The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Pulmonary Aspergillosis in the Acquired Immunodeficiency Syndrome
Open accessAbstract
BACKGROUND AND METHODS: Symptomatic pulmonary aspergillosis has rarely been reported in patients with the acquired immunodeficiency syndrome (AIDS). We describe the predisposing factors, the clinical and radiologic features, and the therapeutic outcomes in 13 patients with pulmonary aspergillosis, all of whom had human immunodeficiency virus (HIV) infection and 12 of whom had AIDS. RESULTS: Pulmonary aspergillosis was detected a median of 25 months after the diagnosis of AIDS, usually following corticosteroid use, neutropenia, pneumonia due to other pathogens, marijuana smoking, or the use of broad-spectrum antibiotics. Two major patterns of disease were observed: invasive aspergillosis (in 10 patients) and obstructing bronchial aspergillosis (in 3). Cough and fever, the most common symptoms, tended to be insidious in onset in patients with invasive disease (median duration, 1.3 months before diagnosis). Breathlessness, cough, and chest pain predominated in the three patients with obstructing bronchial aspergillosis, who coughed up fungal casts. Radiologic patterns included upper-lobe cavitary disease (sometimes mistaken for tuberculosis), nodules, pleural-based lesions, and diffuse infiltrates, usually of the lower lobe. Transbronchial biopsies were usually negative, but positive cultures were obtained from bronchoalveolar-lavage fluid or percutaneous aspirates. Dissemination to other organs occurred in at least two patients, and direct invasion of extrapulmonary sites was seen in two others. The results of treatment with amphotericin B, itraconazole, or both were variable. Ten of the patients died a median of 3 months after the diagnosis (range, 0 to 12 months). CONCLUSIONS: Pulmonary aspergillosis is a possible late complication of AIDS; if diagnosed early, it may be treated successfully.
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Citations
Cites
Antifungal and Surgical Treatment of Invasive Aspergillosis: Review of 2,121 Published Cases
Denning, D. W., & Stevens, D. A. (1990) · Clinical Infectious Diseases · doi:10.1093/clinids/12.6.1147 · Cited by 899
Self-citationMurray, J. F., Felton, C. P., Garay, S. M., Gottlieb, M. S., Hopewell, P. C., Stover, D. E., & Teirstein, A. S. (1984) · New England Journal of Medicine · doi:10.1056/nejm198406213102529 · Cited by 687
Neuropathology of Acquired Immunodeficiency Syndrome (AIDS)
Petito, C. K., CHO, E.-S., Lemann, W., NAVIA, B. A., & Price, R. W. (1986) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-198611000-00003 · Cited by 461
Treatment of invasive aspergillosis with itraconazole
Denning, D. W., Tucker, R. M., Hansen, L. H., & Stevens, D. A. (1989) · The American Journal of Medicine · doi:10.1016/0002-9343(89)90475-0 · Cited by 364
Self-citationFungal infection in chronic granulomatous disease
Cohen, M. S., Isturiz, R. E., Malech, H. L., Root, R. K., Wilfert, C. M., Gutman, L., & Buckley, R. H. (1981) · The American Journal of Medicine · doi:10.1016/0002-9343(81)90259-x · Cited by 352
Rand, K. H., Pollard, R. B., & Merigan, T. C. (1978) · New England Journal of Medicine · doi:10.1056/nejm197804272981705 · Cited by 233
Itraconazole Therapy for Cryptococcal Meningitis and Cryptococcosis
Denning, D. W. (1989) · Archives of Internal Medicine · doi:10.1001/archinte.149.10.2301 · Cited by 215
Self-citationDisposition of ketoconazole, an oral antifungal, in humans
Brass, C., Galgiani, J. N., Blaschke, T. F., Defelice, R., O'Reilly, R. A., & Stevens, D. A. (1982) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.21.1.151 · Cited by 210
Self-citationVALUE OF NECROPSY IN ACQUIRED IMMUNODEFICIENCY SYNDROME
Wilkes, M., Felix, J., Fortin, A., Godwin, T., & Thompson, W. (1988) · The Lancet · doi:10.1016/s0140-6736(88)90014-1 · Cited by 158
Fatal aspergillosis associated with smoking contaminated marijuana, in a marrow transplant recipient
Hamadeh, R., Ardehali, A., Locksley, R. M., & York, M. K. (1988) · Chest · doi:10.1378/chest.94.2.432 · Cited by 151
Cited by
Aspergillus fumigatus and Aspergillosis
Latgé, J.-P. (1999) · Clinical Microbiology Reviews · doi:10.1128/cmr.12.2.310 · Cited by 2,307
Ullmann, A. J., Aguado, J. M., Arikan-Akdagli, S., Denning, D. W., Groll, A. H., Lagrou, K., Lass-Flörl, C., Lewis, R. E., Munoz, P., Verweij, P. E., et al. (2018) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2018.01.002 · Cited by 1,556
Self-citationCryptococcosis in the era of AIDS--100 years after the discovery of Cryptococcus neoformans
Mitchell, T. G., & Perfect, J. R. (1995) · Clinical Microbiology Reviews · doi:10.1128/cmr.8.4.515 · Cited by 1,213
Chronic pulmonary aspergillosis: rationale and clinical guidelines for diagnosis and management
Denning, D. W., Cadranel, J., Beigelman-Aubry, C., Ader, F., Chakrabarti, A., Blot, S., Ullmann, A. J., Dimopoulos, G., & Lange, C. (2016) · European Respiratory Journal · doi:10.1183/13993003.00583-2015 · Cited by 1,030
Self-citationItraconazole resistance in Aspergillus fumigatus
Denning, D. W., Venkateswarlu, K., Oakley, K. L., Anderson, M. J., Manning, N. J., Stevens, D. A., Warnock, D. W., & Kelly, S. L. (1997) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.41.6.1364 · Cited by 508
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Metadata
- Authors
- Denning, D. W., Follansbee, S. E., Scolaro, M., Norris, S., Edelstein, H., & Stevens, D. A.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1991-03-07
- Volume
- 324
- Issue
- 10
- Pages
- 654-662
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2317943467
- Cited by
- 503
- References
- 15
- FWCI
- 28.51
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Denning, D. W., Follansbee, S. E., Scolaro, M., Norris, S., Edelstein, H., & Stevens, D. A. (1991). Pulmonary Aspergillosis in the Acquired Immunodeficiency Syndrome. New England Journal of Medicine. https://doi.org/10.1056/nejm199103073241003
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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