Plaque fissuring--the cause of acute myocardial infarction, sudden ischaemic death, and crescendo angina.
Open accessAbstract
The clinical management of acute myocardial infarc- tion and crescendo angina as well as the prevention of sudden ischaemic death require accurate knowledge of the underlying arterial pathology.It is on just this aspect that until recently there has been disagreement particularly among pathologists.In brief, this con- troversy was concerned with whether coronary artery thrombi were or were not directly responsible for all three clinical pictures of acute ischaemia.Resolution of the controversy has been derived from coronary angiography in life in patients with acute infarction and crescendo angina and from detailed pathological studies.These latter studies dif- fer from many carried out previously by the use of postmortem coronary angiography and histological reconstruction of the microanatomy of occlusive lesions.
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The effects of usual frequency of physical exertion on the relative risks of sudden death from cardiac causes and on fatal acute myocardial infarction are remarkably similar, providing support for the possibility that many cases of sudden death due to cardiac causes triggered by exertion have a pathophysiology similar to that of nonfatal acute myocardial infarction.
“The effects of the usual frequency of physical exertion on the relative risks of sudden death from cardiac causes and onfatal acute myocardial infarction are remarkably similar, providing support for the possibility that many cases of sudden death due to cardiac causes that are triggered by exertion have a pathophysiology similar to that of nonfatal acute myocardial infarction.21”
From Triggering of Acute Myocardial Infarction by Heavy Physical Exertion -- Protection against Triggering by Regular Exertion (1993) · cites this paper as [21]
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Experimental — accuracy not yet measuredFissuring or rupture of an atherosclerotic plaque commonly is the immediate antecedent to activation of the thrombosis cascade.
“The fissuring or rupture of an atherosclerotic plaque commonly is the immediate antecedent to the activation of the thrombosis cascade.99”
From Obesity Paradox in Hypertension: Is This Because Sympathetic Activation in Obesity-Hypertension Takes a Benign Form? (2018) · cites this paper as [99]
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Cites
Prevalence of Total Coronary Occlusion during the Early Hours of Transmural Myocardial Infarction
DeWood, M. A., Spores, J., Notske, R. N., Mouser, L. T., Burroughs, R., Golden, M. S., & Lang, H. T. (1980) · New England Journal of Medicine · doi:10.1056/nejm198010163031601 · Cited by 2,729 · see citing works
Reimer, K. A., Lowe, J. E., Rasmussen, M. M., & Jennings, R. B. (1977) · Circulation · doi:10.1161/01.cir.56.5.786 · Cited by 1,944 · see citing works
Lewis, H. D., Davis, J. W., Archibald, D., Steinke, W. E., Smitherman, T. C., Doherty, J. E., Schnaper, H. W., LeWinter, M. M., Linares, E., Pouget, J. M., et al. (1983) · New England Journal of Medicine · doi:10.1056/nejm198308183090703 · Cited by 1,708 · see citing works
Thrombosis and Acute Coronary-Artery Lesions in Sudden Cardiac Ischemic Death
Davies, M. J., & Thomas, A. (1984) · New England Journal of Medicine · doi:10.1056/nejm198405033101801 · Cited by 1,694 · see citing works
Self-citationHypothesis: Vasa Vasorum and Neovascularization of Human Coronary Arteries
Barger, A. C., Beeuwkes, R., Lainey, L. L., & Silverman, K. (1984) · New England Journal of Medicine · doi:10.1056/nejm198401193100307 · Cited by 850 · see citing works
Coronary Vasospasm as a Possible Cause of Myocardial Infarction
Maseri, A., L’Abbate, A., Baroldi, G., Chierchia, S. L., Marzilli, M., Ballestra, A. M., Severi, S., Parodi, O., Biagini, A., Distante, A., et al. (1978) · New England Journal of Medicine · doi:10.1056/nejm197812072992303 · Cited by 841 · see citing works
Thrombosis as a factor in the pathogenesis of coronary atherosclerosis
Duguid, J. B. (1946) · The Journal of Pathology and Bacteriology · doi:10.1002/path.1700580207 · Cited by 798 · see citing works
Intracoronary thrombolysis in evolving myocardial infarction
Ganz, W., Buchbinder, N. A., Marcus, H. S., Mondkar, A. M., Maddahi, J., Charuzi, Y., O'Connor, L. R., Shell, W. E., Fishbein, M. C., Kass, R. M., et al. (1981) · American Heart Journal · doi:10.1016/0002-8703(81)90376-8 · Cited by 587 · see citing works
Arteriographic evidence of coronary arterial spasm in acute myocardial infarction.
Oliva, P. B., & Breckinridge, J. C. (1977) · Circulation · doi:10.1161/01.cir.56.3.366 · Cited by 517 · see citing works
Non surgical coronary artery recanalization in acute transmural myocardial infarction.
Mathey, D. G., Kück, K., Tilsner, V., Krebber, H.-J., & Bleifeld, W. (1981) · Circulation · doi:10.1161/01.cir.63.3.489 · Cited by 460 · see citing works
Plaque fissures in human coronary thrombosis
Constantinides, P. (1966) · Journal of Atherosclerosis Research · doi:10.1016/s0368-1319(66)80056-x · Cited by 427 · see citing works
Roberts, W. C., & Buja, L. M. (1972) · The American Journal of Medicine · doi:10.1016/0002-9343(72)90033-2 · Cited by 415 · see citing works
Levin, D. C., & Fallon, J. T. (1982) · Circulation · doi:10.1161/01.cir.66.2.316 · Cited by 398 · see citing works
Survival after Resuscitation from Out-of-Hospital Ventricular Fibrillation
Baum, R. S., Alvarez, H., & Cobb, L. A. (1974) · Circulation · doi:10.1161/01.cir.50.6.1231 · Cited by 364 · see citing works
Rethrombosis after reperfusion with streptokinase: importance of geometry of residual lesions.
Harrison, D. G., Ferguson, D. W., Collins, S. M., et al. (1984) · Circulation · doi:10.1161/01.cir.69.5.991 · Cited by 321 · see citing works
Pathophysiologic Observations in Prehospital Ventricular Fibrillation and Sudden Cardiac Death
Liberthson, R. R., Nagel, E. L., Hirschman, J. C., Nussenfeld, S. R., Blackbourne, B. D., & Davis, J. H. (1974) · Circulation · doi:10.1161/01.cir.49.5.790 · Cited by 315 · see citing works
Meyer, J., Merx, W., Schmitz, H. J., et al. (1982) · Circulation · doi:10.1161/01.cir.66.5.905 · Cited by 307 · see citing works
Intimal vascularisation and atherosclerosis
Geiringer, E. (1951) · The Journal of Pathology and Bacteriology · doi:10.1002/path.1700630204 · Cited by 295 · see citing works
Coronary thrombosis in myocardial infarction
Chandler, A. B., Chapman, I., Erhardt, L., et al. (1974) · The American Journal of Cardiology · doi:10.1016/0002-9149(74)90703-6 · Cited by 283 · see citing works
Pathology of acute myocardial infarction with particular reference to occlusive coronary thrombi.
Davies, M. J., WOOLF, N. J., & Robertson, W. B. (1976) · Heart · doi:10.1136/hrt.38.7.659 · Cited by 272 · see citing works
Self-citationThrombosis as a factor in the pathogenesis of aortic atherosclerosis
Duguid, J. B. (1948) · The Journal of Pathology and Bacteriology · doi:10.1002/path.1700600107 · Cited by 272 · see citing works
Ridolfi, R. L., & Hutchins, G. M. (1977) · American Heart Journal · doi:10.1016/s0002-8703(77)80410-9 · Cited by 270 · see citing works
Horie, T., Sekiguchi, M., & HIROSAWA, K. (1978) · Heart · doi:10.1136/hrt.40.2.153 · Cited by 228 · see citing works
Intravenous streptokinase in evolving acute myocardial infarction
Ganz, W., Geft, I. L., Shah, P. K., et al. (1984) · The American Journal of Cardiology · doi:10.1016/0002-9149(84)90066-3 · Cited by 222 · see citing works
Reduto, L. A., Smalling, R. W., Freund, G. C., et al. (1981) · The American Journal of Cardiology · doi:10.1016/0002-9149(81)90066-7 · Cited by 208 · see citing works
Intracoronary thrombus in syndromes of unstable myocardial ischemia
Vetrovec, G. W., Cowley, M. J., Overton, H., & Richardson, D. C. (1981) · American Heart Journal · doi:10.1016/0002-8703(81)90653-0 · Cited by 207 · see citing works
Serruys, P. W. J. C., Wijns, W. C., van den Brand, M., et al. (1983) · Heart · doi:10.1136/hrt.50.3.257 · Cited by 192 · see citing works
Acute myocardial infarction and angiographically normal coronary arteries. An unproven combination.
Arnett, E. N., & Roberts, W. C. (1976) · Circulation · doi:10.1161/01.cir.53.3.395 · Cited by 168 · see citing works
Intracoronary thrombolysis in syndromes of unstable ischemia: Angiographic and clinical results
Vetrovec, G. W., Leinbach, R. C., Gold, H. K., et al. (1982) · American Heart Journal · doi:10.1016/0002-8703(82)90268-x · Cited by 148 · see citing works
Acute Coronary Insufficiency — Coronary Occlusion after Intermittent Ischemic Attacks
Neill, W. A., Wharton, T. P., Fluri‐Lundeen, J., et al. (1980) · New England Journal of Medicine · doi:10.1056/nejm198005223022101 · Cited by 134 · see citing works
Crawford, T., & Levene, C. I. (1953) · The Journal of Pathology and Bacteriology · doi:10.1002/path.1700660104 · Cited by 123 · see citing works
The pathological basis and microanatomy of occlusive thrombus formation in human coronary arteries
Davies, M. J., Thomas, T., & surName (1981) · Philosophical transactions of the Royal Society of London. Series B, Biological sciences · doi:10.1098/rstb.1981.0101 · Cited by 121 · see citing works
Self-citationAcute coronary occlusion as a cause of myocardial infarct and sudden coronary heart death
Baroldi, G. (1965) · The American Journal of Cardiology · doi:10.1016/0002-9149(65)90704-6 · Cited by 120 · see citing works
THE RELATIONSHIP OF CORONARY THROMBOSIS TO CORONARY ATHEROSCLEROSIS AND ISCHEMIC HEART DISEASE
Spain, D. M., & BRADESS, V. A. (1960) · The American Journal of the Medical Sciences · doi:10.1097/00000441-196012000-00003 · Cited by 115 · see citing works
Herem, J. W. (1974) · Atherosclerosis · doi:10.1016/s0021-9150(74)80017-1 · Cited by 108 · see citing works
Erhardt, L., Lundman, T., & Mellstedt, H. (1973) · The Lancet · doi:10.1016/s0140-6736(73)90249-3 · Cited by 106 · see citing works
Coronary arteriosclerosis, coronary thrombosis, and the resulting myocardial changes
Saphir, O., Priest, W. S., Hamburger, W. W., et al. (1935) · American Heart Journal · doi:10.1016/s0002-8703(35)90251-4 · Cited by 105 · see citing works
El-Maraghi, N. R. H., & Genton, E. (1980) · Circulation · doi:10.1161/01.cir.62.5.936 · Cited by 102 · see citing works
The coronary thrombus: Its origin and fate
Friedman, M. (1971) · Human Pathology · doi:10.1016/s0046-8177(71)80022-9 · Cited by 96 · see citing works
Mathey, D. G., Rodewald, G., Rentrop, P., et al. (1981) · American Heart Journal · doi:10.1016/0002-8703(81)90652-9 · Cited by 95 · see citing works
The relation of coronary thrombosis to ischaemic myocardial necrosis
Davies, M. J., Fulton, W. F. M., & Robertson, W. B. (1979) · The Journal of Pathology · doi:10.1002/path.1711270208 · Cited by 89 · see citing works
Self-citationProgression of coronary atherosclerosis. Clues to pathogenesis from serial coronary arteriography.
Singh, R. N. (1984) · Heart · doi:10.1136/hrt.52.4.451 · Cited by 81 · see citing works
Silver, M. D., Baroldi, G., & Mariani, F. (1980) · Circulation · doi:10.1161/01.cir.61.2.219 · Cited by 79 · see citing works
Morphology of acute myocardial infarction in relation to coronary thrombosis
Baroldi, G., Radice, F., Schmid, G., et al. (1974) · American Heart Journal · doi:10.1016/0002-8703(74)90392-5 · Cited by 79 · see citing works
Intracoronary streptokinase in clinical practice
TIMMIS, G. C., Gangadharan, V., Hauser, A. M., et al. (1982) · American Heart Journal · doi:10.1016/0002-8703(82)90266-6 · Cited by 78 · see citing works
Chapman, I. (1974) · American Heart Journal · doi:10.1016/0002-8703(74)90062-3 · Cited by 66 · see citing works
Kasper, W. E., Erbel, R. M., Meinertz, T., et al. (1984) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(84)80226-0 · Cited by 65 · see citing works
High-dose, brief intravenous streptokinase early in acute myocardial infarction
Spann, J. F., Sherry, S., Carabello, B. A., et al. (1982) · American Heart Journal · doi:10.1016/0002-8703(82)90267-8 · Cited by 64 · see citing works
Vascularization and hemorrhage of the intima of arteriosclerotic coronary arteries
(1937) · American Heart Journal · doi:10.1016/s0002-8703(37)90949-9 · Cited by 53 · see citing works
Erhardt, L., Unge, G., & Boman, G. (1976) · American Heart Journal · doi:10.1016/s0002-8703(76)80144-5 · Cited by 47 · see citing works
Mechanisms and frequency of thrombosis in the coronary circulation
Chandler, A. B. (1974) · Thrombosis Research · doi:10.1016/0049-3848(74)90144-3 · Cited by 39 · see citing works
Angiographic features of the coronary arteries during intracoronary thrombolysis.
Terrosu, P., Ibba, G. V., Contini, G. M., et al. (1984) · Heart · doi:10.1136/hrt.52.2.154 · Cited by 30 · see citing works
Intracoronary thrombolysis in acute myocardial infarction.
Brooks, N. H. (1983) · Heart · doi:10.1136/hrt.50.5.397 · Cited by 25 · see citing works
McGregor, M., L’Abbate, A., Mildenberger, R. R., et al. (1976) · PubMed · Cited by 24 · see citing works
Myocardial infarction and the normal coronary arteriogram.
Fox, K. M. (1983) · BMJ · doi:10.1136/bmj.287.6390.446 · Cited by 7 · see citing works
INTRACORONARY THROMBOLYSIS IN ACUTE MYOCARDIAL INFARCTION
Kanmatsuse, K., Kajiwara, N., Onikura, S., et al. (1982) · Nihon Naika Gakkai Zasshi · doi:10.2169/naika.71.1713 · Cited by 2 · see citing works
Mayer, G., Story, W., Seco, J., et al. (1984) · Annals of Emergency Medicine · doi:10.1016/s0196-0644(84)80183-3 · Cited by 1 · see citing works
Flagged first, then by citations
Research works printed but not linked: 4
- Davies, Thomas on July 19, 2023 by guest. Protected by copyright. http://heart.bmj.com/ Br Heart J: first published as 10.1136/hrt.53.4.363 on 1 April 1985. Downloaded from Plaquefissuring-the cause of acute myocardial infarction, infarct size vs duration of coronary occlusion in dogs. Circulation 1977; 56: 786-94.
- Fulton WFM, Sumner DG. 125 1 labelled fibrinogen, autoradiog- raphy, and stereo-arteriography in identification of coronary thrombotic occlusion in fatal myocardial infarction [AbstractJ. Br Heartj 1976; 38: 880.
- Benson RL. The present status of coronary arterial disease. Arch Pathol 1926; 2: 876-916.
- Paterson JC. Capillary rupture with intimal hemorrhage as a causative factor in coronary thrombosis. Arch Pathol 1938; 25: 474-87.
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- Authors
- Davies, M. J., & Thomas, A. C.
- Affiliations
- St George's, University of London (GB)
- ORCID
- Davies, M J
- Venue
- Heart
- Publisher
- BMJ
- Published
- 1985-04-01
- Volume
- 53
- Issue
- 4
- Pages
- 363-373
- ISSN
- 1355-6037 (ISSN-L)
- PMC
- PMC481773
- OpenAlex
- W2081527966
- Cited by
- 1,985
- References
- 57
- Citations by year
- 2026: 8 · 2025: 12 · 2024: 18 · 2023: 15 · 2022: 11 · 2021: 19 · 2020: 19 · 2019: 25 · 2018: 25 · 2017: 31 · 2016: 30 · 2015: 31 · 2014: 42 · 2013: 29 · 2012: 43
- FWCI
- 7.95
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Heart (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
- Health Sciences › Medicine › Surgery › Coronary Interventions and Diagnostics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
- Keywords
- acute myocardial infarction, coronary thrombus, coronary artery pathology, coronary angiography
- MeSH terms
- Adult, Angina Pectoris, Arteriosclerosis, Coronary Disease, Coronary Vessels, Death, Sudden, Humans, Male, Myocardial Infarction, Coronary Angiography
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