The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Short-Term Metabolic Effects of Recombinant Human Insulin-like Growth Factor I in Healthy Adults
Abstract
Insulin-like growth factor I (IGF I) is structurally similar to insulin and shares many of its biologic properties. We compared the short-term metabolic effects of recombinant IGF I (100 micrograms [13.3 nmol] per kilogram of body weight) and insulin (0.15 IU [1 nmol] per kilogram) in eight healthy volunteers (four men and four women). The hypoglycemic responses to both hormones were nearly identical in the doses used. The lowest blood glucose levels were reached after 30 minutes: 1.98 +/- 0.44 mmol per liter after IGF I and 1.78 +/- 0.29 after insulin. On a molar basis, IGF I was only 6 percent as potent as insulin in the production of hypoglycemia. Insulin also inhibited lipolysis more effectively than IGF I. Levels of epinephrine, norepinephrine, growth hormone, glucagon, and cortisol responded similarly to both agents. The hypoglycemia produced by IGF I is probably due to the supraphysiologic concentrations of the free peptide that result from its rapid intravenous injection. Fifteen minutes after injection, the serum level of IGF I increased from 144 +/- 38 ng per milliliter at base line to 424 +/- 56, of which 80 percent was free in the plasma (not bound to IGF carrier proteins). The determination of whether any of the short-term metabolic effects of IGF I have any clinical application will require further investigation.
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Cites
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Primary structure of human insulin‐like growth factor II
Rinderknecht, E., & Humbel, R. E. (1978) · FEBS Letters · doi:10.1016/0014-5793(78)80237-3 · Cited by 780
An easy colorimetric micromethod for routine determination of free fatty acids in plasma
Falholt, K., Lund, B., & Falholt, W. (1973) · Clinica Chimica Acta · doi:10.1016/0009-8981(73)90016-8 · Cited by 633
Insulin-like growth factor I stimulates growth in hypophysectomized rats
Schoenle, E., Zapf, J., Humbel, R. E., & Froesch, E. R. (1982) · Nature · doi:10.1038/296252a0 · Cited by 596
Self-citationZapf, J., Walter, H., & Froesch, E. R. (1981) · Journal of Clinical Investigation · doi:10.1172/jci110379 · Cited by 595
Self-citationRegulation of insulin-like growth factor I gene expression by growth hormone.
Mathews, L. S., Norstedt, G., & Palmiter, R. D. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.24.9343 · Cited by 553
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Cited by
The Somatomedin Hypothesis: 2001
Le Roith, D., Bondy, C., Yakar, S., Liu, J.-L., & Butler, A. (2001) · Endocrine Reviews · doi:10.1210/edrv.22.1.0419 · Cited by 1,257
Human growth hormone and human aging
CORPAS, E., HARMAN, S. M., & BLACKMAN, M. R. (1993) · Endocrine Reviews · doi:10.1210/edrv-14-1-20 · Cited by 911
Insulin-like growth factor 1 (IGF-1): a growth hormone
Laron, Z. (2001) · Molecular Pathology · doi:10.1136/mp.54.5.311 · Cited by 608
Binding proteins for the insulin-like growth factors: Structure, regulation and function
Baxter, R. C., & Martin, J. L. (1989) · Progress in Growth Factor Research · doi:10.1016/0955-2235(89)90041-0 · Cited by 566
Guler, H. P., Zapf, J., Scheiwiller, E., & Froesch, E. R. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.13.4889 · Cited by 422
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Metadata
- Authors
- Guler, H.-P., Zapf, J., & Froesch, E. R.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1987-07-16
- Volume
- 317
- Issue
- 3
- Pages
- 137-140
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2081096579
- Cited by
- 554
- References
- 17
- FWCI
- 14.88
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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