The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
A Case–Control Study of Chorioamnionic Infection and Histologic Chorioamnionitis in Prematurity
Abstract
To study the role of infection in prematurity, we studied the demographic and obstetrical characteristics, chorioamnionic cultures, and placental histologic features of women who delivered prematurely and compared these findings with those in women who delivered at term. Microorganisms were isolated from the area between the chorion and the amnion (chorioamnion) in 23 of 38 placentas (61 percent) from women with preterm labor who delivered before 37 weeks' gestation and in 12 (21 percent) of 56 placentas from women without preterm labor who delivered at term (odds ratio, 5.6; 95 percent confidence interval, 2.1 to 15.6). The most frequent isolates from the placentas of those whose infants were delivered prematurely were Ureaplasma urealyticum (47 percent) and Gardnerella vaginalis (26 percent). The recovery of any organism from the chorioamnion was strongly associated with histologic chorioamnionitis (odds ratio, 7.2; 95 percent confidence interval, 2.7 to 19.5) and with bacterial vaginosis (odds ratio, 3.2; 95 percent confidence interval, 1.1 to 6.6). When multiple logistic regression was used to control for demographic and obstetrical variables, premature delivery was still related to the recovery of organisms from the chorioamnion (odds ratio, 3.8; 95 percent confidence interval, 1.5 to 9.9) and with chorioamnionitis (odds ratio, 5.0; 95 percent confidence interval, 1.6 to 15.3). The proportion of placentas with evidence of infection was highest among those who delivered at the lowest gestational age. We conclude that infection of the chorioamnion is strongly related to histologic chorioamnionitis and may be a cause of premature birth.
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Cites
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Self-citationPreterm Labor Associated With Subclinical Amniotic Fluid Infection and With Bacterial Vaginosis
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Self-citationEtiology of Nongonococcal Urethritis
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Self-citationDiagnosis of bacterial vaginosis by direct gram stain of vaginal fluid
Spiegel, C. A., Amsel, R., & Holmes, K. K. (1983) · Journal of Clinical Microbiology · doi:10.1128/jcm.18.1.170-177.1983 · Cited by 412
Self-citationTrichomonas vaginalis: Reevaluation of Its Clinical Presentation and Laboratory Diagnosis
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Cited by
Intrauterine infection and preterm delivery
Goldenberg, R. L., Hauth, J. C., & Andrews, W. W. (2000) · New England Journal of Medicine · doi:10.1056/nejm200005183422007 · Cited by 2,548
Milani, C., Duranti, S., Bottacini, F., Casey, E., Turroni, F., Mahony, J., Belzer, C., Delgado Palacio, S., Arboleya Montes, S., Mancabelli, L., et al. (2017) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00036-17 · Cited by 1,950
Association between Bacterial Vaginosis and Preterm Delivery of a Low-Birth-Weight Infant
Hillier, S. L., Nugent, R. P., Eschenbach, D. A., Krohn, M. A., Gibbs, R. S., Martin, D. H., Cotch, M. F., Edelman, R., Pastorek, J. G., Rao, A. V., et al. (1995) · New England Journal of Medicine · doi:10.1056/nejm199512283332604 · Cited by 1,492
Self-citationPeriodontal infection as a possible risk factor for preterm low birth weight
Offenbacher, S., Katz, V., Fertik, G., Collins, J., Boyd, D., Maynor, G., McKaig, R., & Beck, J. (1996) · Journal of Periodontology · doi:10.1902/jop.1996.67.10s.1103 · Cited by 1,455
Practice Bulletin No. 183: postpartum hemorrhage
(2017) · Obstetrics & Gynecology · doi:10.1097/aog.0000000000002351 · Cited by 1,406
Metadata
- Authors
- Hillier, S. L., Martius, J., Krohn, M., Kiviat, N., Holmes, K. K., & Eschenbach, D. A.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1988-10-13
- Volume
- 319
- Issue
- 15
- Pages
- 972-978
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2339073512
- Cited by
- 992
- References
- 27
- FWCI
- 19.13
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hillier, S. L., Martius, J., Krohn, M., Kiviat, N., Holmes, K. K., & Eschenbach, D. A. (1988). A Case–Control Study of Chorioamnionic Infection and Histologic Chorioamnionitis in Prematurity. New England Journal of Medicine. https://doi.org/10.1056/nejm198810133191503
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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