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Preliminary Report: Findings from the Aspirin Component of the Ongoing Physicians' Health Study
Abstract
The Physicians' Health Study is a randomized, double-blind, placebo-controlled trial testing two primary-prevention hypotheses: (1) whether 325 mg of aspirin (as Bufferin, supplied by Bristol-Myers Products) taken every other day reduces mortality from cardiovascular disease, and (2) whether 50 mg of beta carotene (as Lurotin, supplied by BASF) taken on alternate days decreases the incidence of cancer.1 At a special meeting on December 18, 1987, the external Data Monitoring Board of the Physicians' Health Study took the unusual step of recommending the early termination of the randomized aspirin component of the trial, primarily because a statistically extreme beneficial effect on . . .
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Research works printed but not linked: 5
- Hennekens, 1985, Prev Med, 14, 165, 10.1016/0091-7435(85)90031-3 · DOI
- Stampfer, 1985, Stat Med, 4, 111, 10.1002/sim.4780040202 · DOI
- Peto, 1976, Br J Cancer, 34, 585, 10.1038/bjc.1976.220 · DOI · Paper page
- Moncada, 1979, N Engl J Med, 300, 1142, 10.1056/NEJM197905173002006 · doi:10.1056/nejm197905173002006
- Aspirin Myocardial Infarction Study Research Group, 1980, JAMA, 243, 661, 10.1001/jama.1980.03300330019023 · DOI · Paper page
Cited by
Hennekens, C. H., Buring, J. E., Manson, J. E., Stampfer, M., Rosner, B., Cook, N. R., Belanger, C., LaMotte, F., Gaziano, J. M., Ridker, P. M., et al. (1996) · New England Journal of Medicine · doi:10.1056/nejm199605023341801 · Cited by 2,397
Meta-Analysis: Recent Developments in Quantitative Methods for Literature Reviews
Rosenthal, R., & DiMatteo, M. R. (2001) · Annual Review of Psychology · doi:10.1146/annurev.psych.52.1.59 · Cited by 1,780
Is caregiving hazardous to one’s physical health? A meta-analysis
Vitaliano, P. P., Zhang, J., & Scanlan, J. M. (2003) · Psychological Bulletin · doi:10.1037/0033-2909.129.6.946 · Cited by 1,734
Standards of Evidence: Criteria for Efficacy, Effectiveness and Dissemination
Flay, B. R., Biglan, A., Boruch, R. F., Castro, F. G., Gottfredson, D., Kellam, S., Mościcki, E. K., Schinke, S., Valentine, J. C., & Ji, P. (2005) · Prevention Science · doi:10.1007/s11121-005-5553-y · Cited by 1,338
Blood Levels of Long-Chain n–3 Fatty Acids and the Risk of Sudden Death
Albert, C. M., Campos, H., Stampfer, M. J., Ridker, P. M., Manson, J. E., Willett, W. C., & Ma, J. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa012918 · Cited by 1,146
Metadata
- Authors
- The Steering Committee of the Physicians' Health Study Research Group
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1988-01-28
- Volume
- 318
- Issue
- 4
- Pages
- 262-264
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W4242263299
- Cited by
- 520
- References
- 0
- FWCI
- 51.80
- Type
- journal article
- Language
- en
- Open access
- closed
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- The Steering Committee of the Physicians' Health Study Research Group. (1988). Preliminary Report: Findings from the Aspirin Component of the Ongoing Physicians' Health Study. New England Journal of Medicine. https://doi.org/10.1056/nejm198801283180431
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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