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Cited by 601Obsessive-Compulsive Spectrum DisordersAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesPsychoanalysis and Psychopathology Research

The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.

A Double-Blind Comparison of Clomipramine and Desipramine in the Treatment of Trichotillomania (Hair Pulling)

Swedo, Susan E., Leonard, Henrietta L., Rapoport, Judith L., Lenane, Marge C., Goldberger, Erica L., Cheslow, Deborah L.·1989·New England Journal of Medicine
DOI 10.1056/nejm198908243210803
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Abstract

Trichotillomania, an irresistible impulse to pull out one's own hair, is a chronic psychiatric illness that causes severe discomfort, interferes with daily activities, and leads to social isolation. Treatment is usually unsatisfactory. Thirteen women with severe trichotillomania completed a 10-week double-blind, crossover trial of clomipramine, a new tricyclic antidepressant agent with selective antiobsessional effects, and desipramine, a standard tricyclic antidepressant. Treatment with clomipramine resulted in significantly greater improvement in symptoms than desipramine, as indicated by physicians' ratings of the women's clinical progress on a scale in which lower scores indicate improvement (mean [+/- SD] scores: at base line, 10.0; after desipramine treatment, 8.7 +/- 2.4; after clomipramine treatment, 4.7 +/- 3.1; P = 0.006) and by scores on a trichotillomania-impairment scale, in which higher scores indicate greater impairment (at base line, 6.8 +/- 1.7; after desipramine treatment, 6.2 +/- 1.7; after clomipramine treatment, 4.2 +/- 2.7; P = 0.03). The severity of symptoms (mean base-line score, 15.9 +/- 3.8) was reduced more by clomipramine (10.6 +/- 6.4) than by desipramine (14.4 +/- 3.9). The patients reported that the compulsion decreased in intensity and that they were more able to resist the urge to pull out their hair during treatment with clomipramine. We conclude that clomipramine appears to be effective in the short-term treatment of trichotillomania.

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Crossref · 10.1056/nejm198908243210803

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Show all 31 references

Research works printed but not linked: 9

  1. Hallopeau, 1889, Ann Dermatol Venereol, 10, 440
  2. Jillson, 1983, Cutis, 31, 383
  3. Sorosky, 1980, Adolesc Psychiatry, 8, 437
  4. Galski, 1983, Psychoanal Rev, 70, 331
  5. Childers, 1958, J Clin Exp Psychopathol, 19, 141
  6. Krishnan, 1984, J Clin Psychiatry, 45, 267
  7. Sachdeva, 1987, J Indian Med Assoc, 85, 151
  8. Montgomery, 1980, Pharm Med, 1, 189
  9. Murphy DL, Pickar D, Alterman IS. Methods for the quantitative assessment of depressive and manic behavior. In: Burdock EL, Sudilovsky A, Gershon S, eds. The behavior of psychiatric patients: quantitative techniques for evaluation. Experimental and clinical psychiatry. Vol. 7. New York: Marcel Dekker, 1982:355–92.

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Metadata

Authors
Swedo, S. E., Leonard, H. L., Rapoport, J. L., Lenane, M. C., Goldberger, E. L., & Cheslow, D. L.
Affiliations
National Institute of Mental Health (US)
ORCID
Swedo, Susan E.
Venue
New England Journal of Medicine
Publisher
Massachusetts Medical Society
Published
1989-08-24
Volume
321
Issue
8
Pages
497-501
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
DOI
10.1056/nejm198908243210803
OpenAlex
W2325821938
Cited by
601
References
31
Citations by year
2026: 10 · 2025: 6 · 2024: 8 · 2023: 32 · 2022: 7 · 2021: 13 · 2020: 4 · 2019: 10 · 2018: 20 · 2017: 11 · 2016: 12 · 2015: 16 · 2014: 14 · 2013: 9 · 2012: 45
FWCI
35.31
Type
journal article
Language
en
Open access
closed
Locations
  • New England Journal of Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
  • Social Sciences › Psychology › Clinical Psychology › Psychoanalysis and Psychopathology Research
Keywords
trichotillomania, clomipramine, desipramine, tricyclic antidepressants, compulsive hair pulling, obsessive-compulsive symptoms, treatment efficacy, women
MeSH terms
Adolescent, Adult, Clomipramine, Desipramine, Double-Blind Method, Female, Humans, Obsessive-Compulsive Disorder, Trichotillomania

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