The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Obstetric Complications Associated with the Lupus Anticoagulant
Abstract
We identified eight patients with the lupus anticoagulant (an autoantibody acquired by some patients with systemic lupus erythematosus), by observation of an increased activated partial thromboplastin time and abnormal results on a tissue thromboplastin-inhibition test. The patients had experienced a total of 30 spontaneous abortions and fetal deaths in 31 previous pregnancies (96.8 per cent). During their next pregnancy, the patients were treated with 40 to 50 mg of prednisone per day and 81 mg of aspirin per day. The therapy shortened their activated partial thromboplastin times, produced normal values for tissue thromboplastin inhibition, and reduced the rate of pregnancy loss to 37.5 per cent. However, preeclampsia developed in the five patients who gave birth to live infants, and fetal growth retardation occurred in three cases. The corticosteroid and low-dose aspirin regimen appears to improve perinatal outcome in cases in which the mother has the lupus anticoagulant, but such practices as careful fetal surveillance and preterm delivery when appropriate are also important to successful obstetric management of such cases.
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Cites
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Preeclampsia: An imbalance in placental prostacyclin and thromboxane Production
Walsh, S. W. (1985) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(85)80223-4 · Cited by 601
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Thrombosis in Patients with the Lupus Anticoagulant
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Cited by
Antiphospholipid thrombosis: clinical course after the first thrombotic event in 70 patients
Rosove, M. H., & Brewer, P. M. C. (1992) · Annals of Internal Medicine · doi:10.7326/0003-4819-117-4-303 · Cited by 700
Detection of At-Risk Pregnancy by Means of Highly Sensitive Assays for Thyroid Autoantibodies
Stagnaro-Green, A. (1990) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1990.03450110068029 · Cited by 494
Immunology and clinical importance of antiphospholipid antibodies
McNeil, H. P., Chesterman, C. N., & Krilis, S. A. (1991) · Advances in immunology · doi:10.1016/s0065-2776(08)60777-4 · Cited by 481
Indomethacin in the Treatment of Premature Labor
Moise, K. J., Huhta, J. C., Sharif, D. S., Ou, C.-N., Kirshon, B., Wasserstrum, N., & Cano, L. (1988) · New England Journal of Medicine · doi:10.1056/nejm198808113190602 · Cited by 359
Prevalence, Follow-Up and Clinical Significance of the Anticardiolipin Antibodies in Normal Subjects
Vila, P., Hernández, M. C., López-Fernández, M. F., & Batlle, J. (1994) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1648840 · Cited by 280
Metadata
- Authors
- Branch, D. W., Scott, J. R., Kochenour, N. K., & Hershgold, E.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1985-11-21
- Volume
- 313
- Issue
- 21
- Pages
- 1322-1326
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2340551875
- Cited by
- 560
- References
- 32
- FWCI
- 25.70
- Type
- journal article
- Language
- en
- Open access
- closed
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- Branch, D. W., Scott, J. R., Kochenour, N. K., & Hershgold, E. (1985). Obstetric Complications Associated with the Lupus Anticoagulant. New England Journal of Medicine. https://doi.org/10.1056/nejm198511213132104
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
