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Cited by 2,307Antifungal resistance and susceptibilityFungal and yeast genetics researchFungal Infections and Studies

Aspergillus fumigatus and Aspergillosis

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Latgé, Jean-Paul·1999·Clinical Microbiology Reviews
DOI 10.1128/cmr.12.2.310PMC PMC88920
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Abstract

Aspergillus fumigatus is one of the most ubiquitous of the airborne saprophytic fungi. Humans and animals constantly inhale numerous conidia of this fungus. The conidia are normally eliminated in the immunocompetent host by innate immune mechanisms, and aspergilloma and allergic bronchopulmonary aspergillosis, uncommon clinical syndromes, are the only infections observed in such hosts. Thus, A. fumigatus was considered for years to be a weak pathogen. With increases in the number of immunosuppressed patients, however, there has been a dramatic increase in severe and usually fatal invasive aspergillosis, now the most common mold infection worldwide. In this review, the focus is on the biology of A. fumigatus and the diseases it causes. Included are discussions of (i) genomic and molecular characterization of the organism, (ii) clinical and laboratory methods available for the diagnosis of aspergillosis in immunocompetent and immunocompromised hosts, (iii) identification of host and fungal factors that play a role in the establishment of the fungus in vivo, and (iv) problems associated with antifungal therapy.

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Authors
Latgé, J.-P.
Affiliations
<!--label omitted: 1-->Laboratoire des Aspergillus, Institut Pasteur, 75015 Paris, France
Venue
Clinical Microbiology Reviews
Publisher
American Society for Microbiology
Published
1999-04
Volume
12
Issue
2
Pages
310-350
ISSN
  • 0893-8512 (ISSN-L)
  • 1098-6618
DOI
10.1128/cmr.12.2.310
PMC
PMC88920
OpenAlex
W2153911335
Cited by
2,307
References
742
Citations by year
2026: 33 · 2025: 54 · 2024: 73 · 2023: 58 · 2022: 61 · 2021: 93 · 2020: 97 · 2019: 95 · 2018: 84 · 2017: 99 · 2016: 96 · 2015: 90 · 2014: 125 · 2013: 115 · 2012: 105
FWCI
11.42
Type
journal article
Language
en
Open access
Licence
journals.asm.org/non-commercial-tdm-license (tdm)
Locations
  • Clinical Microbiology Reviews (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
  • Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
Keywords
Aspergillus fumigatus, aspergillosis, invasive aspergillosis, allergic bronchopulmonary aspergillosis, immunosuppression, fungal conidia, innate immunity, fungal genomics, molecular characterization, host-pathogen interaction, antifungal therapy
MeSH terms
Animals, Antigens, Fungal, Aspergillosis, Aspergillus fumigatus, Disease Models, Animal, Humans, Serologic Tests, Virulence

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