The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Indomethacin in the Treatment of Premature Labor
Abstract
Indomethacin is a potent agent in the treatment of premature labor, but its use has been limited because of concern about its constrictive effects on the fetal ductus arteriosus. To study these effects we used serial fetal echocardiography in 13 pregnant women in premature labor who received indomethacin according to three different dose schedules, ranging from 100 to 175 mg per day, for a maximum of 72 hours. The gestational ages of the fetuses ranged from 26.5 to 31.0 weeks. The detection of ductal constriction in 7 of the 14 fetuses by echocardiography led to the discontinuation of indomethacin. Three fetuses also had tricuspid regurgitation. There was no statistically significant difference between the mean (+/- SEM) gestational age of the fetuses with ductal constriction and that of those without constriction (29.3 +/- 0.59 and 28.4 +/- 0.52, respectively). There was no relation between serum indomethacin levels in the mothers and ductal constriction. In all seven fetuses affected, ductal constriction had resolved by the time they were restudied 24 hours after the discontinuation of indomethacin. Persistent fetal circulation was not detected in any of the 11 neonates studied after delivery. Indomethacin used to treat premature labor appears to cause transient constriction of the ductus arteriosus in some fetuses, even after short-term use.
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Cites
TOXIC-SHOCK SYNDROME NOT ASSOCIATED WITH MENSTRUATION
Reingold, A., Shands, K., Dan, B., & Broome, C. (1982) · The Lancet · doi:10.1016/s0140-6736(82)92552-1 · Cited by 1,164
The women and their pregnancies
Drogendijk, A. C. (1973) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/0028-2243(73)90060-9 · Cited by 585
Obstetric Complications Associated with the Lupus Anticoagulant
Branch, D. W., Scott, J. R., Kochenour, N. K., & Hershgold, E. (1985) · New England Journal of Medicine · doi:10.1056/nejm198511213132104 · Cited by 560
Wallenburg, H. C. S., Makovitz, J. W., Dekker, G. A., & Rotmans, P. (1986) · The Lancet · doi:10.1016/s0140-6736(86)91891-x · Cited by 542
INHIBITION OF HUMAN PREMATURE LABOR BY INDOMETHACIN
ZUCKERMAN, H., REISS, U., & RUBINSTEIN, I. (1975) · Obstetrical & Gynecological Survey · doi:10.1097/00006254-197505000-00009 · Cited by 261
The inhibition of premature labor with indomethacin
Niebyl, J. R., Blake, D. A., White, R. D., Kumor, K. M., Dubin, N. H., Robinson, J. C., & Egner, P. G. (1980) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(80)90629-8 · Cited by 208
Huhta, J. C., Moise, K. J., Fisher, D. J., Sharif, D. S., Wasserstrum, N., & Martin, C. (1987) · Circulation · doi:10.1161/01.cir.75.2.406 · Cited by 184
Self-citationNeonatal outcome after indomethacin treatment for preterm labor
Niebyl, J. R., & Witter, F. R. (1986) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(86)80012-6 · Cited by 117
Fetal and neonatal effects of indomethacin used as a tocolytic agent
Dudley, D. K. L., & Hardie, M. J. (1985) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(85)90008-0 · Cited by 109
Fuchs, F. (1976) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(76)90670-0 · Cited by 77
Cited by
Donofrio, M. T., Moon-Grady, A. J., Hornberger, L. K., Copel, J. A., Sklansky, M. S., Abuhamad, A., Cuneo, B. F., Huhta, J. C., Jonas, R. A., Krishnan, A., et al. (2014) · Circulation · doi:10.1161/01.cir.0000437597.44550.5d · Cited by 1,275
Self-citationNeonatal complications after the administration of indomethacin for preterm labor
Norton, M. E., Merrill, J., Cooper, B., Kuller, J. A., & Clyman, R. I. (1993) · New England Journal of Medicine · doi:10.1056/nejm199311253292202 · Cited by 438
The prostaglandin receptor EP4 triggers remodelling of the cardiovascular system at birth
Nguyen, M., Camenisch, T., Snouwaert, J. N., Hicks, E., Coffman, T. M., Anderson, P. A. W., Malouf, N. N., & Koller, B. H. (1997) · Nature · doi:10.1038/36342 · Cited by 363
Metaanalysis of the effect of antenatal indomethacin on neonatal outcomes
Amin, S. B., Sinkin, R. A., & Glantz, J. C. (2007) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2007.04.019 · Cited by 78
Loftin, C. D., Trivedi, D. B., & Langenbach, R. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0214924 · Cited by 65
Metadata
- Authors
- Moise, K. J., Huhta, J. C., Sharif, D. S., Ou, C.-N., Kirshon, B., Wasserstrum, N., & Cano, L.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1988-08-11
- Volume
- 319
- Issue
- 6
- Pages
- 327-331
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2317472642
- Cited by
- 359
- References
- 10
- FWCI
- 14.79
- Type
- journal article
- Language
- en
- Open access
- closed
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- Moise, K. J., Huhta, J. C., Sharif, D. S., Ou, C.-N., Kirshon, B., Wasserstrum, N., & Cano, L. (1988). Indomethacin in the Treatment of Premature Labor. New England Journal of Medicine. https://doi.org/10.1056/nejm198808113190602
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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