The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Noncytotoxic Lytic Granule–Mediated CD8 + T Cell Inhibition of HSV-1 Reactivation from Neuronal Latency
Open accessAbstract
Reactivation of herpes simplex virus type 1 (HSV-1) from neuronal latency is a common and potentially devastating cause of disease worldwide. CD8 + T cells can completely inhibit HSV reactivation in mice, with interferon-γ affording a portion of this protection. We found that CD8 + T cell lytic granules are also required for the maintenance of neuronal latency both in vivo and in ex vivo ganglia cultures and that their directed release to the junction with neurons in latently infected ganglia did not induce neuronal apoptosis. Here, we describe a nonlethal mechanism of viral inactivation in which the lytic granule component, granzyme B, degrades the HSV-1 immediate early protein, ICP4, which is essential for further viral gene expression.
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Cites
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MicroRNAs expressed by herpes simplex virus 1 during latent infection regulate viral mRNAs
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Virus-Induced Neuronal Apoptosis Blocked by the Herpes Simplex Virus Latency-Associated Transcript
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Chromatin control of herpes simplex virus lytic and latent infection
Knipe, D. M., & Cliffe, A. (2008) · Nature Reviews Microbiology · doi:10.1038/nrmicro1794 · Cited by 444
Khanna, K. M., Bonneau, R. H., Kinchington, P. R., & Hendricks, R. L. (2003) · Immunity · doi:10.1016/s1074-7613(03)00112-2 · Cited by 402
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Self-citationLatent Herpes Simplex Virus in Human Trigeminal Ganglia
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Latent Herpesvirus Infection in Human Trigeminal Ganglia Causes Chronic Immune Response
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Self-citation
Cited by
Gebhardt, T., Wakim, L. M., Eidsmo, L., Reading, P. C., Heath, W. R., & Carbone, F. R. (2009) · Nature Immunology · doi:10.1038/ni.1718 · Cited by 1,157
Tissue-Resident Memory T Cells
Schenkel, J. M., & Masopust, D. (2014) · Immunity · doi:10.1016/j.immuni.2014.12.007 · Cited by 1,059
“Rather than killing these infected neurons and causing immunopathology, granzyme B degrades the immediate early protein ICP4, which is important for viral replication (Knickelbein et al., 2008).”
BackgroundRedefining Chronic Viral Infection
Virgin, H. W., Wherry, E. J., & Ahmed, R. (2009) · Cell · doi:10.1016/j.cell.2009.06.036 · Cited by 1,031
Granzymes in cancer and immunity
Cullen, S. P., Brunet, M., & Martin, S. J. (2010) · Cell Death & Differentiation · doi:10.1038/cdd.2009.206 · Cited by 391
Melanocyte antigen triggers autoimmunity in human psoriasis
Arakawa, A., Siewert, K., Stöhr, J., Besgen, P., Kim, S.-M., Rühl, G., Nickel, J., Vollmer, S., Thomas, P., Krebs, S., et al. (2015) · Journal of Experimental Medicine · doi:10.1084/jem.20151093 · Cited by 361
Metadata
- Authors
- Knickelbein, J. E., Khanna, K. M., Yee, M. B., Baty, C. J., Kinchington, P. R., & Hendricks, R. L.
- Venue
- Science
- Published
- 2008-10-10
- Volume
- 322
- Issue
- 5899
- Pages
- 268-271
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1995796039
- Cited by
- 395
- References
- 24
- FWCI
- 20.37
- Type
- journal article
- Language
- en
- Open access
- green
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- Knickelbein, J. E., Khanna, K. M., Yee, M. B., Baty, C. J., Kinchington, P. R., & Hendricks, R. L. (2008). Noncytotoxic Lytic Granule–Mediated CD8 + T Cell Inhibition of HSV-1 Reactivation from Neuronal Latency. Science. https://doi.org/10.1126/science.1164164
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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