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Clozapine: A Novel Antipsychotic Agent
Abstract
THE introduction of chlorpromazine in 1952 marked a turning point in the treatment of schizophrenia and other psychotic disorders.1 Until then, the treatment of these illnesses had met with little success, and many patients with psychosis were held in largely custodial institutions for indefinite periods. Antipsychotic drugs brought new hope that morbidity and dysfunction in such patients could be ameliorated. In the past four decades, however, the limitations of the available agents have become clear: they fail to have appreciable benefit in perhaps 20 percent of patients with schizophrenia,1 2 3 and they have characteristic, sometimes severe and intolerable neurologic side effects. . . .
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Citations
Cited by
Olanzapine versus placebo in the treatment of acute mania
Tohen, M., Sanger, T. M., McElroy, S. L., Tollefson, G. D., Chengappa, K. N. R., Daniel, D. G., Petty, F., Centorrino, F., Wang, R., Grundy, S. L., et al. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.5.702 · Cited by 585
Baldessarini, R. J. (2013) · doi:10.1007/978-1-4614-3710-9 · Cited by 365
Self-citationMechanisms of action of atypical antipsychotic drugs: a critical analysis
Kinon, B. J., & Lieberman, J. A. (1996) · Psychopharmacology · doi:10.1007/bf02245602 · Cited by 317
Clinical risk following abrupt and gradual withdrawal of maintenance neuroleptic treatment
Viguera, A. C. (1997) · Archives of General Psychiatry · doi:10.1001/archpsyc.1997.01830130055011 · Cited by 246
Atypical Antipsychotics Part I: Pharmacology, Pharmacokinetics, and Efficacy
Markowitz, J. S., Brown, C. S., & Moore, T. R. (1999) · Annals of Pharmacotherapy · doi:10.1345/aph.17215 · Cited by 208
Metadata
- Authors
- Oates, J. A., Wood, A. J. J., Baldessarini, R. J., & Frankenburg, F. R.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1991-03-14
- Volume
- 324
- Issue
- 11
- Pages
- 746-754
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2045581755
- Cited by
- 687
- References
- 0
- FWCI
- 39.06
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Clozapine: A Novel Antipsychotic Agent. https://app.cochat.ai/papers/10.1056/nejm199103143241107
- The paper
- Oates, J. A., Wood, A. J. J., Baldessarini, R. J., & Frankenburg, F. R. (1991). Clozapine: A Novel Antipsychotic Agent. New England Journal of Medicine. https://doi.org/10.1056/nejm199103143241107
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
