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Regulation of insulin-like growth factor I gene expression by growth hormone.
Open accessAbstract
Recombinant clones containing exon 3 of the insulin-like growth factor I (IGF-I) gene were isolated from a mouse genomic library. These sequences were used to generate an RNA probe, which was used in a solution hybridization assay to quantitate IGF-I mRNA in various murine tissues as a function of growth hormone status. The liver is the major site of IGF-I synthesis and the level of IGF-I mRNA is regulated about 10-fold by growth hormone in the growth hormone-deficient lit/lit mouse. Nuclear run-on assays were used to show that growth hormone regulation is manifested in part at the transcriptional level. Growth hormone also affects the size distribution of hepatic IGF-I mRNAs. Pancreas showed the highest non-hepatic expression, but every tissue analyzed contained some IGF-I mRNA. Expression was not growth hormone-dependent in most non-hepatic tissues.
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Citations
Cited by
Role of insulin-like growth factors in embryonic and postnatal growth
Baker, J., Liu, J.-P., Robertson, E. J., & Efstratiadis, A. (1993) · Cell · doi:10.1016/s0092-8674(05)80085-6 · Cited by 2,463
Roles of Growth Hormone and Insulin-like Growth Factor 1 in Mouse Postnatal Growth
Lupu, F., Terwilliger, J. D., Lee, K., Segre, G. V., & Efstratiadis, A. (2001) · Developmental Biology · doi:10.1006/dbio.2000.9975 · Cited by 771
Beck, K. D., Powell-Braxtont, L., Widmer, H.-R., Valverde, J., & Hefti, F. (1995) · Neuron · doi:10.1016/0896-6273(95)90216-3 · Cited by 636
Mechanism of the Stimulatory Effect of Growth Hormone on Longitudinal Bone Growth*
ISAKSSON, O. G. P., LINDAHL, A., NILSSON, A., & ISGAARD, J. (1987) · Endocrine Reviews · doi:10.1210/edrv-8-4-426 · Cited by 580
Short-Term Metabolic Effects of Recombinant Human Insulin-like Growth Factor I in Healthy Adults
Guler, H.-P., Zapf, J., & Froesch, E. R. (1987) · New England Journal of Medicine · doi:10.1056/nejm198707163170303 · Cited by 554
Metadata
- Authors
- Mathews, L. S., Norstedt, G., & Palmiter, R. D.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1986-12
- Volume
- 83
- Issue
- 24
- Pages
- 9343-9347
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2026870334
- Cited by
- 553
- References
- 0
- FWCI
- 20.99
- Type
- journal article
- Language
- en
- Open access
- green
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- Mathews, L. S., Norstedt, G., & Palmiter, R. D. (1986). Regulation of insulin-like growth factor I gene expression by growth hormone. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.83.24.9343
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