The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Latent Herpes Simplex Virus in Human Trigeminal Ganglia
Abstract
We used in situ hybridization to study the expression of herpes simplex virus type 1 genes during latent infections of human sensory ganglia. Trigeminal ganglia were recovered at autopsy from 24 subjects with no evidence of an active herpetic infection. These ganglia were hybridized to 35S-labeled single-stranded RNA probes spanning 72 percent of the herpes simplex genome. In the ganglia of 16 subjects, 0.2 to 4.3 percent of the neuronal cells contained abundant nuclear signals for viral RNA. Ganglia from three patients with low or undetectable levels of antibodies to herpes simplex type 1 lacked viral RNA signals, whereas the ganglia from all of six patients with elevated antibody titers showed viral RNA signals. Transcription was detected only from the region of the viral genome containing a gene that encodes an immediate early protein known as the infected-cell protein number zero (ICP0). However, normal ("sense") transcripts of this gene, which are prominent in an acute infection, were not detected. In contrast, a novel transcript was found overlapping with, but opposite in direction to, the ICP0 transcript (and was therefore "anti-sense"). Although this transcript has been only partially characterized, we believe that it may have a role in maintaining the latency of herpes simplex virus.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Detection of mRNAs in sea urchin embryos by in situ hybridization using asymmetric RNA probes
Cox, K. H., DeLeon, D. V., Angerer, L. M., & Angerer, R. C. (1984) · Developmental Biology · doi:10.1016/0012-1606(84)90162-3 · Cited by 1,611
Honess, R. W., & Roizman, B. (1974) · Journal of Virology · doi:10.1128/jvi.14.1.8-19.1974 · Cited by 1,414
RNA Complementary to a Herpesvirus α Gene mRNA Is Prominent in Latently Infected Neurons
Stevens, J. G., Wagner, E. K., Devi-Rao, G. B., Cook, M. L., & Feldman, L. T. (1987) · Science · doi:10.1126/science.2434993 · Cited by 899
Infections with Herpes Simplex Viruses
Corey, L., & Spear, P. G. (1986) · New England Journal of Medicine · doi:10.1056/nejm198603133141105 · Cited by 778
Honess, R. W., & Roizman, B. (1975) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.72.4.1276 · Cited by 576
Latent Herpes Simplex Virus in Spinal Ganglia of Mice
Stevens, J. G., & Cook, M. L. (1971) · Science · doi:10.1126/science.173.3999.843 · Cited by 564
CONGENITAL HYDRONEPHROSIS AND HYDRO-URETER WITH CONTRALATERAL PAIN
HUDSON, N. (1949) · The Lancet · doi:10.1016/s0140-6736(49)90266-4 · Cited by 386
Herpesvirus hominis : Isolation from Human Trigeminal Ganglion
Bastian, F. O., Rabson, A. S., Yee, C. L., & Tralka, T. S. (1972) · Science · doi:10.1126/science.178.4058.306 · Cited by 377
Detection of HSV-1 genome in central nervous system of latently infected mice
Rock, D. L., & Fraser, N. W. (1983) · Nature · doi:10.1038/302523a0 · Cited by 331
Recovery of Herpes Simplex Virus from Human Sacral Ganglions
Baringer, J. R. (1974) · New England Journal of Medicine · doi:10.1056/nejm197410172911606 · Cited by 293
Cited by
Specific regulation of gene expression by antisense, sense and antigene nucleic acids
Hélène, C., & Toulmé, J.-J. (1990) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/0167-4781(90)90031-v · Cited by 768
Knickelbein, J. E., Khanna, K. M., Yee, M. B., Baty, C. J., Kinchington, P. R., & Hendricks, R. L. (2008) · Science · doi:10.1126/science.1164164 · Cited by 395
Coen, D. M., Kosz-Vnenchak, M., Jacobson, J. G., Leib, D. A., Bogard, C. L., Schaffer, P. A., Tyler, K. L., & Knipe, D. M. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.12.4736 · Cited by 362
Latent Herpesvirus Infection in Human Trigeminal Ganglia Causes Chronic Immune Response
Theil, D., Derfuss, T., Paripovic, I., Herberger, S., Meinl, E., Schueler, O., Strupp, M., Arbusow, V., & Brandt, T. (2003) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)63575-4 · Cited by 310
Deshmane, S. L., & Fraser, N. W. (1989) · Journal of Virology · doi:10.1128/jvi.63.2.943-947.1989 · Cited by 309
Metadata
- Authors
- Croen, K. D., Ostrove, J. M., Dragovic, L. J., Smialek, J. E., & Straus, S. E.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1987-12-03
- Volume
- 317
- Issue
- 23
- Pages
- 1427-1432
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2337814027
- Cited by
- 320
- References
- 22
- FWCI
- 28.38
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Latent Herpes Simplex Virus in Human Trigeminal Ganglia. https://app.cochat.ai/papers/10.1056/nejm198712033172302
- The paper
- Croen, K. D., Ostrove, J. M., Dragovic, L. J., Smialek, J. E., & Straus, S. E. (1987). Latent Herpes Simplex Virus in Human Trigeminal Ganglia. New England Journal of Medicine. https://doi.org/10.1056/nejm198712033172302
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
