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Cited by 328

The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.

Colchicine in the Treatment of Cirrhosis of the Liver

Kershenobich, David, Vargas, Florencia, Garcia-Tsao, Guadalupe, Tamayo, Ruy Perez, Gent, Michael, Rojkind, Marcos·1988·New England Journal of Medicine
DOI 10.1056/nejm198806303182602
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Abstract

There is preliminary evidence that colchicine, an inhibitor of collagen synthesis, may be beneficial in the treatment of cirrhosis of the liver. To evaluate the use of colchicine (1 mg per day, five days per week) in the treatment of hepatic cirrhosis, we performed a randomized, double-blind, placebo-controlled trial in which 100 patients were followed for up to 14 years. Forty-five patients had alcoholic cirrhosis, 41 had posthepatitic cirrhosis, and the remaining 14 had cirrhosis with various other causes. Histologic studies were available for 92 percent of patients. Seventy-three patients were in Child-Turcotte class A, 26 were in class B, and one was in class C. Fifty-four patients received colchicine, and 46 received placebo. The overall survival in the colchicine group was markedly better than in the placebo group (median survival, 11 and 3.5 years, respectively; P less than 0.001). The cumulative 5-year survival rates were 75 percent in the colchicine group and 34 percent in the placebo group; the corresponding 10-year survival rates were 56 percent and 20 percent. Among the 30 patients treated with colchicine who underwent repeated liver biopsies, histologic improvement was seen in 9; the liver appeared normal in 2, and 7 had minimal portal fibrosis. No histologic improvement was observed in the 14 members of the placebo group who had two or more biopsies. Few side effects were observed in either group.

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Metadata

Authors
Kershenobich, D., Vargas, F., Garcia-Tsao, G., Tamayo, R. P., Gent, M., & Rojkind, M.
Venue
New England Journal of Medicine
Publisher
Massachusetts Medical Society
Published
1988-06-30
Volume
318
Issue
26
Pages
1709-1713
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
DOI
10.1056/nejm198806303182602
OpenAlex
W2325156742
Cited by
328
References
20
FWCI
20.85
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Colchicine in the Treatment of Cirrhosis of the Liver. https://app.cochat.ai/papers/10.1056/nejm198806303182602
The paper
Kershenobich, D., Vargas, F., Garcia-Tsao, G., Tamayo, R. P., Gent, M., & Rojkind, M. (1988). Colchicine in the Treatment of Cirrhosis of the Liver. New England Journal of Medicine. https://doi.org/10.1056/nejm198806303182602

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.