The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Difference between Endothelium-Dependent Relaxation in Arterial and in Venous Coronary Bypass Grafts
Abstract
Both the internal mammary artery and the saphenous vein are used to construct coronary-artery bypass grafts. We hypothesized that the release or production of endothelium-derived relaxing factor, which regulates blood flow and inhibits platelet function, may differ in venous and arterial grafts. We therefore studied endothelium-dependent relaxation in internal mammary arteries, internal mammary veins, and saphenous veins obtained from 58 patients undergoing coronary bypass surgery. Vascular rings with and without endothelium were suspended in organ chambers, and isometric tension was recorded. Acetylcholine (10(-8) to 10(-4) M), thrombin (1 U per milliliter), and adenosine diphosphate (10(-7) to 10(-4) M) evoked potent endothelium-dependent relaxation in the mammary artery but weak response in the saphenous vein (P less than 0.005; n = 6 to 27). In the mammary artery, relaxation was greatest in response to acetylcholine (86 +/- 4 percent reduction in norepinephrine-induced tension), followed by thrombin (44 +/- 7 percent) and adenosine diphosphate (39 +/- 8 percent). In the saphenous and mammary veins, relaxation was less than 25 percent. Relaxation was unaffected by indomethacin but was inhibited by methylene blue and hemoglobin (P less than 0.005 and 0.01, respectively), which suggests that endothelium-derived relaxing factor was the mediator. Endothelium-independent relaxation in response to sodium nitroprusside was similar in arteries and veins. We conclude that endothelium-dependent relaxation is greater in the mammary artery than in the saphenous vein. The possibility that this contributes to the higher patency rate among arterial grafts than among venous grafts will require further study.
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Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor
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Influence of the Internal-Mammary-Artery Graft on 10-Year Survival and Other Cardiac Events
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ENDOGENOUS NITRIC OXIDE INHIBITS HUMAN PLATELET ADHESION TO VASCULAR ENDOTHELIUM
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The L-Arginine-Nitric Oxide Pathway
Epstein, F. H., Moncada, S., & Higgs, A. (1993) · New England Journal of Medicine · doi:10.1056/nejm199312303292706 · Cited by 6,678
2011 ACCF/AHA Guideline for Coronary Artery Bypass Graft Surgery
Hillis, L. D., Smith, P. K., Anderson, J. L., Bittl, J. A., Bridges, C. R., Byrne, J. G., Cigarroa, J. E., DiSesa, V. J., Hiratzka, L. F., Hutter, A. M., et al. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2011.08.009 · Cited by 820
NITRIC OXIDE SYNTHASE: Role in the Genesis of Vascular Disease
Cooke, M., & Dzau, M. (1997) · Annual Review of Medicine · doi:10.1146/annurev.med.48.1.489 · Cited by 710
Lauer, T., Preik, M., Rassaf, T., Strauer, B. E., Deussen, A., Feelisch, M., & Kelm, M. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.221381098 · Cited by 585
Modulation of Prostaglandin Biosynthesis by Nitric Oxide and Nitric Oxide Donors
Mollace, V., Muscoli, C., Masini, E., Cuzzocrea, S., & Salvemini, D. (2005) · Pharmacological Reviews · doi:10.1124/pr.57.2.1 · Cited by 357
Metadata
- Authors
- Lüscher, T. F., Diederich, D., Siebenmann, R., Lehmann, K., Stulz, P., Segesser, L. V., Yang, Z., Turina, M., Grädel, E., Weber, E., & Bühler, F. R.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1988-08-25
- Volume
- 319
- Issue
- 8
- Pages
- 462-467
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2337043297
- Cited by
- 533
- References
- 26
- FWCI
- 13.71
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lüscher, T. F., Diederich, D., Siebenmann, R., Lehmann, K., Stulz, P., Segesser, L. V., Yang, Z., Turina, M., Grädel, E., Weber, E., & Bühler, F. R. (1988). Difference between Endothelium-Dependent Relaxation in Arterial and in Venous Coronary Bypass Grafts. New England Journal of Medicine. https://doi.org/10.1056/nejm198808253190802
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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