The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Gastrinomas in the Duodenums of Patients with Multiple Endocrine Neoplasia Type 1 and the Zollinger-Ellison Syndrome
Open accessAbstract
In patients with multiple endocrine neoplasia type 1 (MEN-1), gastrinomas are common and thought to occur predominantly in the pancreas. We describe eight patients with MEN-1 and hypergastrinemia (seven with the Zollinger-Ellison syndrome) in whom we searched for neuroendocrine tumors in the pancreas and duodenum. Tumors were found in the proximal duodenum in all eight patients: solitary tumors (diameter, 6 to 20 mm) in three patients and multiple microtumors (diameter, 2 to 6 mm) in the other five. Paraduodenal lymph-node metastases were detected in four patients. Immunocytochemical analysis revealed the presence of gastrin in all the duodenal tumors and in their lymph-node metastases. In contrast, no immunoreactivity for gastrin was present in the endocrine tumors found in the seven pancreatic specimens available for study, except for one tumor with scattered gastrin-positive cells. In four of the six patients whose duodenal gastrinomas were removed, serum gastrin levels returned to normal; in the other two patients gastrin concentrations decreased toward normal. We conclude that in patients with MEN-1 and the Zollinger-Ellison syndrome, gastrinomas occur in the duodenum, but the tumors may be so small that they escape detection.
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Citations
Cites
FAMILIAL MULTIPLE ENDOCRINE ADENOMA-PEPTIC ULCER COMPLEX
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Zollinger–Ellison Syndrome: Current Concepts in Diagnosis and Management
Wolfe, M. M., & Jensen, R. T. (1987) · New England Journal of Medicine · doi:10.1056/nejm198711053171907 · Cited by 233
Pathomorphologic, biochemical, and diagnostic aspects of gastrinomas (Zollinger-Ellison syndrome)
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Familial Multiple Endocrine Neoplasia Type I: A New Look at Pathophysiology
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Self-citationMEN I pancreas: A histological and immunohistochemical study
Thompson, N. W., Lloyd, R. V., Nishiyama, R. H., Vinik, A. I., Strodel, W. E., Allo, M. D., Eckhauser, F. E., Talpos, G., & Mervak, T. (1984) · World Journal of Surgery · doi:10.1007/bf01654938 · Cited by 162
Medical and surgical options in the management of patients with gastrinoma
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Duodenal and ampullary carcinoid tumors
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Self-citationResults of Surgical Management in 92 Consecutive Patients with Zollinger-Ellison Syndrome
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Outcome of Lymph Node Involvement in Patients with the Zollinger-Ellison Syndrome
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Cited by
The diagnosis and medical management of advanced neuroendocrine tumors.
Kaltsas, G. A., Besser, G. M., & Grossman, A. B. (2004) · Endocrine Reviews · doi:10.1210/er.2003-0014 · Cited by 674
Gibril, F., Schumann, M., Pace, A., & Jensen, R. T. (2004) · Medicine · doi:10.1097/01.md.0000112297.72510.32 · Cited by 313
Anlauf, M., Schlenger, R., Perren, A., Bauersfeld, J., Koch, C. A., Dralle, H., Raffel, A., Knoefel, W. T., Weihe, E., Ruszniewski, P., et al. (2006) · American Journal of Surgical Pathology · doi:10.1097/01.pas.0000194044.01104.25 · Cited by 223
Self-citationWell-differentiated pancreatic neuroendocrine tumors: from genetics to therapy
de Wilde, R. F., Edil, B. H., Hruban, R. H., & Maitra, A. (2012) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2012.9 · Cited by 122
Metadata
- Authors
- Pipeleers-Marichal, M., Somers, G., Willems, G., Foulis, A., Imrie, C., Bishop, A. E., Polak, J. M., Häcki, W. H., Stamm, B., Heitz, P. U., & Klöppel, G.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1990-03-15
- Volume
- 322
- Issue
- 11
- Pages
- 723-727
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2320542643
- Cited by
- 396
- References
- 16
- FWCI
- 12.24
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Pipeleers-Marichal, M., Somers, G., Willems, G., Foulis, A., Imrie, C., Bishop, A. E., Polak, J. M., Häcki, W. H., Stamm, B., Heitz, P. U., & Klöppel, G. (1990). Gastrinomas in the Duodenums of Patients with Multiple Endocrine Neoplasia Type 1 and the Zollinger-Ellison Syndrome. New England Journal of Medicine. https://doi.org/10.1056/nejm199003153221103
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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