Cited by 1,547Lipoproteins and Cardiovascular HealthCholesterol and Lipid MetabolismParaoxonase enzyme and polymorphisms

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High-Density Lipoprotein — The Clinical Implications of Recent Studies

Desforges, Jane F., Gordon, David J., Rifkind, Basil M.·1989·New England Journal of Medicine

DOI 10.1056/nejm198911093211907

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Abstract

DESPITE early observations suggesting an inverse relation between serum levels of high-density lipoprotein (HDL) cholesterol and coronary disease,1 2 3 the possible protective role of HDL in atherogenesis received little attention until its "rediscovery" by Miller and Miller4 in 1975 and the publication of confirmatory results from the Honolulu,5 Framingham,6 and Tromsø7 heart studies in 1976 and 1977. In the ensuing decade, research into the biochemistry, metabolism, epidemiology, and genetics of HDL has expanded rapidly, but many questions remain unanswered. The recent publication of the results of the Helsinki Heart Study8 , 9 — in which simultaneous 11 percent increases in HDL and reductions . . .

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Sorted by citations

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Gemfibrozil for the Secondary Prevention of Coronary Heart Disease in Men with Low Levels of High-Density Lipoprotein Cholesterol
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“026 mmol/l) decrease in HDL cholesterol.(56) A causal relation between changes in HDL cholesterol and changes in risk is credible but not proven.”
Background

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Authors: Desforges, J. F., Gordon, D. J., & Rifkind, B. M.
Affiliations: National Heart, Lung, and Blood Institute (US)
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 1989-11-09
Volume: 321
Issue: 19
Pages: 1311-1316
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejm198911093211907
OpenAlex: W2339616051
Cited by: 1,547
References: 50
Citations by year: 2026: 9 · 2025: 6 · 2024: 15 · 2023: 19 · 2022: 13 · 2021: 22 · 2020: 22 · 2019: 30 · 2018: 21 · 2017: 24 · 2016: 36 · 2015: 47 · 2014: 42 · 2013: 42 · 2012: 38
FWCI: 9.17
Type: journal article
Language: en
Open access: closed
Locations: New England Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Paraoxonase enzyme and polymorphisms
Keywords: high-density lipoprotein, HDL cholesterol, coronary artery disease, atherogenesis, cardioprotection, HDL metabolism, Helsinki Heart Study
MeSH terms: Coronary Disease, Humans, Lipoproteins, HDL, Cholesterol, HDL

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High-Density Lipoprotein — The Clinical Implications of Recent Studies

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