The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Response to Interferon Alfa-2b in a Patient with Systemic Mastocytosis
Abstract
IN systemic mastocytosis, an abnormal proliferation of mast cells infiltrates the skin, bone marrow, spleen, liver, and lymph nodes.1 2 3 The release of mast-cell mediators such as histamine causes systemic attacks, with flushing, itching, headache, gastrointestinal symptoms, and even vascular collapse with syncope.1 Although the life expectancy of most patients is good, some have a malignant form of the disease, aggressive systemic mast-cell disease, in which there is marked infiltration of organs by mast cells and a rapidly progressive downhill course.1 The presence of leukemic circulating mast cells indicates a particularly grave prognosis.1 , 4 , 5 So far, there is no effective treatment for . . .
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Citations
Cites
Improved Diagnosis of Mastocytosis by Measurement of Urinary Hist Amine Metabolites
Keyzer, J. J., de Monchy, J. G. R., van Doormaal, J. J., & van Voorst Vader, P. C. (1983) · New England Journal of Medicine · doi:10.1056/nejm198312293092603 · Cited by 179
Cited by
Mastocytosis: 2016 updated WHO classification and novel emerging treatment concepts
Valent, P., Akin, C., & Metcalfe, D. D. (2017) · Blood · doi:10.1182/blood-2016-09-731893 · Cited by 592
Metcalfe, D. D. (2008) · Blood · doi:10.1182/blood-2007-11-078097 · Cited by 536
Systemic mastocytosis in adults: 2023 update on diagnosis, risk stratification and management
Pardanani, A. (2023) · American Journal of Hematology · doi:10.1002/ajh.26962 · Cited by 132
Weiler, C. R., Austen, K. F., Akin, C., Barkoff, M. S., Bernstein, J. A., Bonadonna, P., Butterfield, J. H., Carter, M., Fox, C. C., Maitland, A., et al. (2019) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2019.08.023 · Cited by 123
Gülen, T., Akin, C., Bonadonna, P., Siebenhaar, F., Broesby-Olsen, S., Brockow, K., Niedoszytko, M., Nedoszytko, B., Oude Elberink, H. N. G., Butterfield, J. H., et al. (2021) · The Journal of Allergy and Clinical Immunology: In Practice · doi:10.1016/j.jaip.2021.06.011 · Cited by 83
“Agents targeting growth and activation of neoplastic MCs, such as KIT-targeting kinase blockers, are often recommended in advanced SM.(89-92) For instance, midostaurin is a broadly acting signal transduction inhibitor that recognizes kinase targets (such as SYK) downstream of the IgE receptor.”
Background
Metadata
- Authors
- Kluin-Nelemans, H. C., Jansen, J. H., Breukelman, H., Wolthers, B. G., Kluin, P. M., Kroon, H. M., & Willemze, R.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1992-02-27
- Volume
- 326
- Issue
- 9
- Pages
- 619-623
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2330995554
- Cited by
- 232
- References
- 1
- FWCI
- 4.03
- Type
- journal article
- Language
- en
- Open access
- closed
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Cite CoChat for the checks on this page, and the paper for its own findings.
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- CoChat. (2026). Citation check: Response to Interferon Alfa-2b in a Patient with Systemic Mastocytosis. https://app.cochat.ai/papers/10.1056/nejm199202273260907
- The paper
- Kluin-Nelemans, H. C., Jansen, J. H., Breukelman, H., Wolthers, B. G., Kluin, P. M., Kroon, H. M., & Willemze, R. (1992). Response to Interferon Alfa-2b in a Patient with Systemic Mastocytosis. New England Journal of Medicine. https://doi.org/10.1056/nejm199202273260907
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
