Blood Levels of Long-Chain n–3 Fatty Acids and the Risk of Sudden Death
Open accessAbstract
BACKGROUND: Experimental data suggest that long-chain n-3 polyunsaturated fatty acids found in fish have antiarrhythmic properties, and a randomized trial suggested that dietary supplements of n-3 fatty acids may reduce the risk of sudden death among survivors of myocardial infarction. Whether long-chain n-3 fatty acids are also associated with the risk of sudden death in those without a history of cardiovascular disease is unknown. METHODS: We conducted a prospective, nested case-control analysis among apparently healthy men who were followed for up to 17 years in the Physicians' Health Study. The fatty-acid composition of previously collected blood was analyzed by gas-liquid chromatography for 94 men in whom sudden death occurred as the first manifestation of cardiovascular disease and for 184 controls matched with them for age and smoking status. RESULTS: Base-line blood levels of long-chain n-3 fatty acids were inversely related to the risk of sudden death both before adjustment for potential confounders (P for trend = 0.004) and after such adjustment (P for trend = 0.007). As compared with men whose blood levels of long-chain n-3 fatty acids were in the lowest quartile, the relative risk of sudden death was significantly lower among men with levels in the third quartile (adjusted relative risk, 0.28; 95 percent confidence interval, 0.09 to 0.87) and the fourth quartile (adjusted relative risk, 0.19; 95 percent confidence interval, 0.05 to 0.71). CONCLUSIONS: The n-3 fatty acids found in fish are strongly associated with a reduced risk of sudden death among men without evidence of prior cardiovascular disease.
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Blood levels of n-3 LCPUFA, particularly EPA and DHA, have been linked to a reduced risk of primary cardiac arrest, sudden cardiac death, and all cause dementia.
“Blood levels of n-3 LCPUFA, particularly EPA and DHA, have been linked to a reduced risk of primary cardiac arrest [22], sudden cardiac death [23], and all cause dementia [24].”
From Role of n-3 long-chain polyunsaturated fatty acids in human nutrition and health: Review of recent studies and recommendations (2021) · cites this paper as [23]
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- Authors
- Albert, C. M., Campos, H., Stampfer, M. J., Ridker, P. M., Manson, J. E., Willett, W. C., & Ma, J.
- Affiliations
- Brigham and Women's Hospital (US)
- Harvard University (US)
- ORCID
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2002-04-11
- Volume
- 346
- Issue
- 15
- Pages
- 1113-1118
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2014226775
- Cited by
- 1,146
- References
- 26
- Citations by year
- 2026: 11 · 2025: 10 · 2024: 13 · 2023: 12 · 2022: 15 · 2021: 20 · 2020: 26 · 2019: 26 · 2018: 33 · 2017: 27 · 2016: 33 · 2015: 40 · 2014: 58 · 2013: 67 · 2012: 74
- FWCI
- 74.19
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (HL-34595, CA-40360, HL 26490, CA-34944, R01HL034595, K08HL003783, 1-K08-HL-03783)
- National Cancer Institute (R01CA040360, CA 34944, CA 40360)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Keywords
- n-3 long-chain polyunsaturated fatty acids, omega-3 polyunsaturated fatty acids, sudden death, cardiovascular mortality, blood fatty acid levels, fish consumption, antiarrhythmic effect, Physicians' Health Study
- MeSH terms
- Adult, Aged, Aged, 80 and over, Alcohol Drinking, Fatty Acids, Fish Oils, Humans, Male, Middle Aged, Prospective Studies, Risk, Risk Factors, Fatty Acids, Omega-3, Multivariate Analysis, Case-Control Studies, Death, Sudden, Cardiac
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