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Suppression of in vitro Epstein-Barr virus infection. A new role for adult human T lymphocytes.
Open accessAbstract
Studies have been performed on in vitro infection by Epstein-Barr virus (EBV) of subpopulations of human lymphocytes. B cells of adult peripheral or fetal cord blood transform with equal efficiency, whether assayed by DNA synthesis induction or by outgrowth of transformed lymphocytes. In contrast, unfractionated adult lymphocytes transform much less efficiently than those from fetal cord. Reconstitution experiments of different cell preparations indicated that this difference was due to a suppression of B-cell proliferation by adult Ig-negative lymphocytes which fetal Ig-negative lymphocytes were unable to perform. Separation of Ig-negative lymphocytes into various subpopulations revealed that the suppression was performed by T cells. Macrophages and null cells play little or no role in suppression. The relevance of this phenomenon to infection and recovery from EBV infection during and after infectious mononucleosis is discussed.
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Cited by
MADDON, P., LITTMAN, D., GODFREY, M., MADDON, D., CHESS, L., & AXEL, R. (1985) · Cell · doi:10.1016/s0092-8674(85)80105-7 · Cited by 658
Self-citationSecondary Cancers after Bone Marrow Transplantation for Leukemia or Aplastic Anemia
Witherspoon, R. P., Fisher, L. D., Schoch, G., Martin, P., Sullivan, K. M., Sanders, J., Deeg, H. J., Doney, K., Thomas, D., Storb, R., et al. (1989) · New England Journal of Medicine · doi:10.1056/nejm198909213211203 · Cited by 409
Shaw, S., Johnson, A. H., & Shearer, G. M. (1980) · The Journal of experimental medicine · doi:10.1084/jem.152.3.565 · Cited by 346
NK Cell Compartments and Their Activation by Dendritic Cells
Ferlazzo, G., & Münz, C. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.3.1333 · Cited by 299
T cell reactivity to penicillin: phenotypic analysis of in vitro activated cell subsets
Koponen, M., Pichler, W. J., & de Weck, A. L. (1986) · Journal of Allergy and Clinical Immunology · doi:10.1016/0091-6749(86)90083-7 · Cited by 57
Metadata
- Authors
- Thorley-Lawson, D. A., Chess, L., & Strominger, J. L.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1977-08-01
- Volume
- 146
- Issue
- 2
- Pages
- 495-508
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2140212557
- Cited by
- 206
- References
- 0
- FWCI
- 9.60
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Thorley-Lawson, D. A., Chess, L., & Strominger, J. L. (1977). Suppression of in vitro Epstein-Barr virus infection. A new role for adult human T lymphocytes. The Journal of experimental medicine. https://doi.org/10.1084/jem.146.2.495
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
