, C., Gebara, O., Lipinska, I., Muller, J. E., & Tofler, G. H. (1999) · British Journal of Sports Medicine · doi:10.1136/bjsm.33.6.401 · Cited by 24
Self-citation
An association between snowfall and ED presentation of cardiac arrest
Spitalnic, S. J., Jagminas, L., & Cox, J. (1996) · The American Journal of Emergency Medicine · doi:10.1016/s0735-6757(96)90102-3 · Cited by 24
Heart rate–corrected QT interval in men increases during winter months
Beyerbach, D. M., Kovacs, R. J., Dmitrienko, A. A., Rebhun, D. M., & Zipes, D. P. (2006) · Heart Rhythm · doi:10.1016/j.hrthm.2006.11.008 · Cited by 24
Longitudinal Study of Acute Myocardial Infarction in the Southeast Osaka District From 1988 to 2002
Kinoshita, N., 今井, 克., Kinjo, K., & Naka, M. (2005) · Circulation Journal · doi:10.1253/circj.69.1170 · Cited by 24
Cerebrovascular disease and the pathophysiology of obstructive sleep apnea
Culebras, A. (2007) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-007-0014-6 · Cited by 24
Effects of circulating norepinephrine on platelet, leukocyte and red blood cell counts by alpha1-adrenergic stimulation
Sloand, J. A., Hooper, M., & Izzo, J. L. (1989) · The American Journal of Cardiology · doi:10.1016/0002-9149(89)90096-9 · Cited by 24
Hypertension and chronotherapy: shifting the treatment paradigm
Prisant, L. M. (2001) · American Journal of Hypertension · doi:10.1016/s0895-7061(01)02173-2 · Cited by 24
Should we get up in the morning? Observations on circadian variations in cardiac events.
Mulcahy, D., Purcell, H., & Fox, K. (1991) · Heart · doi:10.1136/hrt.65.6.299 · Cited by 24
Design and baseline results of the monosialoganglioside early stroke trial. The EST Study Group.
Rocca, W. A., Dorsey, F. C., Grigoletto, F., Gent, M., Roberts, R. S., WALKER, M. D., Easton, J. D., Bruno, R., Carolei, A., & Sancesario, G. (1992) · Stroke · doi:10.1161/01.str.23.4.519 · Cited by 23

Authors: Tofler, G. H., Brezinski, D., Schafer, A. I., Czeisler, C. A., Rutherford, J. D., Willich, S. N., Gleason, R. E., Williams, G. H., & Muller, J. E.
Affiliations: Brigham and Women's Hospital (US)
ORCID: Tofler, Geoffrey H.
Schafer, Andrew I.
Czeisler, Charles A.
Williams, Gordon H.
Muller, James E.
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 1987-06-11
Volume: 316
Issue: 24
Pages: 1514-1518
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejm198706113162405
OpenAlex: W1974742589
Cited by: 1,072
References: 35
Citations by year: 2026: 7 · 2025: 14 · 2024: 8 · 2023: 13 · 2022: 22 · 2021: 18 · 2020: 11 · 2019: 18 · 2018: 16 · 2017: 22 · 2016: 18 · 2015: 21 · 2014: 28 · 2013: 27 · 2012: 29
FWCI: 21.71
Type: journal article
Language: en
Open access: closed
Locations: New England Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
Funders: U.S. Public Health Service (9535 A607606)
National Heart, Lung, and Blood Institute (HL-27465, HL-705861)
Topics: Health Sciences › Medicine › Hematology › Platelet Disorders and Treatments
Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Antiplatelet Therapy and Cardiovascular Diseases
Keywords: platelet aggregability, circadian rhythm, myocardial infarction, sudden cardiac death, adenosine diphosphate, epinephrine, supine rest, platelet function
MeSH terms: Adenosine Diphosphate, Adult, Death, Sudden, Epinephrine, Hematocrit, Humans, Male, Myocardial Infarction, Platelet Aggregation, Platelet Count, Posture, Time, In Vitro Techniques

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Concurrent Morning Increase in Platelet Aggregability and the Risk of Myocardial Infarction and Sudden Cardiac Death

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